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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1973 6
1974 1
1976 1
1977 2
1979 3
1980 1
1981 2
1982 2
1983 4
1984 4
1985 1
1986 2
1987 1
1988 1
1989 1
1991 1
1992 1
1993 1
1994 1
1995 1
1996 1
1997 1
1998 1
1999 2
2001 3
2002 2
2004 2
2005 1
2006 2
2007 4
2008 1
2009 1
2010 4
2011 4
2012 6
2013 2
2014 3
2015 5
2016 2
2017 3
2018 1
2019 4
2020 4
2021 5
2022 4
2023 10
2024 5

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113 results

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Page 1
Estrogen receptors and the aging brain.
Maioli S, Leander K, Nilsson P, Nalvarte I. Maioli S, et al. Essays Biochem. 2021 Dec 17;65(6):913-925. doi: 10.1042/EBC20200162. Essays Biochem. 2021. PMID: 34623401 Free PMC article. Review.
This review will discuss what this drop entails in terms of modulating neuroprotection and resilience in the aging brain downstream of spatiotemporal estrogen receptor alpha (ERalpha) and beta (ERbeta) signaling, as well as in terms of the sex differences observed in Alzhe …
This review will discuss what this drop entails in terms of modulating neuroprotection and resilience in the aging brain downstream o …
Brain Renin-Angiotensin System as Novel and Potential Therapeutic Target for Alzheimer's Disease.
Loera-Valencia R, Eroli F, Garcia-Ptacek S, Maioli S. Loera-Valencia R, et al. Int J Mol Sci. 2021 Sep 20;22(18):10139. doi: 10.3390/ijms221810139. Int J Mol Sci. 2021. PMID: 34576302 Free PMC article. Review.
The activation of the brain renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology of cognition. ...We review existent medications for RASi therapy and show research on novel drugs, including small molecules and nanodelivery strategies that can target t …
The activation of the brain renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology of cognition. ...We review exi …
27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes.
Alanko V, Gaminde-Blasco A, Quintela-López T, Loera-Valencia R, Solomon A, Björkhem I, Cedazo-Minguez A, Maioli S, Tabacaru G, Latorre-Leal M, Matute C, Kivipelto M, Alberdi E, Sandebring-Matton A. Alanko V, et al. Glia. 2023 Jun;71(6):1414-1428. doi: 10.1002/glia.24348. Epub 2023 Feb 13. Glia. 2023. PMID: 36779429
Oxidized cholesterol metabolite 27-hydroxycholesterol (27-OH) is a potential link between hypercholesterolemia and neurodegenerative diseases since unlike peripheral cholesterol, 27-OH is transported across the blood-brain barrier. However, the effects of high 27-OH levels …
Oxidized cholesterol metabolite 27-hydroxycholesterol (27-OH) is a potential link between hypercholesterolemia and neurodegenerative disease …
MicroRNAs, Stem Cells in Bipolar Disorder, and Lithium Therapeutic Approach.
Coradduzza D, Garroni G, Congiargiu A, Balzano F, Cruciani S, Sedda S, Nivoli A, Maioli M. Coradduzza D, et al. Int J Mol Sci. 2022 Sep 10;23(18):10489. doi: 10.3390/ijms231810489. Int J Mol Sci. 2022. PMID: 36142403 Free PMC article. Review.
Recently, microRNAs (miRNAs), a class of epigenetic regulators of gene expression playing a central role in brain development and plasticity, have been related to several neuropsychiatric disorders, including BD. Moreover, an alteration in the number/distribution and diffe …
Recently, microRNAs (miRNAs), a class of epigenetic regulators of gene expression playing a central role in brain development and pla …
A ZFHX4 mutation associated with a recognizable neuropsychological and facial phenotype.
Fontana P, Ginevrino M, Bejo K, Cantalupo G, Ciavarella M, Lombardi C, Maioli M, Scarano F, Costabile C, Novelli A, Lonardo F. Fontana P, et al. Eur J Med Genet. 2021 Nov;64(11):104321. doi: 10.1016/j.ejmg.2021.104321. Epub 2021 Aug 27. Eur J Med Genet. 2021. PMID: 34461323
This gene encodes for a transcription factor involved in the development of several embryonal processes, including brain differentiation. Patients with 8q21.11 deletions usually show intellectual disability, short stature, peculiar facial features, and severe eye abnormali …
This gene encodes for a transcription factor involved in the development of several embryonal processes, including brain differentiat …
Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison.
