Blobel GA - Search Results

1

HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation.

Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA. Peslak SA, et al. Among authors: blobel ga. Blood Adv. 2020 Sep 22;4(18):4560-4572. doi: 10.1182/bloodadvances.2020002475. Blood Adv. 2020. PMID: 32956454 Free PMC article.

2

Global regulation of erythroid gene expression by transcription factor GATA-1.

Welch JJ, Watts JA, Vakoc CR, Yao Y, Wang H, Hardison RC, Blobel GA, Chodosh LA, Weiss MJ. Welch JJ, et al. Among authors: blobel ga. Blood. 2004 Nov 15;104(10):3136-47. doi: 10.1182/blood-2004-04-1603. Epub 2004 Aug 5. Blood. 2004. PMID: 15297311 Free article.

3

Acetylation of GATA-1 is required for chromatin occupancy.

Lamonica JM, Vakoc CR, Blobel GA. Lamonica JM, et al. Among authors: blobel ga. Blood. 2006 Dec 1;108(12):3736-8. doi: 10.1182/blood-2006-07-032847. Epub 2006 Aug 3. Blood. 2006. PMID: 16888089 Free PMC article.

4

SCL and associated proteins distinguish active from repressive GATA transcription factor complexes.

Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison RC, Blobel GA. Tripic T, et al. Among authors: blobel ga. Blood. 2009 Mar 5;113(10):2191-201. doi: 10.1182/blood-2008-07-169417. Epub 2008 Nov 14. Blood. 2009. PMID: 19011221 Free PMC article.

5

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.

Chou ST, Khandros E, Bailey LC, Nichols KE, Vakoc CR, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ. Chou ST, et al. Among authors: blobel ga. Blood. 2009 Jul 30;114(5):983-94. doi: 10.1182/blood-2009-03-207944. Epub 2009 Jun 2. Blood. 2009. PMID: 19491391 Free PMC article.

6

Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression.

Cheng Y, Wu W, Kumar SA, Yu D, Deng W, Tripic T, King DC, Chen KB, Zhang Y, Drautz D, Giardine B, Schuster SC, Miller W, Chiaromonte F, Zhang Y, Blobel GA, Weiss MJ, Hardison RC. Cheng Y, et al. Among authors: blobel ga. Genome Res. 2009 Dec;19(12):2172-84. doi: 10.1101/gr.098921.109. Epub 2009 Nov 3. Genome Res. 2009. PMID: 19887574 Free PMC article.

7

FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment.

Gregory GD, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel GA. Gregory GD, et al. Among authors: blobel ga. Blood. 2010 Mar 18;115(11):2156-66. doi: 10.1182/blood-2009-10-251280. Epub 2010 Jan 11. Blood. 2010. PMID: 20065294 Free PMC article.

8

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.

Lamonica JM, Deng W, Kadauke S, Campbell AE, Gamsjaeger R, Wang H, Cheng Y, Billin AN, Hardison RC, Mackay JP, Blobel GA. Lamonica JM, et al. Among authors: blobel ga. Proc Natl Acad Sci U S A. 2011 May 31;108(22):E159-68. doi: 10.1073/pnas.1102140108. Epub 2011 May 2. Proc Natl Acad Sci U S A. 2011. PMID: 21536911 Free PMC article.

9

Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration.

Wu W, Cheng Y, Keller CA, Ernst J, Kumar SA, Mishra T, Morrissey C, Dorman CM, Chen KB, Drautz D, Giardine B, Shibata Y, Song L, Pimkin M, Crawford GE, Furey TS, Kellis M, Miller W, Taylor J, Schuster SC, Zhang Y, Chiaromonte F, Blobel GA, Weiss MJ, Hardison RC. Wu W, et al. Among authors: blobel ga. Genome Res. 2011 Oct;21(10):1659-71. doi: 10.1101/gr.125088.111. Epub 2011 Jul 27. Genome Res. 2011. PMID: 21795386 Free PMC article.

10

Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1.

Kadauke S, Udugama MI, Pawlicki JM, Achtman JC, Jain DP, Cheng Y, Hardison RC, Blobel GA. Kadauke S, et al. Among authors: blobel ga. Cell. 2012 Aug 17;150(4):725-37. doi: 10.1016/j.cell.2012.06.038. Cell. 2012. PMID: 22901805 Free PMC article.

11

Analysis of disease-causing GATA1 mutations in murine gene complementation systems.

Campbell AE, Wilkinson-White L, Mackay JP, Matthews JM, Blobel GA. Campbell AE, et al. Among authors: blobel ga. Blood. 2013 Jun 27;121(26):5218-27. doi: 10.1182/blood-2013-03-488080. Epub 2013 May 23. Blood. 2013. PMID: 23704091 Free PMC article.

12

A cluster to remember.

Blobel GA, Hardison RC. Blobel GA, et al. Cell. 2013 Aug 15;154(4):718-20. doi: 10.1016/j.cell.2013.07.041. Cell. 2013. PMID: 23953105 Free PMC article.

13

Genetics. GWAS to therapy by genome edits?

Hardison RC, Blobel GA. Hardison RC, et al. Among authors: blobel ga. Science. 2013 Oct 11;342(6155):206-7. doi: 10.1126/science.1245813. Science. 2013. PMID: 24115432 Free PMC article. No abstract available.

14

Function of GATA factors in the adult mouse liver.

Zheng R, Rebolledo-Jaramillo B, Zong Y, Wang L, Russo P, Hancock W, Stanger BZ, Hardison RC, Blobel GA. Zheng R, et al. Among authors: blobel ga. PLoS One. 2013 Dec 18;8(12):e83723. doi: 10.1371/journal.pone.0083723. eCollection 2013. PLoS One. 2013. PMID: 24367609 Free PMC article.

