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Compartmentalized SARS-CoV-2 replication in upper versus lower respiratory tract after intranasal inoculation or aerosol exposure.
Fischer RJ, Bushmaker T, Williamson BN, Pérez-Pérez L, Feldmann F, Lovaglio J, Scott D, Saturday G, Feldmann H, Munster VJ, de Wit E, van Doremalen N. Fischer RJ, et al. J Infect Dis. 2024 Jan 23:jiae018. doi: 10.1093/infdis/jiae018. Online ahead of print. J Infect Dis. 2024. PMID: 38261786
Intranasal inoculation results in replication in the upper respiratory tract and limited lower respiratory tract involvement, whereas exposure to aerosols results in infection throughout the respiratory trac …
Intranasal inoculation results in replication in the upper respiratory tract and limited lower …
A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys.
Prasad AN, Agans KN, Sivasubramani SK, Geisbert JB, Borisevich V, Mire CE, Lawrence WS, Fenton KA, Geisbert TW. Prasad AN, et al. J Infect Dis. 2020 May 11;221(Suppl 4):S431-S435. doi: 10.1093/infdis/jiz469. J Infect Dis. 2020. PMID: 31665351
Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiVM), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreak …
Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia …
Aerosol exposure to western equine encephalitis virus causes fever and encephalitis in cynomolgus macaques.
Reed DS, Larsen T, Sullivan LJ, Lind CM, Lackemeyer MG, Pratt WD, Parker MD. Reed DS, et al. J Infect Dis. 2005 Oct 1;192(7):1173-82. doi: 10.1086/444397. Epub 2005 Aug 25. J Infect Dis. 2005. PMID: 16136459
Three cynomolgus macaques died; immunohistochemical evidence of viral antigen was present in the brain and central nervous system (CNS). Microscopic analysis also revealed a marked lymphocytic infiltrate in the CNS. ...
Three cynomolgus macaques died; immunohistochemical evidence of viral antigen was present in the brain and central nervous system (CN …
The Use of Large-Particle Aerosol Exposure to Nipah Virus to Mimic Human Neurological Disease Manifestations in the African Green Monkey.
Lee JH, Hammoud DA, Cong Y, Huzella LM, Castro MA, Solomon J, Laux J, Lackemeyer M, Bohannon JK, Rojas O, Byrum R, Adams R, Ragland D, St Claire M, Munster V, Holbrook MR. Lee JH, et al. J Infect Dis. 2020 May 11;221(Suppl 4):S419-S430. doi: 10.1093/infdis/jiz502. J Infect Dis. 2020. PMID: 31687756 Free PMC article.
Nipah virus (NiV) is an emerging virus associated with outbreaks of acute respiratory disease and encephalitis. To develop a neurological model for NiV infection, we exposed 6 adult African green monkeys to a large-particle (approximately 12 mum) aerosol containing NiV (Ma …
Nipah virus (NiV) is an emerging virus associated with outbreaks of acute respiratory disease and encephalitis. To develop a neurolog …