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27197573,32539815,28166825,31751675,25082877,30076280,23535063,28939454,23672350,23528260,29096332,23053179,28395444,33740924,33474629,32101640,31173897,24616160,15168592,31364309,28219218,18801058,23542687,24954546,28159598,33524443,26223865,25804769,26635039,25449688,26994850,25314777,35185899,32311890,25260824,35531760,25860287,30181104,25758097,28939453,28067876,28673850,19463768,35045670,31554635,32023749,24402164,20412098,24933658,10814988,22975772,28646534,31257540,32588434,27058617,30612399,24338939,22875911,34547870,28063196,26537612,36845681,31688618,26589909,25912052,23067220,35070977,27673579,30511683,26138637,26221900,30251205,26970379,28846953,26211985,29946906,34025637,26980726,22281301,24035334,29872884,33160932,31899799,25130809,27733089,14645432,28089879,25612891,33529373,30100330,25932436,19752335,30159599,30773106,31004601,28279035,33477584,25480496,19167615,26715369,23294252,16254134,27471865,22291086,26519872,24702162,27239735,32397017,30268640,31162830,22551655,30612398,22278196,34979982,19458628,24752047,24149098,19891700,22564995,26010177,23567175,30383631,33208771,33795645,28058493,24973361,12764380,29753838,23837640,33049225,16620548,23547840,28004352,9489633,33812416,27373985,33830030,27798920,28189799,21756806,28322996,25139215,27302479,33882316,14704656,25890432,30801534,33987857,19099637,23826993,25111512,21606963,34625784,18606980,19549401,20137139,36824620,27770540,26228220,33655416,33840380,27629395,26573082,26551637,29696374,24631740,35061336,16277833,32741803,34232303,27650511,33191833,35390479,27544285,30285885,26462631,31860405,36757706,19176061,25840336,28056203,30929382,29698793,27492792,33150388,27478011,26059733,34120331,10648391,30616990,31227357,34873148,30442503,18553224,24510069,31707119,31111633,33712867,32122281,29384595,36817493,28163010,32804016,28954346,29264741,28370339,27225156,29397851,28494506,31856435,30507323,29493383,15291357,29978286,31395600,32888885,18215779,30523055,30758645,19126873,29051022,36881031,35377134,34992253,23646898,33648437,28114959,29124313,34183780,33500364,30190321,27342486,27178373,32090321,27561414,28219225,19424569,29515250,31839036,23998570,27506214,31725954,29166742,26084204,24763021,10673520,33174792,22172252,31756777,37104677,31122828,30122014,30607578,7577620,24374719,32109757,27139612,34059800,33386742,28736882,33108244,27252013,32519744,21942328,22575183,37024571,29472719,30935386,29785446,29959436,26668349,34176091,19369623,36251406,28387928,31306053,25278455,21937700,35605254,31034759,30997674,34272486,25204372,29684564,32019476,28221862,34871539,34551474,25631772,31775478,35264498,32353911,27881874,34650294,25026287,30177138,23115274,29025598,27742476,31132205,27890261,25778880,22145956,22198310,27391574,19776535,21054152,9844919,36038660,29747291,27502072,27033758,32757686,17666750,27643573,29932212,32577842,32020596,35924583,27042849,26531831,33382538,27111858,17901040,26054017,32011516,33255417,29933069,17350472,23863898,33279940,30637949,28961307,29151502,31422708,25238704,36544347,32810221,30626126,34088902,30144151,34297437,32862286,31124175,34118468,35187981,23672346,34588432,34289154,27621140,20046081,30954622,33868266,28840298,21380778,23673857,32008291,19629629,32871585,29286103,28978830,28954349,27736291,15968311,33138674,31540855,29519618,26422713,27540139,26520650,9028159,33327316,31028135,31211880,17487738,28628276,28655096,35231903,26224397,26197471,26314268,16468240,28384176,28679992,22580999,25287662,31040112,28933735,21504297,30273780,23321257,27843138,9648562,27930388,25110071,30457973,24897507,28641652,27014980,32873914,28299658,22982533,29568097,34248126,31768015,30734356,32115572,18297529,20849384,26473413,30900388,32829005,32323913,18671757,31004014,26390722,29283907,30466757,28883285,25822226,32955825,16291592,31638252,32243655,35286378,33067946,29721072,30959925,14617001,35673748,19734423,31916883,27512765,29408852,32760007,30117318,26358057,30677244,27667292,31974434,20634493,28133783,23082952,36529759,12406915,33407700,21076613,21106987,24652988,25052308,24673627,16384925,30068244,25380682,25202702,30706625,31167998,32705716,20063133,30969080,30610028,29704019,31238330,31901918,35119651,35150150,30569130,28455005,22535659,33773407,27244369,30612401,31755224,31235963,33316797,28949951,33469688,36542104,31935293,27974109,29427188,30950667,28762080,33636567,31155409,33782817,31919123,28717086,30024969,31176789,30249531,28427460,31896684,26660427,32027287,29500710,25617314,29950211,31247675,35184217,35933982,37088803,27540133,27431069,34020318,37096505,27342485,34731121,23095794,33257285,18253706,22015946,35841458,33249666,31253168,31794134,19171881,30741367,28830889,30943060,26514528,34120595,34739701,26040504,31209266,36286725,18785507,30506133,36709108,30396184,36709175,18591546,30267597,24867777,36404533,36031670,15223632,31667544,19901261,36151367,33351107,24441146,23616221,29415939,28940816,33564120,31892587,23979985,33324478,28280089,31027331,26361793,11999359,31503019,23102703,26992216,3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Low WT1 transcript levels at diagnosis predicted poor outcomes of acute myeloid leukemia patients with t(8;21) who received chemotherapy or allogeneic hematopoietic stem cell transplantation.

