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Year Number of Results
2000 6
2001 1
2002 2
2003 3
2004 4
2005 2
2006 2
2007 2
2008 2
2009 1
2012 1
2014 1
2015 1
2017 1
2020 1
2024 0

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28 results

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Page 1
Mechanism for p38alpha-mediated experimental autoimmune encephalomyelitis.
Namiki K, Matsunaga H, Yoshioka K, Tanaka K, Murata K, Ishida J, Sakairi A, Kim J, Tokuhara N, Shibakawa N, Shimizu M, Wada Y, Tokunaga Y, Shigetomi M, Hagihara M, Kimura S, Sudo T, Fukamizu A, Kasuya Y. Namiki K, et al. Among authors: sudo t. J Biol Chem. 2012 Jul 13;287(29):24228-38. doi: 10.1074/jbc.M111.338541. Epub 2012 May 25. J Biol Chem. 2012. PMID: 22637476 Free PMC article.
In this study, we analyzed the roles of p38alpha in multiple sclerosis, using an animal model, experimental autoimmune encephalomyelitis (EAE). p38alpha(+/-) mice (p38alpha(-/-) showed embryonic lethality) showed less severe neurological signs than WT mice. A …
In this study, we analyzed the roles of p38alpha in multiple sclerosis, using an animal model, experimental autoimmune encephalomyeli …
Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.
Otsu K, Yamashita N, Nishida K, Hirotani S, Yamaguchi O, Watanabe T, Hikoso S, Higuchi Y, Matsumura Y, Maruyama M, Sudo T, Osada H, Hori M. Otsu K, et al. Among authors: sudo t. Biochem Biophys Res Commun. 2003 Feb 28;302(1):56-60. doi: 10.1016/s0006-291x(03)00096-2. Biochem Biophys Res Commun. 2003. PMID: 12593847
The p38alpha protein level in the p38alpha(+/-) heart was 50+/-8.7% compared with that in the p38alpha(+/+) heart. Upon reperfusion following ischemia for 25min, p38alpha activity was transiently increased. The maximum level of p38 activity in …
The p38alpha protein level in the p38alpha(+/-) heart was 50+/-8.7% compared with that in the p38alpha(+/+) heart. Upon …
Genetic and Pharmacological Inhibition of p38alpha Improves Locomotor Recovery after Spinal Cord Injury.
Umezawa H, Naito Y, Tanaka K, Yoshioka K, Suzuki K, Sudo T, Hagihara M, Hatano M, Tatsumi K, Kasuya Y. Umezawa H, et al. Among authors: sudo t. Front Pharmacol. 2017 Feb 17;8:72. doi: 10.3389/fphar.2017.00072. eCollection 2017. Front Pharmacol. 2017. PMID: 28261102 Free PMC article.
In this study, we investigated the pathophysiological roles of p38alpha in spinal cord injury (SCI), using a mouse model. Lateral hemisection at T9 of the SC was performed in wild type (WT) and p38alpha(+/-) mice (p38alpha(-/-) showed embryonic lethality). …
In this study, we investigated the pathophysiological roles of p38alpha in spinal cord injury (SCI), using a mouse model. Lateral hem …
Involvement of p38alpha in kainate-induced seizure and neuronal cell damage.
Namiki K, Nakamura A, Furuya M, Mizuhashi S, Matsuo Y, Tokuhara N, Sudo T, Hama H, Kuwaki T, Yano S, Kimura S, Kasuya Y. Namiki K, et al. Among authors: sudo t. J Recept Signal Transduct Res. 2007;27(2-3):99-111. doi: 10.1080/10799890701357855. J Recept Signal Transduct Res. 2007. PMID: 17613723
We investigated how p38alpha mitogen-activated protein kinase (p38) is related to kainate-induced epilepsy and neuronal damages, by using the mice with a single copy disruption of the p38 alpha gene (p38alpha(+/-)). ...These results suggest that p38 …
We investigated how p38alpha mitogen-activated protein kinase (p38) is related to kainate-induced epilepsy and neuronal damage …
p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression.
