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Genomic complexity of multiple myeloma and its clinical implications.
Manier S, Salem KZ, Park J, Landau DA, Getz G, Ghobrial IM. Manier S, et al. Among authors: ghobrial im. Nat Rev Clin Oncol. 2017 Feb;14(2):100-113. doi: 10.1038/nrclinonc.2016.122. Epub 2016 Aug 17. Nat Rev Clin Oncol. 2017. PMID: 27531699 Review.
Multiple myeloma (MM) is a genetically complex disease that evolves from pre-malignant stages, such as monoclonal gammaopathy of undetermined significance and smouldering multiple myeloma, and progresses to symptomatic MM; this continuum provides a uni …
Multiple myeloma (MM) is a genetically complex disease that evolves from pre-malignant stages, such as monoclonal gammaopathy …
Single-cell profiling of tumour evolution in multiple myeloma - opportunities for precision medicine.
Dutta AK, Alberge JB, Sklavenitis-Pistofidis R, Lightbody ED, Getz G, Ghobrial IM. Dutta AK, et al. Among authors: ghobrial im. Nat Rev Clin Oncol. 2022 Apr;19(4):223-236. doi: 10.1038/s41571-021-00593-y. Epub 2022 Jan 11. Nat Rev Clin Oncol. 2022. PMID: 35017721 Review.
Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by substantial intraclonal genetic heterogeneity. ...Emerging single-cell sequencing technologies present a superlative solution to delineate the complexity of monoclonal gammopathy o …
Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by substantial intraclonal genetic heteroge …
Genomic Aberrations in Multiple Myeloma.
Manier S, Salem K, Glavey SV, Roccaro AM, Ghobrial IM. Manier S, et al. Among authors: ghobrial im. Cancer Treat Res. 2016;169:23-34. doi: 10.1007/978-3-319-40320-5_3. Cancer Treat Res. 2016. PMID: 27696256 Review.
Multiple myeloma (MM) is a genetically complex disease. The past few years have seen an evolution in cancer research with the emergence of next-generation sequencing (NGS), enabling high throughput sequencing of tumors-including whole exome, whole genome, RNA …
Multiple myeloma (MM) is a genetically complex disease. The past few years have seen an evolution in cancer research with the …
Genome instability in multiple myeloma.
Neuse CJ, Lomas OC, Schliemann C, Shen YJ, Manier S, Bustoros M, Ghobrial IM. Neuse CJ, et al. Among authors: ghobrial im. Leukemia. 2020 Nov;34(11):2887-2897. doi: 10.1038/s41375-020-0921-y. Epub 2020 Jul 10. Leukemia. 2020. PMID: 32651540 Review.
Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal proliferation of plasma cells and a heterogenous genomic landscape. ...We evaluate how the tumor microenvironment can contribute to a further increase in chromosomal instabil …
Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal proliferation of plasma cells and a heter …
Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.
Bustoros M, Anand S, Sklavenitis-Pistofidis R, Redd R, Boyle EM, Zhitomirsky B, Dunford AJ, Tai YT, Chavda SJ, Boehner C, Neuse CJ, Rahmat M, Dutta A, Casneuf T, Verona R, Kastritis E, Trippa L, Stewart C, Walker BA, Davies FE, Dimopoulos MA, Bergsagel PL, Yong K, Morgan GJ, Aguet F, Getz G, Ghobrial IM. Bustoros M, et al. Among authors: ghobrial im. Nat Commun. 2022 Jun 15;13(1):3449. doi: 10.1038/s41467-022-30694-w. Nat Commun. 2022. PMID: 35705541 Free PMC article.
Smoldering multiple myeloma (SMM) is a precursor condition of multiple myeloma (MM) with significant heterogeneity in disease progression. ...
Smoldering multiple myeloma (SMM) is a precursor condition of multiple myeloma (MM) with significant heterogenei …
Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression.
Bustoros M, Sklavenitis-Pistofidis R, Park J, Redd R, Zhitomirsky B, Dunford AJ, Salem K, Tai YT, Anand S, Mouhieddine TH, Chavda SJ, Boehner C, Elagina L, Neuse CJ, Cha J, Rahmat M, Taylor-Weiner A, Van Allen E, Kumar S, Kastritis E, Leshchiner I, Morgan EA, Laubach J, Casneuf T, Richardson P, Munshi NC, Anderson KC, Trippa L, Aguet F, Stewart C, Dimopoulos MA, Yong K, Bergsagel PL, Manier S, Getz G, Ghobrial IM. Bustoros M, et al. Among authors: ghobrial im. J Clin Oncol. 2020 Jul 20;38(21):2380-2389. doi: 10.1200/JCO.20.00437. Epub 2020 May 22. J Clin Oncol. 2020. PMID: 32442065 Free PMC article.
