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Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4(3H)-one: Synthesis and In Vitro Activities Evaluation.
Pele R, Marc G, Ionuț I, Nastasă C, Fizeșan I, Pîrnău A, Vlase L, Palage M, Oniga S, Oniga O. Pele R, et al. Pharmaceutics. 2022 Dec 30;15(1):136. doi: 10.3390/pharmaceutics15010136. Pharmaceutics. 2022. PMID: 36678764 Free PMC article.
The development of hybrid molecules with significant human therapeutic properties is one of the main approaches of pharmaceutical research. One of the most important pharmacophores is the quinazolin-4(3H)-one heterocycle moiety, due to its wide range of biolo …
The development of hybrid molecules with significant human therapeutic properties is one of the main approaches of pharmaceutical res …
Gastrointestinal hormones and bariatric surgery-induced weight loss.
Ionut V, Burch M, Youdim A, Bergman RN. Ionut V, et al. Obesity (Silver Spring). 2013 Jun;21(6):1093-103. doi: 10.1002/oby.20364. Obesity (Silver Spring). 2013. PMID: 23512841 Free PMC article. Review.
Bariatric surgery has a profound and durable effect on weight loss, being to date one of the most successful interventions for obesity. OBJECTIVE: To provide updates to the possible role of gut hormones in post bariatric surgery weight loss and weight loss maintenance. ...
Bariatric surgery has a profound and durable effect on weight loss, being to date one of the most successful interventions for obesit …
Synthesis of New Phenolic Derivatives of Quinazolin-4(3H)-One as Potential Antioxidant Agents-In Vitro Evaluation and Quantum Studies.
Pele R, Marc G, Stana A, Ionuț I, Nastasă C, Tiperciuc B, Oniga I, Pîrnău A, Vlase L, Oniga O. Pele R, et al. Molecules. 2022 Apr 18;27(8):2599. doi: 10.3390/molecules27082599. Molecules. 2022. PMID: 35458796 Free PMC article.
Therefore, we synthesized four series of new hybrid molecules bearing the quinazolin-4-one and phenol scaffolds. Their antioxidant potential was evaluated in vitro, considering different possible mechanisms of action: hydrogen atom transfer, ability to donate electrons and …
Therefore, we synthesized four series of new hybrid molecules bearing the quinazolin-4-one and phenol scaffolds. Their antioxidant po …
Mechanisms responsible for excess weight loss after bariatric surgery.
Ionut V, Bergman RN. Ionut V, et al. J Diabetes Sci Technol. 2011 Sep 1;5(5):1263-82. doi: 10.1177/193229681100500536. J Diabetes Sci Technol. 2011. PMID: 22027328 Free PMC article. Review.
Because obesity is an important risk factor for type 2 diabetes and other chronic diseases, it is important to develop approaches to counter the rapid increase in adiposity. One approach is bariatric surgery, the most successful clinical intervention known for treating obe …
Because obesity is an important risk factor for type 2 diabetes and other chronic diseases, it is important to develop approaches to counter …
Synthesis, In Vivo Anticonvulsant Activity Evaluation and In Silico Studies of Some Quinazolin-4(3H)-One Derivatives.
Pele R, Marc G, Mogoșan C, Apan A, Ionuț I, Tiperciuc B, Moldovan C, Araniciu C, Oniga I, Pîrnău A, Vlase L, Oniga O. Pele R, et al. Molecules. 2024 Apr 24;29(9):1951. doi: 10.3390/molecules29091951. Molecules. 2024. PMID: 38731442 Free PMC article.
Two series, "a" and "b", each consisting of nine chemical compounds, with 2,3-disubstituted quinazolin-4(3H)-one scaffold, were synthesized and evaluated for their anticonvulsant activity. They were investigated as dual potential positive allosteric modulators of the GABA( …
Two series, "a" and "b", each consisting of nine chemical compounds, with 2,3-disubstituted quinazolin-4(3H)-one scaffold, were synth …
The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation.
