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Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro.
Hagiya Y, Endo Y, Yonemura Y, Takahashi K, Ishizuka M, Abe F, Tanaka T, Okura I, Nakajima M, Ishikawa T, Ogura S. Hagiya Y, et al. Among authors: takahashi k. Photodiagnosis Photodyn Ther. 2012 Sep;9(3):204-14. doi: 10.1016/j.pdpdt.2011.12.004. Epub 2012 Jan 4. Photodiagnosis Photodyn Ther. 2012. PMID: 22959800
Fluorescent detection of peritoneal metastasis in human colorectal cancer using 5-aminolevulinic acid.
Kondo Y, Murayama Y, Konishi H, Morimura R, Komatsu S, Shiozaki A, Kuriu Y, Ikoma H, Kubota T, Nakanishi M, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Takahashi K, Inoue K, Nakajima M, Otsuji E. Kondo Y, et al. Among authors: takahashi k. Int J Oncol. 2014 Jul;45(1):41-6. doi: 10.3892/ijo.2014.2417. Epub 2014 May 6. Int J Oncol. 2014. PMID: 24821500 Free PMC article.
Efficacy of 5-Aminolevulinic Acid in Photodynamic Detection and Photodynamic Therapy in Veterinary Medicine.
Osaki T, Yokoe I, Sunden Y, Ota U, Ichikawa T, Imazato H, Ishii T, Takahashi K, Ishizuka M, Tanaka T, Li L, Yamashita M, Murahata Y, Tsuka T, Azuma K, Ito N, Imagawa T, Okamoto Y. Osaki T, et al. Among authors: takahashi k. Cancers (Basel). 2019 Apr 7;11(4):495. doi: 10.3390/cancers11040495. Cancers (Basel). 2019. PMID: 30959982 Free PMC article.
5-aminolevulinic acid-mediated photodynamic diagnosis using fluorescence ureterorenoscopy for urinary upper tract urothelial carcinoma ∼Preliminary prospective single centre trial∼.
Fukuhara H, Kurabayashi A, Furihata M, Setuda S, Takahashi K, Murakami K, Tanaka T, Inoue K. Fukuhara H, et al. Among authors: takahashi k. Photodiagnosis Photodyn Ther. 2020 Mar;29:101617. doi: 10.1016/j.pdpdt.2019.101617. Epub 2019 Dec 16. Photodiagnosis Photodyn Ther. 2020. PMID: 31857216 Free article.
Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride.
Osaki T, Gonda K, Murahata Y, Sunden Y, Amaha T, Kunisue N, Takahashi K, Ishizuka M, Tanaka T, Li L, Yokoe I, Yamashita M, Azuma K, Tsuka T, Ito N, Imagawa T, Okamoto Y. Osaki T, et al. Among authors: takahashi k. JFMS Open Rep. 2020 Mar 13;6(1):2055116920907429. doi: 10.1177/2055116920907429. eCollection 2020 Jan-Jun. JFMS Open Rep. 2020. PMID: 32206327 Free PMC article.
5-Aminolevulinic acid/sodium ferrous citrate enhanced the antitumor effects of programmed cell death-ligand 1 blockade by regulation of exhausted T cell metabolism in a melanoma model.
Hu X, Que W, Hirano H, Wang Z, Nozawa N, Ishii T, Ishizuka M, Ito H, Takahashi K, Nakajima M, Tanaka T, Zhu P, Guo WZ, Li XK. Hu X, et al. Among authors: takahashi k. Cancer Sci. 2021 Jul;112(7):2652-2663. doi: 10.1111/cas.14930. Epub 2021 May 22. Cancer Sci. 2021. PMID: 33934440 Free PMC article.
In vitro evaluation of the efficacy of photodynamic therapy using 5-ALA on homologous feline mammary tumors in 2D and 3D culture conditions and a mouse subcutaneous model with 3D cultured cells.
Lin S, Ota U, Imazato H, Takahashi K, Ishizuka M, Osaki T. Lin S, et al. Among authors: takahashi k. Photodiagnosis Photodyn Ther. 2024 Feb;45:103993. doi: 10.1016/j.pdpdt.2024.103993. Epub 2024 Jan 26. Photodiagnosis Photodyn Ther. 2024. PMID: 38280675 Free article.
5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice.