PURPOSE: Smoldering multiple myeloma (SMM) is a precursor condition of multiple myeloma (MM) with a 10% annual risk of progression. ...METHODS: We used next-generation sequencing to study 214 patients with SMM. We performed whole-exome sequencin …
PURPOSE: Smoldering multiple myeloma (SMM) is a precursor condition of multiple myeloma (MM) with a 10% annual r …
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma.
Manier S, Park J, Capelletti M, Bustoros M, Freeman SS, Ha G, Rhoades J, Liu CJ, Huynh D, Reed SC, Gydush G, Salem KZ, Rotem D, Freymond C, Yosef A, Perilla-Glen A, Garderet L, Van Allen EM, Kumar S, Love JC, Getz G, Adalsteinsson VA, Ghobrial IM. Manier S, et al. Among authors: ghobrial im. Nat Commun. 2018 Apr 27;9(1):1691. doi: 10.1038/s41467-018-04001-5. Nat Commun. 2018. PMID: 29703982 Free PMC article.
Here, we report the detectability of cfDNA and CTCs in blood samples from 107 and 56 patients with multiple myeloma (MM), respectively. Using ultra-low pass whole-genome sequencing, we find both tumor fractions correlate with disease progression. ...Important …
Here, we report the detectability of cfDNA and CTCs in blood samples from 107 and 56 patients with multiple myeloma (MM), resp …
Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: a review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease.
Agarwal A, Ghobrial IM. Agarwal A, et al. Among authors: ghobrial im. Clin Cancer Res. 2013 Mar 1;19(5):985-94. doi: 10.1158/1078-0432.CCR-12-2922. Epub 2012 Dec 5. Clin Cancer Res. 2013. PMID: 23224402 Free PMC article. Review.
The recent advances in our knowledge about MGUS and smoldering multiple myeloma (SMM) have helped us better understand the pathogenesis of myeloma. It seems that myeloma evolves from a precursor state in almost all cases. We do not completely understan …
The recent advances in our knowledge about MGUS and smoldering multiple myeloma (SMM) have helped us better understand the pat …
MinimuMM-seq: Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma Pathology.
Dutta AK, Alberge JB, Lightbody ED, Boehner CJ, Dunford A, Sklavenitis-Pistofidis R, Mouhieddine TH, Cowan AN, Su NK, Horowitz EM, Barr H, Hevenor L, Beckwith JB, Perry J, Cao A, Lin Z, Kuhr FK, Mastro RGD, Nadeem O, Greipp PT, Stewart C, Auclair D, Getz G, Ghobrial IM. Dutta AK, et al. Among authors: ghobrial im. Cancer Discov. 2023 Feb 6;13(2):348-363. doi: 10.1158/2159-8290.CD-22-0482. Cancer Discov. 2023. PMID: 36477267
Multiple myeloma (MM) develops from well-defined precursor stages; however, invasive bone marrow (BM) biopsy limits screening and monitoring strategies for patients. We enumerated circulating tumor cells (CTC) from 261 patients (84 monoclonal gammopathy of undetermi …
Multiple myeloma (MM) develops from well-defined precursor stages; however, invasive bone marrow (BM) biopsy limits screening …
Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma.
Kazandjian D, Diamond B, Papadimitriou M, Hill E, Sklavenitis-Pistofidis R, Ziccheddu B, Blaney P, Chojnacka M, Durante M, Maclachlan K, Young R, Usmani S, Davies F, Getz G, Ghobrial I, Korde N, Morgan G, Maura F, Landgren O. Kazandjian D, et al. Among authors: ghobrial i. Clin Cancer Res. 2024 Apr 23. doi: 10.1158/1078-0432.CCR-24-0210. Online ahead of print. Clin Cancer Res. 2024. PMID: 38652812
PURPOSE: Early intervention for High-Risk Smoldering Multiple Myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to treatment of less complex, susceptible disease or inaccuracy in clinical definition of cases entered …
PURPOSE: Early intervention for High-Risk Smoldering Multiple Myeloma (HR-SMM) achieves deep and prolonged responses. It is un …
22 results