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Page 1
The comparison of the anatomic stage and pathological prognostic stage according to the AJCC 8th edition for the prognosis in Japanese breast cancer patients: data from a single institution.
Tokunaga E, Ijichi H, Tajiri W, Masuda T, Takizawa K, Ueo H, Koga C, Tanaka J, Nakamura Y, Ohno S, Taguchi K, Okamoto M. Tokunaga E, et al. Among authors: ijichi h. Breast Cancer. 2020 Nov;27(6):1137-1146. doi: 10.1007/s12282-020-01116-w. Epub 2020 May 29. Breast Cancer. 2020. PMID: 32472474 Free PMC article.
Clinical usefulness of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for patients with primary liver cancer with special reference to rare histological types, hepatocellular carcinoma with sarcomatous change and combined hepatocellular and cholangiocarcinoma.
Ijichi H, Shirabe K, Taketomi A, Yoshizumi T, Ikegami T, Mano Y, Aishima S, Abe K, Honda H, Maehara Y. Ijichi H, et al. Hepatol Res. 2013 May;43(5):481-7. doi: 10.1111/j.1872-034X.2012.01107.x. Epub 2012 Nov 12. Hepatol Res. 2013. PMID: 23145869
Is graft size a major risk factor in living-donor adult liver transplantation?
Shimada M, Ijichi H, Yonemura Y, Harada N, Shiotani S, Ninomiya M, Yoshizumi T, Soejima Y, Suehiro T, Maehara Y. Shimada M, et al. Among authors: ijichi h. Transpl Int. 2004 Jul;17(6):310-6. doi: 10.1007/s00147-004-0720-9. Epub 2004 Jun 22. Transpl Int. 2004. PMID: 15221124 Free article.
Estimation of standard liver volume for Japanese adults.
Yoshizumi T, Taketomi A, Kayashima H, Yonemura Y, Harada N, Ijichi H, Soejima Y, Nishizaki T, Maehara Y. Yoshizumi T, et al. Among authors: ijichi h. Transplant Proc. 2008 Jun;40(5):1456-60. doi: 10.1016/j.transproceed.2008.02.082. Transplant Proc. 2008. PMID: 18589128
Pure laparoscopic right hepatectomy in the semi-prone position using the intrahepatic Glissonian approach and a modified hanging maneuver to minimize intraoperative bleeding.
Ikeda T, Yonemura Y, Ueda N, Kabashima A, Shirabe K, Taketomi A, Yoshizumi T, Uchiyama H, Harada N, Ijichi H, Kakeji Y, Morita M, Tsujitani S, Maehara Y. Ikeda T, et al. Among authors: ijichi h. Surg Today. 2011 Dec;41(12):1592-8. doi: 10.1007/s00595-010-4479-6. Epub 2011 Oct 4. Surg Today. 2011. PMID: 21969190
Left lobe living donor liver transplantation in adults.
Soejima Y, Shirabe K, Taketomi A, Yoshizumi T, Uchiyama H, Ikegami T, Ninomiya M, Harada N, Ijichi H, Maehara Y. Soejima Y, et al. Among authors: ijichi h. Am J Transplant. 2012 Jul;12(7):1877-85. doi: 10.1111/j.1600-6143.2012.04022.x. Epub 2012 Mar 19. Am J Transplant. 2012. PMID: 22429497 Free article.
Combination of serum human satellite RNA and miR-21-5p levels as a biomarker for pancreatic cancer.
Seimiya T, Suzuki T, Iwata T, Kishikawa T, Sekiba K, Shibata C, Ishigaki K, Fujiwara H, Oyama H, Kanai S, Sato T, Nakai Y, Ishibashi R, Moriyama M, Nakagawa R, Ijichi H, Otsuka M, Koike K. Seimiya T, et al. Among authors: ijichi h. iScience. 2023 Jan 19;26(2):106021. doi: 10.1016/j.isci.2023.106021. eCollection 2023 Feb 17. iScience. 2023. PMID: 36798431 Free PMC article.
Clinical Outcomes of Intraductal Papillary Mucinous Neoplasms With Dilatation of the Main Pancreatic Duct.