Saitoh S, Okano S, Nohara H, Nakano H, Shirasawa N, Naito A, Yamamoto M, Kelly VP, Takahashi K, Tanaka T, Nakajima M, Nakajima O. Saitoh S, et al. Among authors: takahashi k. PLoS One. 2018 Jan 24;13(1):e0189593. doi: 10.1371/journal.pone.0189593. eCollection 2018. PLoS One. 2018. PMID: 29364890 Free PMC article.
Access to a novel near-infrared photodynamic therapy through the combined use of 5-aminolevulinic acid and lanthanide nanoparticles.
Shimoyama A, Watase H, Liu Y, Ogura S, Hagiya Y, Takahashi K, Inoue K, Tanaka T, Murayama Y, Otsuji E, Ohkubo A, Yuasa H. Shimoyama A, et al. Among authors: takahashi k. Photodiagnosis Photodyn Ther. 2013 Dec;10(4):607-14. doi: 10.1016/j.pdpdt.2013.07.005. Epub 2013 Aug 9. Photodiagnosis Photodyn Ther. 2013. PMID: 24284118
Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia.
Fujiwara T, Okamoto K, Niikuni R, Takahashi K, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Nakamura Y, Nakajima M, Tanaka T, Harigae H. Fujiwara T, et al. Among authors: takahashi k. Biochem Biophys Res Commun. 2014 Nov 7;454(1):102-8. doi: 10.1016/j.bbrc.2014.10.050. Epub 2014 Oct 18. Biochem Biophys Res Commun. 2014. PMID: 25450364
Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women.
Masuki S, Morita A, Kamijo Y, Ikegawa S, Kataoka Y, Ogawa Y, Sumiyoshi E, Takahashi K, Tanaka T, Nakajima M, Nose H. Masuki S, et al. Among authors: takahashi k. J Appl Physiol (1985). 2016 Jan 1;120(1):87-96. doi: 10.1152/japplphysiol.00582.2015. Epub 2015 Oct 29. J Appl Physiol (1985). 2016. PMID: 26514619 Free PMC article. Clinical Trial.
5-Aminolevulinic acid with sodium ferrous citrate induces autophagy and protects cardiomyocytes from hypoxia-induced cellular injury through MAPK-Nrf-2-HO-1 signaling cascade.
Zhao M, Zhu P, Fujino M, Nishio Y, Chen J, Ito H, Takahashi K, Nakajima M, Tanaka T, Zhao L, Zhuang J, Li XK. Zhao M, et al. Among authors: takahashi k. Biochem Biophys Res Commun. 2016 Oct 28;479(4):663-669. doi: 10.1016/j.bbrc.2016.09.156. Epub 2016 Sep 29. Biochem Biophys Res Commun. 2016. PMID: 27693692
5-aminolaevulinic acid (ALA), enhances heme oxygenase (HO)-1 expression and attenuates tubulointerstitial fibrosis and renal apoptosis in chronic cyclosporine nephropathy.
Liu C, Zhu P, Fujino M, Isaka Y, Ito H, Takahashi K, Nakajima M, Tanaka T, Zhuang J, Li XK. Liu C, et al. Among authors: takahashi k. Biochem Biophys Res Commun. 2019 Jan 8;508(2):583-589. doi: 10.1016/j.bbrc.2018.11.175. Epub 2018 Dec 2. Biochem Biophys Res Commun. 2019. PMID: 30514440
Effects of 5-aminolevulinic acid and sodium ferrous citrate on fibroblasts from individuals with mitochondrial diseases.
Shimura M, Nozawa N, Ogawa-Tominaga M, Fushimi T, Tajika M, Ichimoto K, Matsunaga A, Tsuruoka T, Kishita Y, Ishii T, Takahashi K, Tanaka T, Nakajima M, Okazaki Y, Ohtake A, Murayama K. Shimura M, et al. Among authors: takahashi k. Sci Rep. 2019 Jul 22;9(1):10549. doi: 10.1038/s41598-019-46772-x. Sci Rep. 2019. PMID: 31332208 Free PMC article.
5-Aminolevulinic acid combined with sodium ferrous citrate (5-ALA/SFC) ameliorated liver injury in a murine acute graft-versus-host disease model by reducing inflammation responses through PGC1-α activation.