Qin YZ, Wang Y, Zhu HH, Gale RP, Zhang MJ, Jiang Q, Jiang H, Xu LP, Chen H, Zhang XH, Liu YR, Lai YY, Jiang B, Liu KY, Huang XJ. Qin YZ, et al. Chin J Cancer. 2016 May 19;35:46. doi: 10.1186/s40880-016-0110-6. Chin J Cancer. 2016. PMID: 27197573 Free PMC article.

Allogeneic hematopoietic stem cell transplantation can improve the prognosis of high-risk pediatric t(8;21) acute myeloid leukemia in first remission based on MRD-guided treatment.

Hu GH, Cheng YF, Lu AD, Wang Y, Zuo YX, Yan CH, Wu J, Sun YQ, Suo P, Chen YH, Chen H, Jia YP, Liu KY, Han W, Xu LP, Zhang LP, Huang XJ. Hu GH, et al. BMC Cancer. 2020 Jun 15;20(1):553. doi: 10.1186/s12885-020-07043-5. BMC Cancer. 2020. PMID: 32539815 Free PMC article. Clinical Trial.

The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia.

Qin YZ, Wang Y, Xu LP, Zhang XH, Chen H, Han W, Chen YH, Wang FR, Wang JZ, Chen Y, Mo XD, Zhao XS, Chang YJ, Liu KY, Huang XJ. Qin YZ, et al. J Hematol Oncol. 2017 Feb 6;10(1):44. doi: 10.1186/s13045-017-0414-2. J Hematol Oncol. 2017. PMID: 28166825 Free PMC article.

Subgroup Analysis Can Optimize the Relapse-Prediction Cutoff Value for WT1 Expression After Allogeneic Hematologic Stem Cell Transplantation in Acute Myeloid Leukemia.

Qin YZ, Wang Y, Xu LP, Zhang XH, Zhao XS, Liu KY, Huang XJ. Qin YZ, et al. J Mol Diagn. 2020 Feb;22(2):188-195. doi: 10.1016/j.jmoldx.2019.10.003. Epub 2019 Nov 18. J Mol Diagn. 2020. PMID: 31751675 Free article.

In adults with t(8;21)AML, posttransplant RUNX1/RUNX1T1-based MRD monitoring, rather than c-KIT mutations, allows further risk stratification.

Wang Y, Wu DP, Liu QF, Qin YZ, Wang JB, Xu LP, Liu YR, Zhu HH, Chen J, Dai M, Huang XJ. Wang Y, et al. Blood. 2014 Sep 18;124(12):1880-6. doi: 10.1182/blood-2014-03-563403. Blood. 2014. PMID: 25082877 Free article.

Interferon-α Is Effective for Treatment of Minimal Residual Disease in Patients with t(8;21) Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Registry Study.

Mo XD, Wang Y, Zhang XH, Xu LP, Yan CH, Chen H, Chen YH, Qin YZ, Liu KY, Huang XJ. Mo XD, et al. Oncologist. 2018 Nov;23(11):1349-1357. doi: 10.1634/theoncologist.2017-0692. Epub 2018 Aug 3. Oncologist. 2018. PMID: 30076280 Free PMC article.

MRD-directed risk stratification treatment may improve outcomes of t(8;21) AML in the first complete remission: results from the AML05 multicenter trial.

Zhu HH, Zhang XH, Qin YZ, Liu DH, Jiang H, Chen H, Jiang Q, Xu LP, Lu J, Han W, Bao L, Wang Y, Chen YH, Wang JZ, Wang FR, Lai YY, Chai JY, Wang LR, Liu YR, Liu KY, Jiang B, Huang XJ. Zhu HH, et al. Blood. 2013 May 16;121(20):4056-62. doi: 10.1182/blood-2012-11-468348. Epub 2013 Mar 27. Blood. 2013. PMID: 23535063 Free article. Clinical Trial.

Outcome and Minimal Residual Disease Monitoring in Patients with t(16;21) Acute Myelogenous Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

Qin YZ, Chen Y, Xu LP, Wang Y, Zhang XH, Chen H, Zhao XS, Liu KY, Huang XJ. Qin YZ, et al. Biol Blood Marrow Transplant. 2018 Jan;24(1):163-168. doi: 10.1016/j.bbmt.2017.09.002. Epub 2017 Sep 20. Biol Blood Marrow Transplant. 2018. PMID: 28939454 Free article.

BAALC and WT1 expressions from diagnosis to hematopoietic stem cell transplantation: consecutive monitoring in adult patients with core-binding-factor-positive AML.

Yoon JH, Kim HJ, Shin SH, Yahng SA, Lee SE, Cho BS, Eom KS, Kim YJ, Lee S, Min CK, Cho SG, Kim DW, Lee JW, Min WS, Park CW, Lim JH. Yoon JH, et al. Eur J Haematol. 2013 Aug;91(2):112-21. doi: 10.1111/ejh.12142. Epub 2013 Jun 28. Eur J Haematol. 2013. PMID: 23672350

Effects of c-KIT mutations on expression of the RUNX1/RUNX1T1 fusion transcript in t(8;21)-positive acute myeloid leukemia patients.

Park SH, Chi HS, Cho YU, Jang S, Park CJ. Park SH, et al. Leuk Res. 2013 Jul;37(7):784-9. doi: 10.1016/j.leukres.2013.02.010. Epub 2013 Mar 22. Leuk Res. 2013. PMID: 23528260

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