Hamada T, Oyama H, Nakai Y, Tange S, Arita J, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kawaguchi Y, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Tanaka M, Tateishi K, Ushiku T, Hasegawa K, Fujishiro M. Hamada T, et al. Among authors: ijichi h. Clin Gastroenterol Hepatol. 2023 Jul;21(7):1792-1801.e3. doi: 10.1016/j.cgh.2023.01.032. Epub 2023 Feb 12. Clin Gastroenterol Hepatol. 2023. PMID: 36787835
HNF1B-driven three-dimensional chromatin structure for molecular classification in pancreatic cancers.
Kato H, Tateishi K, Iwadate D, Yamamoto K, Fujiwara H, Nakatsuka T, Kudo Y, Hayakawa Y, Ijichi H, Otsuka M, Kishikawa T, Takahashi R, Miyabayashi K, Nakai Y, Hirata Y, Toyoda A, Morishita S, Fujishiro M. Kato H, et al. Among authors: ijichi h. Cancer Sci. 2023 Apr;114(4):1672-1685. doi: 10.1111/cas.15690. Epub 2022 Dec 25. Cancer Sci. 2023. PMID: 36511816 Free PMC article.
The Role of the Microbiome in Pancreatic Cancer.
Miyabayashi K, Ijichi H, Fujishiro M. Miyabayashi K, et al. Among authors: ijichi h. Cancers (Basel). 2022 Sep 15;14(18):4479. doi: 10.3390/cancers14184479. Cancers (Basel). 2022. PMID: 36139638 Free PMC article. Review.
MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages.
Kato H, Tateishi K, Fujiwara H, Nakatsuka T, Yamamoto K, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Ijichi H, Otsuka M, Iwadate D, Oyama H, Kanai S, Noguchi K, Suzuki T, Sato T, Hakuta R, Ishigaki K, Saito K, Saito T, Takahara N, Kishikawa T, Hamada T, Takahashi R, Miyabayashi K, Mizuno S, Kogure H, Nakai Y, Hirata Y, Toyoda A, Ichikawa K, Qu W, Morishita S, Arita J, Tanaka M, Ushiku T, Hasegawa K, Fujishiro M, Koike K. Kato H, et al. Among authors: ijichi h. Gastroenterology. 2022 Apr;162(4):1272-1287.e16. doi: 10.1053/j.gastro.2021.12.254. Epub 2021 Dec 22. Gastroenterology. 2022. PMID: 34953915
ABO Blood Group and Risk of Pancreatic Carcinogenesis in Intraductal Papillary Mucinous Neoplasms.
Hamada T, Oyama H, Nakai Y, Tada M, Koh H, Tateishi K, Arita J, Hakuta R, Ijichi H, Ishigaki K, Kawaguchi Y, Kogure H, Mizuno S, Morikawa T, Saito K, Saito T, Sato T, Takagi K, Takahara N, Takahashi R, Tanaka A, Tanaka M, Ushiku T, Hasegawa K, Koike K. Hamada T, et al. Among authors: ijichi h. Cancer Epidemiol Biomarkers Prev. 2021 May;30(5):1020-1028. doi: 10.1158/1055-9965.EPI-20-1581. Epub 2021 Mar 2. Cancer Epidemiol Biomarkers Prev. 2021. PMID: 33653811
Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis.
Nakatsuka T, Tateishi K, Kato H, Fujiwara H, Yamamoto K, Kudo Y, Nakagawa H, Tanaka Y, Ijichi H, Ikenoue T, Ishizawa T, Hasegawa K, Tachibana M, Shinkai Y, Koike K. Nakatsuka T, et al. Among authors: ijichi h. Cell Death Dis. 2021 Jan 19;12(1):99. doi: 10.1038/s41419-020-03381-1. Cell Death Dis. 2021. PMID: 33468997 Free PMC article.
Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer.
Takahashi R, Ijichi H, Sano M, Miyabayashi K, Mohri D, Kim J, Kimura G, Nakatsuka T, Fujiwara H, Yamamoto K, Kudo Y, Tanaka Y, Tateishi K, Nakai Y, Morishita Y, Soma K, Takeda N, Moses HL, Isayama H, Koike K. Takahashi R, et al. Among authors: ijichi h. Sci Rep. 2020 Dec 3;10(1):21194. doi: 10.1038/s41598-020-78320-3. Sci Rep. 2020. PMID: 33273652 Free PMC article.
Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome.