Goikolea J, Latorre-Leal M, Tsagkogianni C, Pikkupeura S, Gulyas B, Cedazo-Minguez A, Loera-Valencia R, Björkhem I, Rodriguez Rodriguez P, Maioli S. Goikolea J, et al. J Steroid Biochem Mol Biol. 2023 Nov;234:106387. doi: 10.1016/j.jsbmb.2023.106387. Epub 2023 Aug 28. J Steroid Biochem Mol Biol. 2023. PMID: 37648096 Free article.
The oxysterol 27-hydroxycholesterol (27OHC) is produced by the enzyme sterol 27-hydroxylase (Cyp27A1) and is mainly catabolized to 7alpha-Hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) by the enzyme cytochrome P-450 oxysterol 7alpha-hydroxylase (Cyp7B1). 27OHC is mostly produced in t …
The oxysterol 27-hydroxycholesterol (27OHC) is produced by the enzyme sterol 27-hydroxylase (Cyp27A1) and is mainly catabolized to 7alpha-Hy …
Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study.
Petek B, Häbel H, Xu H, Villa-Lopez M, Kalar I, Hoang MT, Maioli S, Pereira JB, Mostafaei S, Winblad B, Gregoric Kramberger M, Eriksdotter M, Garcia-Ptacek S. Petek B, et al. Alzheimers Res Ther. 2023 Dec 20;15(1):220. doi: 10.1186/s13195-023-01360-0. Alzheimers Res Ther. 2023. PMID: 38115091 Free PMC article.
BACKGROUND: Disturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer's disease (AD). ...
BACKGROUND: Disturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer's disease (AD). ...
Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment.
Loera-Valencia R, Goikolea J, Parrado-Fernandez C, Merino-Serrais P, Maioli S. Loera-Valencia R, et al. J Steroid Biochem Mol Biol. 2019 Jun;190:104-114. doi: 10.1016/j.jsbmb.2019.03.003. Epub 2019 Mar 13. J Steroid Biochem Mol Biol. 2019. PMID: 30878503 Free article. Review.
Years of research have shown a strong correlation between blood hypercholesterolemia and AD, however cholesterol is not able to cross the Blood Brain Barrier (BBB) into the brain. Cholesterol lowering therapies have shown mixed results in cognitive performance in AD …
Years of research have shown a strong correlation between blood hypercholesterolemia and AD, however cholesterol is not able to cross the Bl …
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.
Latorre-Leal M, Rodriguez-Rodriguez P, Franchini L, Nikolidakis O, Daniilidou M, Delac L, Varshney MK, Arroyo-García LE, Eroli F, Winblad B, Blennow K, Zetterberg H, Kivipelto M, Pacciarini M, Wang Y, Griffiths WJ, Björkhem I, Matton A, Nalvarte I, Merino-Serrais P, Cedazo-Minguez A, Maioli S. Latorre-Leal M, et al. Sci Adv. 2024 Jan 26;10(4):eadj1354. doi: 10.1126/sciadv.adj1354. Epub 2024 Jan 24. Sci Adv. 2024. PMID: 38266095 Free PMC article.
The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol into 24S-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and reduced CYP46A1 levels are observed in Alzheimer's disease (AD). ...
The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol into 24S-hydroxycholesterol (24OH). Dysregu …
Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities.
Daniilidou M, Eroli F, Alanko V, Goikolea J, Latorre-Leal M, Rodriguez-Rodriguez P, Griffiths WJ, Wang Y, Pacciarini M, Brinkmalm A, Zetterberg H, Blennow K, Rosenberg A, Bogdanovic N, Winblad B, Kivipelto M, Ibghi D, Cedazo-Minguez A, Maioli S, Matton A. Daniilidou M, et al. Brain Commun. 2023 Aug 25;5(5):fcad228. doi: 10.1093/braincomms/fcad228. eCollection 2023. Brain Commun. 2023. PMID: 37680670 Free PMC article.
113 results