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Δ-9-tetrahydrocannabinol dose increase leads to warfarin drug interaction and elevated INR.
Brown GW, Bellnier TJ, Janda M, Miskowitz K. Brown GW, et al. J Am Pharm Assoc (2003). 2021 Jan-Feb;61(1):e57-e60. doi: 10.1016/j.japh.2020.07.028. Epub 2020 Aug 20. J Am Pharm Assoc (2003). 2021. PMID: 32828704
The supratherapeutic level occurred when the patient was self-titrating his dose of THC and scored an 8, or "probable," on the Naranjo Adverse Drug Effect Probability Scale. PRACTICE IMPLICATIONS: Warfarin and cannabinoids such as THC are both metabolized by cytochrome P45 …
The supratherapeutic level occurred when the patient was self-titrating his dose of THC and scored an 8, or "probable," on the Naranjo …