Similar articles for PMID: 19803472

Year	Number of Results
1993	1
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2005	14
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2008	4
2009	5
2010	5
2011	4
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2013	10
2014	8
2015	10
2016	6
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2018	5
2019	3
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1

Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: implications for pulmonary and hepatic toxicities.

Li X, Kamenecka TM, Cameron MD. Li X, et al. Chem Res Toxicol. 2009 Oct;22(10):1736-42. doi: 10.1021/tx900256y. Chem Res Toxicol. 2009. PMID: 19803472

2

Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile.

Li X, Kamenecka TM, Cameron MD. Li X, et al. Drug Metab Dispos. 2010 Jul;38(7):1238-45. doi: 10.1124/dmd.109.030361. Epub 2010 Apr 9. Drug Metab Dispos. 2010. PMID: 20382753 Free PMC article.

3

Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.

Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, Zhang Y, Krishnamurthy P, Li F. Liu X, et al. Biochem Pharmacol. 2015 Sep 1;97(1):111-21. doi: 10.1016/j.bcp.2015.07.010. Epub 2015 Jul 23. Biochem Pharmacol. 2015. PMID: 26212543

4

Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.

Alfieri RR, Galetti M, Tramonti S, Andreoli R, Mozzoni P, Cavazzoni A, Bonelli M, Fumarola C, La Monica S, Galvani E, De Palma G, Mutti A, Mor M, Tiseo M, Mari E, Ardizzoni A, Petronini PG. Alfieri RR, et al. Mol Cancer. 2011 Nov 23;10:143. doi: 10.1186/1476-4598-10-143. Mol Cancer. 2011. PMID: 22111840 Free PMC article.

5

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

Stiborová M, Arlt VM, Henderson CJ, Wolf CR, Kotrbová V, Moserová M, Hudecek J, Phillips DH, Frei E. Stiborová M, et al. Toxicol Appl Pharmacol. 2008 Feb 1;226(3):318-27. doi: 10.1016/j.taap.2007.09.017. Epub 2007 Sep 26. Toxicol Appl Pharmacol. 2008. PMID: 17976674

6

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.

Chen Q, Ngui JS, Doss GA, Wang RW, Cai X, DiNinno FP, Blizzard TA, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Chem Res Toxicol. 2002 Jul;15(7):907-14. doi: 10.1021/tx0200109. Chem Res Toxicol. 2002. PMID: 12119000

7

Metabolite characterization of anti-cancer agent gefitinib in human hepatocytes.

Surve P, Ravindran S, Acharjee A, Rastogi H, Basu S, Honrao P. Surve P, et al. Drug Metab Lett. 2014 Jul;7(2):126-36. doi: 10.2174/1872312808666140317154110. Drug Metab Lett. 2014. PMID: 24628403

8

Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.

Stiborová M, Poljaková J, Martínková E, Ulrichová J, Simánek V, Dvořák Z, Frei E. Stiborová M, et al. Toxicology. 2012 Dec 16;302(2-3):233-41. doi: 10.1016/j.tox.2012.08.004. Epub 2012 Aug 16. Toxicology. 2012. PMID: 22917556

9

3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.

Arlt VM, Hewer A, Sorg BL, Schmeiser HH, Phillips DH, Stiborova M. Arlt VM, et al. Chem Res Toxicol. 2004 Aug;17(8):1092-101. doi: 10.1021/tx049912v. Chem Res Toxicol. 2004. PMID: 15310241

10

Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

Arlt VM, Levová K, Bárta F, Shi Z, Evans JD, Frei E, Schmeiser HH, Nebert DW, Phillips DH, Stiborová M. Arlt VM, et al. Chem Res Toxicol. 2011 Oct 17;24(10):1710-9. doi: 10.1021/tx200259y. Epub 2011 Sep 29. Chem Res Toxicol. 2011. PMID: 21932800

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