Hara H, Maemura S, Fujiwara T, Takeda N, Ishii S, Yagi H, Suzuki T, Harada M, Toko H, Kanaya T, Ijichi H, Moses HL, Takimoto E, Morita H, Akazawa H, Komuro I. Hara H, et al. Among authors: ijichi h. PLoS One. 2020 Nov 11;15(11):e0239908. doi: 10.1371/journal.pone.0239908. eCollection 2020. PLoS One. 2020. PMID: 33175881 Free PMC article.
Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis.
Kato H, Tateishi K, Fujiwara H, Ijichi H, Yamamoto K, Nakatsuka T, Kakiuchi M, Sano M, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Otsuka M, Hirata Y, Tachibana M, Shinkai Y, Koike K. Kato H, et al. Among authors: ijichi h. Cancer Genomics Proteomics. 2020 Nov-Dec;17(6):695-705. doi: 10.21873/cgp.20224. Cancer Genomics Proteomics. 2020. PMID: 33099471 Free PMC article.
A retrospective comparative study of S-IROX and modified FOLFIRINOX for patients with advanced pancreatic cancer refractory to gemcitabine plus nab-paclitaxel.
Saito K, Nakai Y, Takahara N, Ishigaki K, Suzuki Y, Inokuma A, Noguchi K, Kanai S, Sato T, Hakuta R, Saito T, Hamada T, Mizuno S, Kogure H, Ijichi H, Tateishi K, Koike K. Saito K, et al. Among authors: ijichi h. Invest New Drugs. 2021 Apr;39(2):605-613. doi: 10.1007/s10637-020-01022-0. Epub 2020 Oct 23. Invest New Drugs. 2021. PMID: 33094362
Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism.
Sano M, Takahashi R, Ijichi H, Ishigaki K, Yamada T, Miyabayashi K, Kimura G, Mizuno S, Kato H, Fujiwara H, Nakatsuka T, Tanaka Y, Kim J, Masugi Y, Morishita Y, Tanaka M, Ushiku T, Nakai Y, Tateishi K, Ishii Y, Isayama H, Moses HL, Koike K. Sano M, et al. Among authors: ijichi h. Gut. 2021 Sep;70(9):1713-1723. doi: 10.1136/gutjnl-2020-320608. Epub 2020 Oct 21. Gut. 2021. PMID: 33087490
Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation.
Fujiwara H, Tateishi K, Misumi K, Hayashi A, Igarashi K, Kato H, Nakatsuka T, Suzuki N, Yamamoto K, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Ijichi H, Kogure H, Nakai Y, Isayama H, Hasegawa K, Fukayama M, Soga T, Koike K. Fujiwara H, et al. Among authors: ijichi h. Sci Rep. 2019 Dec 11;9(1):18859. doi: 10.1038/s41598-019-55211-w. Sci Rep. 2019. PMID: 31827136 Free PMC article.
Late-Evening Carbohydrate and Branched-Chain Amino Acid Snacks Improve the Nutritional Status of Patients Undergoing Hepatectomy Based on Bioelectrical Impedance Analysis of Body Composition.
Kobayashi K, Kaneko J, Yamaguchi T, Kawaguchi Y, Arita J, Akamatsu N, Ishizawa T, Sekine R, Ijichi H, Kubota N, Fukatsu K, Kokudo N, Hasegawa K. Kobayashi K, et al. Among authors: ijichi h. Gastrointest Tumors. 2019 Oct;6(3-4):81-91. doi: 10.1159/000501452. Epub 2019 Aug 29. Gastrointest Tumors. 2019. PMID: 31768352 Free PMC article.
Indirubin 3'-Oxime Inhibits Migration, Invasion, and Metastasis InVivo in Mice Bearing Spontaneously Occurring Pancreatic Cancer via Blocking the RAF/ERK, AKT, and SAPK/JNK Pathways.
Ichimaru Y, Sano M, Kajiwara I, Tobe T, Yoshioka H, Hayashi K, Ijichi H, Miyairi S. Ichimaru Y, et al. Among authors: ijichi h. Transl Oncol. 2019 Dec;12(12):1574-1582. doi: 10.1016/j.tranon.2019.08.010. Epub 2019 Oct 28. Transl Oncol. 2019. PMID: 31671317 Free PMC article.
Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K. Oyama H, et al. Among authors: ijichi h. Gastroenterology. 2020 Jan;158(1):226-237.e5. doi: 10.1053/j.gastro.2019.08.032. Epub 2019 Aug 29. Gastroenterology. 2020. PMID: 31473224
Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus.
