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Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?
Bjørklund G, Storchylo O, Peana M, Hangan T, Lysiuk R, Lenchyk L, Koshovyi O, Antonyak H, Hudz N, Chirumbolo S. Bjørklund G, et al. Curr Med Chem. 2023 Nov 6. doi: 10.2174/0109298673252993230921073502. Online ahead of print. Curr Med Chem. 2023. PMID: 37933215
BACKGROUND: Propolis and its major phenolic compound, caffeic acid phenethyl ester (CAPE), have garnered considerable scientific interest due to their anti-inflammatory properties and potential therapeutic applications. ...Our search focused on keywords such as cancer, nat …
BACKGROUND: Propolis and its major phenolic compound, caffeic acid phenethyl ester (CAPE), have garnered considerable scientific inte …
New trends in advanced parkinson disease stage therapy.
Kolesárová M, Franko O, Kolesár D, Gažová A, Kyselovič J. Kolesárová M, et al. Ceska Slov Farm. 2023 Winter;72(1):37-44. Ceska Slov Farm. 2023. PMID: 36858978 English.
Data originated from a group of 43 patients with PD, 39% (17) with classic treatment, 23% (10) with intestinal gel of methyl ester levodopa (Duodopa), 19% (8) of patients were using subcutaneous delivery of apomorphine (APO) and the same quantity of patients had undergone …
Data originated from a group of 43 patients with PD, 39% (17) with classic treatment, 23% (10) with intestinal gel of methyl ester le …
Lysosome-Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs.
Daum S, Reshetnikov MSV, Sisa M, Dumych T, Lootsik MD, Bilyy R, Bila E, Janko C, Alexiou C, Herrmann M, Sellner L, Mokhir A. Daum S, et al. Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15545-15549. doi: 10.1002/anie.201706585. Epub 2017 Nov 9. Angew Chem Int Ed Engl. 2017. PMID: 28994179
In particular, known prodrug 4-(N-ferrocenyl-N-benzylaminocarbonyloxymethyl)phenylboronic acid pinacol ester was converted into its lysosome-specific analogue. Since lysosomes contain a higher concentration of active ROS than the cytoplasm, activation of the prodrug was fa …
In particular, known prodrug 4-(N-ferrocenyl-N-benzylaminocarbonyloxymethyl)phenylboronic acid pinacol ester was converted into its l …
Mitochondrial ryanodine-sensitive Ca2+ channels of rat liver.
Kupynyak NI, Ikkert OV, Shlykov SG, Babich LG, Manko VV. Kupynyak NI, et al. Cell Biochem Funct. 2017 Jan;35(1):42-49. doi: 10.1002/cbf.3243. Epub 2017 Jan 3. Cell Biochem Funct. 2017. PMID: 28052355
Mitochondrial membrane potential was measured using a voltage-sensitive fluorescent probe tetramethylrhodamine-methyl-ester (0.1muM) and was analyzed by a flow cytometer. To evaluate the intact mitochondria, we used carbonil cyanide m-chlorophenyl hydrazone (CCCP, 10muM). …
Mitochondrial membrane potential was measured using a voltage-sensitive fluorescent probe tetramethylrhodamine-methyl-ester (0.1muM) …
Thiocyanatoarylation of Methyl Vinyl Ketone under Meerwein Conditions for the Synthesis of 2-Aminothiazole-Based Heterocyclic Systems.
Ostapiuk YV, Barabash OV, Ostapiuk MY, Goreshnik E, Obushak MD, Schmidt A. Ostapiuk YV, et al. Org Lett. 2022 Jul 1;24(25):4575-4579. doi: 10.1021/acs.orglett.2c01677. Epub 2022 Jun 23. Org Lett. 2022. PMID: 35735270
4-Aryl-3-thiocyanatobutan-2-ones were prepared by Meerwein reactions from methyl vinyl ketone and aryldiazonium salts under copper(II) catalysis in 35-75% yields. alpha-Thiocyanato ketones regioselectively react with 1-methyl-3-aminopyrazole forming N-(3-pyrazolyl)-substituted 2- …
4-Aryl-3-thiocyanatobutan-2-ones were prepared by Meerwein reactions from methyl vinyl ketone and aryldiazonium salts under copper(II) catal …
cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation.
