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Increasing Racial and Ethnic Diversity in Cancer Clinical Trials: An American Society of Clinical Oncology and Association of Community Cancer Centers Joint Research Statement.
Oyer RA, Hurley P, Boehmer L, Bruinooge SS, Levit K, Barrett N, Benson A, Bernick LA, Byatt L, Charlot M, Crews J, DeLeon K, Fashoyin-Aje L, Garrett-Mayer E, Gralow JR, Green S, Guerra CE, Hamroun L, Hardy CM, Hempstead B, Jeames S, Mann M, Matin K, McCaskill-Stevens W, Merrill J, Nowakowski GS, Patel MI, Pressman A, Ramirez AG, Segura J, Segarra-Vasquez B, Hanley Williams J, Williams JE Jr, Winkfield KM, Yang ES, Zwicker V, Pierce LJ. Oyer RA, et al. J Clin Oncol. 2022 Jul 1;40(19):2163-2171. doi: 10.1200/JCO.22.00754. Epub 2022 May 19. J Clin Oncol. 2022. PMID: 35588469
A concerted commitment across research stakeholders is necessary to increase equity, diversity, and inclusion (EDI) and address barriers to cancer clinical trial recruitment and participation. ...
A concerted commitment across research stakeholders is necessary to increase equity, diversity, and inclusion (EDI) and address barri …
Fluorescence quenching of the N-methylquinolinium cation by pairs of water or alcohol molecules.
Rodríguez-Prieto F, Corbelle CC, Fernández B, Pedro JA, Ríos Rodríguez MC, Mosquera M. Rodríguez-Prieto F, et al. Phys Chem Chem Phys. 2017 Dec 20;20(1):307-316. doi: 10.1039/c7cp07057h. Phys Chem Chem Phys. 2017. PMID: 29205243
We showed also that a low basicity of the hydroxy compound inhibits the quenching process. These results are consistent with the existence of a concerted photoinduced proton-coupled electron transfer (PCET) involving an intermediate complex of the excited quinolinium with …
We showed also that a low basicity of the hydroxy compound inhibits the quenching process. These results are consistent with the existence o …
The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.
Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR. Sowers CR, et al. J Biol Chem. 2018 Apr 6;293(14):5134-5149. doi: 10.1074/jbc.M117.813790. Epub 2018 Feb 14. J Biol Chem. 2018. PMID: 29444822 Free PMC article.
These findings underscore the importance of ER chaperones working in concert to achieve control of insulin production and identify a role for PERK in maintaining a functional balance among these chaperones....
These findings underscore the importance of ER chaperones working in concert to achieve control of insulin production and identify a …
Structures of Adenovirus Incomplete Particles Clarify Capsid Architecture and Show Maturation Changes of Packaging Protein L1 52/55k.
Condezo GN, Marabini R, Ayora S, Carazo JM, Alba R, Chillón M, San Martín C. Condezo GN, et al. J Virol. 2015 Sep;89(18):9653-64. doi: 10.1128/JVI.01453-15. Epub 2015 Jul 15. J Virol. 2015. PMID: 26178997 Free PMC article.
The elaborated capsid architecture is the product of a correspondingly complex assembly process, about which many aspects remain unknown. Genome encapsidation involves the concerted action of five virus proteins, and proteolytic processing by the virus protease is needed t …
The elaborated capsid architecture is the product of a correspondingly complex assembly process, about which many aspects remain unknown. Ge …
The role of conformation in ion permeation in a K+ channel.
Domene C, Vemparala S, Furini S, Sharp K, Klein ML. Domene C, et al. J Am Chem Soc. 2008 Mar 19;130(11):3389-98. doi: 10.1021/ja075164v. Epub 2008 Feb 23. J Am Chem Soc. 2008. PMID: 18293969
In contrast, in our open-state model, three to four K+ ions move in a concerted motion during the permeation process. The selectivity filter, though maintaining a certain degree of flexibility to cope with these cooperative events, appears to be more "symmetrical" and robu …
In contrast, in our open-state model, three to four K+ ions move in a concerted motion during the permeation process. The selectivity …
A general mechanism for the copper- and silver-catalyzed olefin aziridination reactions: concomitant involvement of the singlet and triplet pathways.
Maestre L, Sameera WM, Díaz-Requejo MM, Maseras F, Pérez PJ. Maestre L, et al. J Am Chem Soc. 2013 Jan 30;135(4):1338-48. doi: 10.1021/ja307229e. Epub 2013 Jan 22. J Am Chem Soc. 2013. PMID: 23276287
Data from these experiments seem to be contradictory, as they do not fully support the previously reported concerted or stepwise mechanisms. But theoretical calculations have provided the reaction profiles for both the silver and copper systems with different olefins to sa …
Data from these experiments seem to be contradictory, as they do not fully support the previously reported concerted or stepwise mech …