Mizuno S, Isayama H, Nakai Y, Ishigaki K, Saito K, Sato T, Takeda T, Hakuta R, Saito T, Takahara N, Kogure H, Ijichi H, Tateishi K, Tada M, Shikata N, Tagami T, Kikuchi S, Yamamoto H, Yamakado M, Koike K. Mizuno S, et al. Among authors: ijichi h. Pancreatology. 2019 Jul;19(5):695-698. doi: 10.1016/j.pan.2019.07.002. Epub 2019 Jul 13. Pancreatology. 2019. PMID: 31320196
Blocking CXCLs-CXCR2 axis in tumor-stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment.
Sano M, Ijichi H, Takahashi R, Miyabayashi K, Fujiwara H, Yamada T, Kato H, Nakatsuka T, Tanaka Y, Tateishi K, Morishita Y, Moses HL, Isayama H, Koike K. Sano M, et al. Among authors: ijichi h. Oncogenesis. 2019 Jan 18;8(2):8. doi: 10.1038/s41389-018-0117-8. Oncogenesis. 2019. PMID: 30659170 Free PMC article.
Effect of home enteral nutrition after pancreaticoduodenectomy.
Ito D, Arita J, Yamamoto M, Akamatsu N, Kaneko J, Ijichi H, Kubota N, Sakamoto Y, Kokudo N, Hasegawa K. Ito D, et al. Among authors: ijichi h. Nutrition. 2019 Apr;60:206-211. doi: 10.1016/j.nut.2018.10.007. Epub 2018 Oct 10. Nutrition. 2019. PMID: 30616102
A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer.
Saito K, Isayama H, Nakai Y, Takahara N, Ishigaki K, Takeda T, Hakuta R, Saito T, Uchino R, Kishikawa T, Hamada T, Mizuno S, Sasaki T, Kogure H, Matsubara S, Yamamoto N, Ijichi H, Tateishi K, Tada M, Koike K. Saito K, et al. Among authors: ijichi h. Invest New Drugs. 2019 Apr;37(2):338-344. doi: 10.1007/s10637-018-0691-9. Epub 2018 Nov 9. Invest New Drugs. 2019. PMID: 30411217 Clinical Trial.
Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease.
Ihara S, Hirata Y, Hikiba Y, Yamashita A, Tsuboi M, Hata M, Konishi M, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K. Ihara S, et al. Among authors: ijichi h. J Crohns Colitis. 2018 Nov 9;12(10):1219-1231. doi: 10.1093/ecco-jcc/jjy088. J Crohns Colitis. 2018. PMID: 29917067
A phase II trial of gemcitabine, S-1 and LV combination (GSL) neoadjuvant chemotherapy for patients with borderline resectable and locally advanced pancreatic cancer.
Saito K, Isayama H, Sakamoto Y, Nakai Y, Ishigaki K, Tanaka M, Watadani T, Arita J, Takahara N, Mizuno S, Kogure H, Ijichi H, Tateishi K, Tada M, Hasegawa K, Fukayama M, Kokudo N, Koike K. Saito K, et al. Among authors: ijichi h. Med Oncol. 2018 May 30;35(7):100. doi: 10.1007/s12032-018-1158-8. Med Oncol. 2018. PMID: 29846849 Clinical Trial.
Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.
Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, Koike K. Nakatsuka T, et al. Among authors: ijichi h. Oncogene. 2017 Nov 9;36(45):6262-6271. doi: 10.1038/onc.2017.222. Epub 2017 Jul 10. Oncogene. 2017. PMID: 28692045
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.
Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K. Nakagawa H, et al. Among authors: ijichi h. Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3806-E3815. doi: 10.1073/pnas.1619416114. Epub 2017 Apr 24. Proc Natl Acad Sci U S A. 2017. PMID: 28439013 Free PMC article.
Corrigendum: A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.
Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y. Ikenoue T, et al. Among authors: ijichi h. Sci Rep. 2017 Jan 3;7:39567. doi: 10.1038/srep39567. Sci Rep. 2017. PMID: 28045050 Free PMC article. No abstract available.
No Survival Benefit from the Inhibition of Renin-Angiotensin System in Biliary Tract Cancer.