Franko A, Kovarova M, Feil S, Feil R, Wagner R, Heni M, Königsrainer A, Ruoß M, Nüssler AK, Weigert C, Häring HU, Lutz SZ, Peter A. Franko A, et al. Metabolism. 2018 Nov;88:22-30. doi: 10.1016/j.metabol.2018.09.001. Epub 2018 Sep 6. Metabolism. 2018. PMID: 30195474 Free article.
Finally, cGKI expression was examined in human liver biopsies covering a wide range of liver fat content. RESULTS: Retinyl-ester concentrations in the liver of cGKI-SM mice were lower compared to wild-type animals, which was associated with disturbed expression of genes in …
Finally, cGKI expression was examined in human liver biopsies covering a wide range of liver fat content. RESULTS: Retinyl-ester conc …
The Tracing of VOC Composition of Acacia Honey During Ripening Stages by Comprehensive Two-Dimensional Gas Chromatography.
Vyviurska O, Chlebo R, Pysarevska S, Špánik I. Vyviurska O, et al. Chem Biodivers. 2016 Oct;13(10):1316-1325. doi: 10.1002/cbdv.201600056. Chem Biodivers. 2016. PMID: 27464259
The most enriched VOC profile was obtained for raw honey before cell capping, where the final composition of lactones was achieved. On the contrary, number of alcohols, esters, and variety of terpenes, as well as their concentration in the honey samples decrease through ri …
The most enriched VOC profile was obtained for raw honey before cell capping, where the final composition of lactones was achieved. On the c …
New Coordination Polymers of Selected Lanthanides with 1,2-Phenylenediacetate Linker: Structures, Thermal and Luminescence Properties.
Łyszczek R, Rusinek I, Ostasz A, Sienkiewicz-Gromiuk J, Vlasyuk D, Groszek M, Lipke A, Pavlyuk O. Łyszczek R, et al. Materials (Basel). 2021 Aug 27;14(17):4871. doi: 10.3390/ma14174871. Materials (Basel). 2021. PMID: 34500958 Free PMC article.
Pyrolysis of complexes takes place with the formation of such gaseous products as DMF, carbon oxides, ortho-xylene, ethers, water, carboxylic acids, and esters. The complexes of Eu and Tb exhibit characteristic luminescence in the VIS region, while the erbium complex emits …
Pyrolysis of complexes takes place with the formation of such gaseous products as DMF, carbon oxides, ortho-xylene, ethers, water, carboxyli …
Inhibition of AChE by malathion and some structurally similar compounds.
Krstić DZ, Colović M, Kralj MB, Franko M, Krinulović K, Trebse P, Vasić V. Krstić DZ, et al. J Enzyme Inhib Med Chem. 2008 Aug;23(4):562-73. doi: 10.1080/14756360701632031. J Enzyme Inhib Med Chem. 2008. PMID: 18608787 Free article.
However, the products formed due to photoinduced degradation, phosphorodithioic O,O,S-trimethyl ester and O,O-dimethyl thiophosphate, did not noticeably affect enzymatic activity, while diethyl maleate inhibited AChE activity at concentrations > 10mM. ...The presence of …
However, the products formed due to photoinduced degradation, phosphorodithioic O,O,S-trimethyl ester and O,O-dimethyl thiophosphate, …
Comparison of photocatalysis and photolysis of malathion, isomalathion, malaoxon, and commercial malathion--products and toxicity studies.
Bavcon Kralj M, Cernigoj U, Franko M, Trebse P. Bavcon Kralj M, et al. Water Res. 2007 Nov;41(19):4504-14. doi: 10.1016/j.watres.2007.06.016. Epub 2007 Jun 15. Water Res. 2007. PMID: 17624398
Oxidation and isomerization were found as the main reactions of butenedioc acid diethyl esters and their analogs. The formation of malaoxon, isomalathion or trimethyl phosphate esters correlated well with the induced toxicity (inhibition of acetylcholinesterase), wh …
Oxidation and isomerization were found as the main reactions of butenedioc acid diethyl esters and their analogs. The formation of ma …
13 results