Wang Z, Ma K, Liu C, Hu X, Que W, Ito H, Takahashi K, Nakajima M, Tanaka T, Ren K, Guo WZ, Yi SQ, Li XK. Wang Z, et al. Among authors: takahashi k. Drug Discov Ther. 2021 Jan 23;14(6):304-312. doi: 10.5582/ddt.2020.03112. Epub 2020 Dec 30. Drug Discov Ther. 2021. PMID: 33390570 Free article.
Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.
van Wijk K, Akabane T, Kimura T, Saitoh S, Okano S, Kelly VP, Takagi M, Kodama K, Takahashi K, Tanaka T, Nakajima M, Nakajima O. van Wijk K, et al. Among authors: takahashi k. Arch Biochem Biophys. 2021 Jan 15;697:108721. doi: 10.1016/j.abb.2020.108721. Epub 2020 Dec 8. Arch Biochem Biophys. 2021. PMID: 33307066 Free article.
Characteristics and outcomes of out-of-hospital cardiac arrest in a hilly area: Utstein Registry data from the Nagasaki Medical Region, Japan.
Zmushka V, Tajima G, Iyama K, Hayakawa K, Yamashita K, Inokuma T, Izumino H, Otaguro T, Uemura E, Ueki T, Murahashi S, Yamano S, Takahashi K, Aoki Y, Tachikawa A, Tasaki O. Zmushka V, et al. Among authors: takahashi k. Acute Med Surg. 2024 May 15;11(1):e966. doi: 10.1002/ams2.966. eCollection 2024 Jan-Dec. Acute Med Surg. 2024. PMID: 38756720 Free PMC article.
A method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target.
Nakamura S, Takemori M, Nakaichi T, Shuto Y, Kashihara T, Iijima K, Chiba T, Nakayama H, Urago Y, Nishina S, Kobayashi Y, Kishida H, Imamichi S, Takahashi K, Masutani M, Okamoto H, Nishio T, Itami J, Igaki H. Nakamura S, et al. Among authors: takahashi k. Sci Rep. 2024 May 16;14(1):11253. doi: 10.1038/s41598-024-62060-9. Sci Rep. 2024. PMID: 38755333 Free PMC article.
Recent advancements in image-enhanced endoscopy in the pancreatobiliary field.
Toyonaga H, Hayashi T, Hama K, Ando R, Ishii T, Yoshida K, Kin T, Motoya M, Takahashi K, Katanuma A. Toyonaga H, et al. Among authors: takahashi k. DEN Open. 2024 May 14;5(1):e382. doi: 10.1002/deo2.382. eCollection 2025 Apr. DEN Open. 2024. PMID: 38746904 Free PMC article. Review.
Amyand's Hernia diagnosed preoperatively via a CT scan: A case report.
Kawata A, Hasegawa M, Morishita S, Fujii T, Hagiwara O, Joki N, Takahashi K, Yokouchi Y, Gomi T. Kawata A, et al. Among authors: takahashi k. Radiol Case Rep. 2024 May 3;19(8):2923-2928. doi: 10.1016/j.radcr.2024.04.031. eCollection 2024 Aug. Radiol Case Rep. 2024. PMID: 38737171 Free PMC article.
Programmed Death Ligand 1 Expression in Circulating Tumor Cells as a Predictor and Monitor of Response to Atezolizumab plus Bevacizumab Treatment in Patients with Hepatocellular Carcinoma.
Nosaka T, Murata Y, Akazawa Y, Tanaka T, Takahashi K, Naito T, Matsuda H, Ohtani M, Imamura Y, Nakamoto Y. Nosaka T, et al. Among authors: takahashi k. Cancers (Basel). 2024 May 6;16(9):1785. doi: 10.3390/cancers16091785. Cancers (Basel). 2024. PMID: 38730737 Free PMC article.
Segmentation and Volume Estimation of the Habenula Using Deep Learning in Patients With Depression.
Kyuragi Y, Oishi N, Hatakoshi M, Hirano J, Noda T, Yoshihara Y, Ito Y, Igarashi H, Miyata J, Takahashi K, Kamiya K, Matsumoto J, Okada T, Fushimi Y, Nakagome K, Mimura M, Murai T, Suwa T. Kyuragi Y, et al. Among authors: takahashi k. Biol Psychiatry Glob Open Sci. 2024 Apr 3;4(4):100314. doi: 10.1016/j.bpsgos.2024.100314. eCollection 2024 Jul. Biol Psychiatry Glob Open Sci. 2024. PMID: 38726037 Free PMC article.