Nakai Y, Isayama H, Sasaki T, Takahara N, Saito K, Takeda T, Umefune G, Saito T, Takagi K, Watanabe T, Hamada T, Uchino R, Mizuno S, Yamamoto K, Kogure H, Matsubara S, Yamamoto N, Ijichi H, Tateishi K, Tada M, Koike K. Nakai Y, et al. Among authors: ijichi h. Anticancer Res. 2016 Sep;36(9):4965-70. doi: 10.21873/anticanres.11065. Anticancer Res. 2016. PMID: 27630357
Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer.
Yamamoto K, Tateishi K, Kudo Y, Hoshikawa M, Tanaka M, Nakatsuka T, Fujiwara H, Miyabayashi K, Takahashi R, Tanaka Y, Ijichi H, Nakai Y, Isayama H, Morishita Y, Aoki T, Sakamoto Y, Hasegawa K, Kokudo N, Fukayama M, Koike K. Yamamoto K, et al. Among authors: ijichi h. Oncotarget. 2016 Sep 20;7(38):61469-61484. doi: 10.18632/oncotarget.11129. Oncotarget. 2016. PMID: 27528027 Free PMC article.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Asaoka Y, Ijichi H, Koike K. Asaoka Y, et al. Among authors: ijichi h. N Engl J Med. 2015 Nov 12;373(20):1979. doi: 10.1056/NEJMc1510353. N Engl J Med. 2015. PMID: 26559583 No abstract available.
[IPMN and pancreatic cyst as high risk of pancreatic cancer].
Tada M, Takagi K, Kawakubo K, Hakuta R, Ishigaki K, Takeda T, Fujiwara H, Umefune G, Saito K, Saito T, Watanabe T, Akiyama D, Uchino R, Kishikawa T, Takahara N, Takahashi R, Yamamoto K, Hamada T, Mizuno S, Miyabayashi K, Mohri D, Matsubara S, Kogure H, Nakai Y, Yamamoto N, Sasaki T, Sasahira N, Hirano K, Ijichi H, Tateishi K, Isayama H, Koike K. Tada M, et al. Among authors: ijichi h. Nihon Shokakibyo Gakkai Zasshi. 2015 Aug;112(8):1474-8. doi: 10.11405/nisshoshi.112.1474. Nihon Shokakibyo Gakkai Zasshi. 2015. PMID: 26250126 Japanese. No abstract available.
[Animal model of pancreatic cancer].
Ijichi H. Ijichi H. Nihon Rinsho. 2015 Mar;73 Suppl 3:31-6. Nihon Rinsho. 2015. PMID: 25856981 Japanese. No abstract available.
Pancreatic cancer with malignant ascites: clinical features and outcomes.
Takahara N, Isayama H, Nakai Y, Sasaki T, Saito K, Hamada T, Mizuno S, Miyabayashi K, Mohri D, Kogure H, Matsubara S, Yamamoto N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K. Takahara N, et al. Among authors: ijichi h. Pancreas. 2015 Apr;44(3):380-5. doi: 10.1097/MPA.0000000000000290. Pancreas. 2015. PMID: 25636085
The inhibition of renin-angiotensin system in advanced pancreatic cancer: an exploratory analysis in 349 patients.
Nakai Y, Isayama H, Sasaki T, Takahara N, Saito K, Ishigaki K, Hamada T, Mizuno S, Miyabayashi K, Yamamoto K, Mohri D, Kogure H, Yamamoto N, Ijichi H, Tateishi K, Tada M, Koike K. Nakai Y, et al. Among authors: ijichi h. J Cancer Res Clin Oncol. 2015 May;141(5):933-9. doi: 10.1007/s00432-014-1873-2. Epub 2014 Nov 15. J Cancer Res Clin Oncol. 2015. PMID: 25398651
A phase I trial of gemcitabine, S-1 and LV combination (GSL) therapy in advanced pancreatic cancer.
Nakai Y, Isayama H, Saito K, Sasaki T, Takahara N, Hamada T, Mizuno S, Miyabayashi K, Yamamoto K, Mohri D, Kogure H, Yamamoto N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K. Nakai Y, et al. Among authors: ijichi h. Cancer Chemother Pharmacol. 2014 Nov;74(5):911-5. doi: 10.1007/s00280-014-2563-0. Epub 2014 Aug 21. Cancer Chemother Pharmacol. 2014. PMID: 25143299 Clinical Trial.
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