Sudo T, Kawai K, Matsuzaki H, Osada H. Sudo T, et al. Biochem Biophys Res Commun. 2005 Nov 18;337(2):415-21. doi: 10.1016/j.bbrc.2005.09.063. Epub 2005 Sep 20. Biochem Biophys Res Commun. 2005. PMID: 16198317
Among p38 families, p38alpha is a widely characterized isoform and the biological phenomena are explained by its kinase activity regulating functions of its downstream substrates. ...Together, we have established cell lines that can be used in analyzing the function …
Among p38 families, p38alpha is a widely characterized isoform and the biological phenomena are explained by its kinase activi …
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.
Asada S, Daitoku H, Matsuzaki H, Saito T, Sudo T, Mukai H, Iwashita S, Kako K, Kishi T, Kasuya Y, Fukamizu A. Asada S, et al. Among authors: sudo t. Cell Signal. 2007 Mar;19(3):519-27. doi: 10.1016/j.cellsig.2006.08.015. Epub 2006 Aug 30. Cell Signal. 2007. PMID: 17113751
In vitro kinase assay showed that Foxo1 was phosphorylated by extracellular signal-regulated kinase (Erk) and p38 MAPK (p38) but not by c-jun NH2-terminal kinase (JNK). In NIH3T3 cells, epidermal growth factor or anisomycin increased phosphorylation of exogenous Fox …
In vitro kinase assay showed that Foxo1 was phosphorylated by extracellular signal-regulated kinase (Erk) and p38 MAPK (p38) b …
Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1.
Kawai K, Saito A, Sudo T, Osada H. Kawai K, et al. Among authors: sudo t. J Biochem. 2008 Jun;143(6):765-72. doi: 10.1093/jb/mvn027. Epub 2008 Feb 22. J Biochem. 2008. PMID: 18296712
We have previously shown that p62/SQSTM1 binds to p38. In this study, we identified two association domains of p62 to p38 by conducting co-immunoprecipitation experiments. One domain comprises the amino acids 173-182, named N-terminal p38 interaction (NPI) do …
We have previously shown that p62/SQSTM1 binds to p38. In this study, we identified two association domains of p62 to p38 by c …
Renal abnormalities in mice caused by insufficiency of p38alpha.
Maruyama M, Yagasaki Y, Sudo T, Osada H. Maruyama M, et al. Among authors: sudo t. J Recept Signal Transduct Res. 2003;23(2-3):173-83. doi: 10.1081/rrs-120025197. J Recept Signal Transduct Res. 2003. PMID: 14626445
Although there are many aspects of the molecular events via the p38 pathway, its contribution to renal physiology and pathophysiology remains unclear. To elucidate the physiological relevance of p38 in renal function, we performed histochemical and biochemical chara …
Although there are many aspects of the molecular events via the p38 pathway, its contribution to renal physiology and pathophysiology …
Transcriptomic Evaluation of Pulmonary Fibrosis-Related Genes: Utilization of Transgenic Mice with Modifying p38 Signal in the Lungs.
Matsuda S, Kim JD, Sugiyama F, Matsuo Y, Ishida J, Murata K, Nakamura K, Namiki K, Sudo T, Kuwaki T, Hatano M, Tatsumi K, Fukamizu A, Kasuya Y. Matsuda S, et al. Among authors: sudo t. Int J Mol Sci. 2020 Sep 14;21(18):6746. doi: 10.3390/ijms21186746. Int J Mol Sci. 2020. PMID: 32937976 Free PMC article.
Transcriptome analysis of these lung samples also showed that the enhanced p38 signaling in the lungs was associated with increased transcription of the genes driving the p38 MAPK pathway and differentially expressed genes elicited by BLM, including those related to …
Transcriptome analysis of these lung samples also showed that the enhanced p38 signaling in the lungs was associated with increased t …
p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.
Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y. Amano H, et al. Among authors: sudo t. J Recept Signal Transduct Res. 2014 Aug;34(4):299-306. doi: 10.3109/10799893.2014.896380. Epub 2014 Mar 5. J Recept Signal Transduct Res. 2014. PMID: 24593255
However, the precise mechanism how p38 contributes to the pathogenesis of COPD is still unknown. OBJECTIVE: We attempted to create a new mouse model for COPD by intra-tracheal administration of a mixture of lipopolysaccharide (LPS) and cigarette smoke solution (CSS), and i …
However, the precise mechanism how p38 contributes to the pathogenesis of COPD is still unknown. OBJECTIVE: We attempted to create a …
28 results