Comparative studies of hair shaft components between healthy and diseased donors.
Ota A, Kitamura H, Sugimoto K, Ogawa M, Dohmae N, Okuno H, Takahashi K, Ikeda K, Tomita T, Matsuoka N, Matsuishi K, Inokuma T, Nagano T, Takeo M, Tsuji T. Ota A, et al. Among authors: takahashi k. PLoS One. 2024 May 8;19(5):e0301092. doi: 10.1371/journal.pone.0301092. eCollection 2024. PLoS One. 2024. PMID: 38718028 Free PMC article.
Large-Scale Whole-Genome Analysis of HTLV-1-Associated Myelopathy Identified Hereditary Spastic Paraplegias.
Takao N, Yagishita N, Araya N, Aratani S, Yamauchi J, Takahashi K, Kunitomo Y, Sato T, Nakamori M, Kawai Y, Omae Y, Tokunaga K, Matsuda F, Mitsuhashi S, Yamano Y. Takao N, et al. Among authors: takahashi k. Neurol Genet. 2024 Jan 29;10(1):e200108. doi: 10.1212/NXG.0000000000200108. eCollection 2024 Feb. Neurol Genet. 2024. PMID: 38716326 Free PMC article.
Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration.
Iguchi Y, Fukabori R, Kato S, Takahashi K, Eifuku S, Maejima Y, Shimomura K, Mizuma H, Mawatari A, Doi H, Cui Y, Onoe H, Hikishima K, Osanai M, Nishijo T, Momiyama T, Benton R, Kobayashi K. Iguchi Y, et al. Among authors: takahashi k. Commun Biol. 2024 May 7;7(1):547. doi: 10.1038/s42003-024-06223-4. Commun Biol. 2024. PMID: 38714803 Free PMC article.
Imaging demyelinated axons after spinal cord injuries with PET tracer [ 18 F]3F4AP.
Ramos-Torres KM, Conti S, Zhou YP, Tiss A, Caravagna C, Takahashi K, He M, Wilks MQ, Eckl S, Sun Y, Biundo J, Gong K, He Z, Linnman C, Brugarolas P. Ramos-Torres KM, et al. Among authors: takahashi k. bioRxiv [Preprint]. 2024 May 17:2024.04.24.590984. doi: 10.1101/2024.04.24.590984. bioRxiv. 2024. PMID: 38712041 Free PMC article. Preprint.
Acute exacerbation predicting poor outcomes in idiopathic interstitial pneumonia and advanced lung cancer patients undergoing cytotoxic chemotherapy.
Miyamoto A, Michimae H, Nakahara Y, Akagawa S, Nakagawa K, Minegishi Y, Ogura T, Hontsu S, Date H, Takahashi K, Homma S, Kishi K; Investigators Group for Lung Cancer and IIP. Miyamoto A, et al. Among authors: takahashi k. Sci Rep. 2024 May 3;14(1):10162. doi: 10.1038/s41598-024-60833-w. Sci Rep. 2024. PMID: 38702426 Free PMC article.
Improvement of β-Cell Function After Switching From DPP-4 Inhibitors to Oral Semaglutide: SWITCH-SEMA2 Post Hoc Analysis.
Nomoto H, Furusawa S, Yokoyama H, Suzuki Y, Izumihara R, Oe Y, Takahashi K, Miya A, Kameda H, Cho KY, Takeuchi J, Kurihara Y, Nakamura A, Atsumi T. Nomoto H, et al. Among authors: takahashi k. J Clin Endocrinol Metab. 2024 May 2:dgae213. doi: 10.1210/clinem/dgae213. Online ahead of print. J Clin Endocrinol Metab. 2024. PMID: 38695547
Outcomes and genetic dynamics of acute myeloid leukemia at first relapse.
Bataller A, Kantarjian H, Bazinet A, Kadia T, Daver N, DiNardo CD, Borthakur G, Loghavi S, Patel K, Tang G, Sasaki K, Short NJ, Yilmaz M, Issa GC, Alvarado Y, Montalban-Bravo G, Maiti A, Abbas HA, Takahashi K, Pierce S, Jabbour E, Garcia-Manero G, Ravandi F. Bataller A, et al. Among authors: takahashi k. Haematologica. 2024 May 2. doi: 10.3324/haematol.2024.285057. Online ahead of print. Haematologica. 2024. PMID: 38695144 Free article.