Gordon RA, Nguyen Y, Foulquier N, Beydon M, Gheita TA, Hajji R, Sahbudin I, Hoi A, Ng WF, Mendonça JA, Wallace DJ, Shea B, Bruyn GA, Goodman SM, Fisher BA, Baldini C, Torralba KD, Bootsma H, Akpek EK, Karakus S, Baer AN, Chakravarty SD, Terslev L, D'Agostino MA, Mariette X, DiRenzo D, Rasmussen A, Papas A, Montoya C, Arends S, Yusof MYM, Pintilie I, Warner BM, Hammitt KM, Strand V, Bouillot C, Tugwell P, Inanc N, Andreu JL, Wahren-Herlenius M, Devauchelle-Pensec V, Shiboski CH, Benyoussef A, Masli S, Lee AYS, Cornec D, Bowman S, Rischmueller M, McCoy SS, Seror R. Gordon RA, et al. Semin Arthritis Rheum. 2024 Apr;65:152378. doi: 10.1016/j.semarthrit.2024.152378. Epub 2024 Jan 23. Semin Arthritis Rheum. 2024. PMID: 38310657
SjD can affect any organ system with a variety of presentations across individuals. This heterogeneity is one of the major barriers for developing effective disease modifying treatments. ...
SjD can affect any organ system with a variety of presentations across individuals. This heterogeneity is one of the major barriers f …
Study of the Relationships between the Structure, Lipophilicity and Biological Activity of Some Thiazolyl-carbonyl-thiosemicarbazides and Thiazolyl-azoles.
Tamaian R, Moţ A, Silaghi-Dumitrescu R, Ionuţ I, Stana A, Oniga O, Nastasă C, Benedec D, Tiperciuc B. Tamaian R, et al. Molecules. 2015 Dec 11;20(12):22188-201. doi: 10.3390/molecules201219841. Molecules. 2015. PMID: 26690402 Free PMC article.
Lipophilicity, as one of the most important physicochemical parameters of bioactive molecules, was investigated for twenty-two thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles. ...
Lipophilicity, as one of the most important physicochemical parameters of bioactive molecules, was investigated for twenty-two thiazo …
Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors.
Stana A, Vodnar DC, Tamaian R, Pîrnău A, Vlase L, Ionuț I, Oniga O, Tiperciuc B. Stana A, et al. Int J Mol Sci. 2017 Jan 17;18(1):177. doi: 10.3390/ijms18010177. Int J Mol Sci. 2017. PMID: 28106743 Free PMC article.
All the synthesized compounds were physico-chemically characterized and the IR (infrared spectra), 1H NMR (proton nuclear magnetic resonance), (13)C NMR (carbon nuclear magnetic resonance) and MS (mass spectrometry) data were consistent with the assigned structures. The synthesiz …
All the synthesized compounds were physico-chemically characterized and the IR (infrared spectra), 1H NMR (proton nuclear magnetic resonance …
An Overview of the Structure-Activity Relationship in Novel Antimicrobial Thiazoles Clubbed with Various Heterocycles (2017-2023).
Ungureanu D, Tiperciuc B, Nastasă C, Ionuț I, Marc G, Oniga I, Oniga O. Ungureanu D, et al. Pharmaceutics. 2024 Jan 9;16(1):89. doi: 10.3390/pharmaceutics16010089. Pharmaceutics. 2024. PMID: 38258100 Free PMC article. Review.
Antimicrobial resistance is an increasing problem for global public health. One of the strategies to combat this issue is the synthesis of novel antimicrobials through rational drug design based on extensive structure-activity relationship studies. ...
Antimicrobial resistance is an increasing problem for global public health. One of the strategies to combat this issue is the synthes …
Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring.
Larkin ME, Nathan DM, Bebu I, Krause-Steinrauf H, Herman WH, Higgins JM, Tiktin M, Cohen RM, Lund C, Bergenstal RM, Johnson ML, Arends V; GRADE Research Group. Larkin ME, et al. Diabetes Technol Ther. 2019 Dec;21(12):682-690. doi: 10.1089/dia.2019.0202. Epub 2019 Sep 4. Diabetes Technol Ther. 2019. PMID: 31393176 Free PMC article.
Background: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) study has enrolled a racially and ethnically diverse population with type 2 diabetes, performed extensive phenotyping, and randomly assigned the participants to one of four secon …
Background: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) study has enrolled a racially and ethnically …
23 results