Clinical Benefits of Reducing Dead Space Using a Closed Suction Drain and Subcutaneous Large-bite Buried Suture Technique to Prevent Superficial Surgical-site Infections Following Primary Closure of a Diverting Stoma.
Ohara Y, Owada Y, Kim J, Moue S, Akashi Y, Ogawa K, Takahashi K, Shimomura O, Furuya K, Hashimoto S, Enomoto T, Oda T. Ohara Y, et al. Among authors: takahashi k. J Anus Rectum Colon. 2024 Apr 25;8(2):70-77. doi: 10.23922/jarc.2023-047. eCollection 2024. J Anus Rectum Colon. 2024. PMID: 38689778 Free PMC article.
Optimization of Absolute Coronary Blood Flow Measurements to Assess Microvascular Function: In Vivo Validation of Hyperemia and Higher Infusion Speeds.
Minten L, Bennett J, McCutcheon K, Oosterlinck W, Algoet M, Otsuki H, Takahashi K, Fearon WF, Dubois C. Minten L, et al. Among authors: takahashi k. Circ Cardiovasc Interv. 2024 Apr 29:e013860. doi: 10.1161/CIRCINTERVENTIONS.123.013860. Online ahead of print. Circ Cardiovasc Interv. 2024. PMID: 38682331
The real-world data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study.
Sato S, Ssuzuki T, Chinen T, Yamaguchi H, Suzuki Y, Hokamura N, Saze Z, Kono K, Takahashi K, Yano F, Kunisaki C, Kosaka T, Endo I, Ichikawa Y, Miyawaki Y, Sato H, Shimada H. Sato S, et al. Among authors: takahashi k. Int J Clin Oncol. 2024 Apr 28. doi: 10.1007/s10147-024-02532-0. Online ahead of print. Int J Clin Oncol. 2024. PMID: 38679627
Comparison of diagnostic accuracy between linked color imaging and autofluorescence imaging in patients with ulcerative colitis: A prospective observational study.
Sugiyama Y, Takahashi K, Sasaki T, Ueno N, Watanabe H, Iribe K, Sekiguchi S, Tachibana S, Kobayashi Y, Ando K, Kashima S, Moriichi K, Tanabe H, Yuzawa S, Fujiya M. Sugiyama Y, et al. Among authors: takahashi k. J Gastroenterol Hepatol. 2024 Apr 27. doi: 10.1111/jgh.16586. Online ahead of print. J Gastroenterol Hepatol. 2024. PMID: 38676457
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
Mizuguchi M, Nakagawa Y, Yokoyama T, Okada T, Fujii K, Takahashi K, Luan NNT, Nabeshima Y, Kanamitsu K, Nakagawa S, Yamakawa S, Ueda M, Ando Y, Toyooka N. Mizuguchi M, et al. Among authors: takahashi k. J Med Chem. 2024 Apr 26;67(9):6987-7005. doi: 10.1021/acs.jmedchem.3c02286. Online ahead of print. J Med Chem. 2024. PMID: 38670538 Free PMC article.
Global trends and scenarios for terrestrial biodiversity and ecosystem services from 1900 to 2050.
Pereira HM, Martins IS, Rosa IMD, Kim H, Leadley P, Popp A, van Vuuren DP, Hurtt G, Quoss L, Arneth A, Baisero D, Bakkenes M, Chaplin-Kramer R, Chini L, Di Marco M, Ferrier S, Fujimori S, Guerra CA, Harfoot M, Harwood TD, Hasegawa T, Haverd V, Havlík P, Hellweg S, Hilbers JP, Hill SLL, Hirata A, Hoskins AJ, Humpenöder F, Janse JH, Jetz W, Johnson JA, Krause A, Leclère D, Matsui T, Meijer JR, Merow C, Obersteiner M, Ohashi H, De Palma A, Poulter B, Purvis A, Quesada B, Rondinini C, Schipper AM, Settele J, Sharp R, Stehfest E, Strassburg BBN, Takahashi K, Talluto MV, Thuiller W, Titeux N, Visconti P, Ware C, Wolf F, Alkemade R. Pereira HM, et al. Among authors: takahashi k. Science. 2024 Apr 26;384(6694):458-465. doi: 10.1126/science.adn3441. Epub 2024 Apr 25. Science. 2024. PMID: 38662818
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