15

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.

Wu W, Morrissey CS, Keller CA, Mishra T, Pimkin M, Blobel GA, Weiss MJ, Hardison RC. Wu W, et al. Among authors: blobel ga. Genome Res. 2014 Dec;24(12):1945-62. doi: 10.1101/gr.164830.113. Epub 2014 Oct 15. Genome Res. 2014. PMID: 25319994 Free PMC article.

16

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis.

Pimkin M, Kossenkov AV, Mishra T, Morrissey CS, Wu W, Keller CA, Blobel GA, Lee D, Beer MA, Hardison RC, Weiss MJ. Pimkin M, et al. Among authors: blobel ga. Genome Res. 2014 Dec;24(12):1932-44. doi: 10.1101/gr.164178.113. Epub 2014 Oct 15. Genome Res. 2014. PMID: 25319996 Free PMC article.

17

Genome accessibility is widely preserved and locally modulated during mitosis.

Hsiung CC, Morrissey CS, Udugama M, Frank CL, Keller CA, Baek S, Giardine B, Crawford GE, Sung MH, Hardison RC, Blobel GA. Hsiung CC, et al. Among authors: blobel ga. Genome Res. 2015 Feb;25(2):213-25. doi: 10.1101/gr.180646.114. Epub 2014 Nov 4. Genome Res. 2015. PMID: 25373146 Free PMC article.

18

A comparative encyclopedia of DNA elements in the mouse genome.

Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P,… See abstract for full author list ➔ Yue F, et al. Among authors: blobel ga. Nature. 2014 Nov 20;515(7527):355-64. doi: 10.1038/nature13992. Nature. 2014. PMID: 25409824 Free PMC article.

19

Principles of regulatory information conservation between mouse and human.

Cheng Y, Ma Z, Kim BH, Wu W, Cayting P, Boyle AP, Sundaram V, Xing X, Dogan N, Li J, Euskirchen G, Lin S, Lin Y, Visel A, Kawli T, Yang X, Patacsil D, Keller CA, Giardine B; mouse ENCODE Consortium; Kundaje A, Wang T, Pennacchio LA, Weng Z, Hardison RC, Snyder MP. Cheng Y, et al. Nature. 2014 Nov 20;515(7527):371-375. doi: 10.1038/nature13985. Nature. 2014. PMID: 25409826 Free PMC article.

20

Keeping fetal hemoglobin in the loop.

Grevet JD, Blobel GA. Grevet JD, et al. Among authors: blobel ga. Cell Cycle. 2014;13(20):3153-4. doi: 10.4161/15384101.2014.969995. Cell Cycle. 2014. PMID: 25485488 Free PMC article. No abstract available.

21

Functions of BET proteins in erythroid gene expression.

Stonestrom AJ, Hsu SC, Jahn KS, Huang P, Keller CA, Giardine BM, Kadauke S, Campbell AE, Evans P, Hardison RC, Blobel GA. Stonestrom AJ, et al. Among authors: blobel ga. Blood. 2015 Apr 30;125(18):2825-34. doi: 10.1182/blood-2014-10-607309. Epub 2015 Feb 18. Blood. 2015. PMID: 25696920 Free PMC article.

22

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.

Dogan N, Wu W, Morrissey CS, Chen KB, Stonestrom A, Long M, Keller CA, Cheng Y, Jain D, Visel A, Pennacchio LA, Weiss MJ, Blobel GA, Hardison RC. Dogan N, et al. Among authors: blobel ga. Epigenetics Chromatin. 2015 Apr 23;8:16. doi: 10.1186/s13072-015-0009-5. eCollection 2015. Epigenetics Chromatin. 2015. PMID: 25984238 Free PMC article.

23

Dynamic enhancer-gene body contacts during transcription elongation.

Lee K, Hsiung CC, Huang P, Raj A, Blobel GA. Lee K, et al. Among authors: blobel ga. Genes Dev. 2015 Oct 1;29(19):1992-7. doi: 10.1101/gad.255265.114. Genes Dev. 2015. PMID: 26443845 Free PMC article.

24

Unlinking an lncRNA from Its Associated cis Element.

Paralkar VR, Taborda CC, Huang P, Yao Y, Kossenkov AV, Prasad R, Luan J, Davies JO, Hughes JR, Hardison RC, Blobel GA, Weiss MJ. Paralkar VR, et al. Among authors: blobel ga. Mol Cell. 2016 Apr 7;62(1):104-10. doi: 10.1016/j.molcel.2016.02.029. Epub 2016 Mar 31. Mol Cell. 2016. PMID: 27041223 Free PMC article.

25

A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.

Hsiung CC, Bartman CR, Huang P, Ginart P, Stonestrom AJ, Keller CA, Face C, Jahn KS, Evans P, Sankaranarayanan L, Giardine B, Hardison RC, Raj A, Blobel GA. Hsiung CC, et al. Among authors: blobel ga. Genes Dev. 2016 Jun 15;30(12):1423-39. doi: 10.1101/gad.280859.116. Genes Dev. 2016. PMID: 27340175 Free PMC article.

26

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.

Breda L, Motta I, Lourenco S, Gemmo C, Deng W, Rupon JW, Abdulmalik OY, Manwani D, Blobel GA, Rivella S. Breda L, et al. Among authors: blobel ga. Blood. 2016 Aug 25;128(8):1139-43. doi: 10.1182/blood-2016-01-691089. Epub 2016 Jul 12. Blood. 2016. PMID: 27405777 Free PMC article.

27

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.

Traxler EA, Yao Y, Wang YD, Woodard KJ, Kurita R, Nakamura Y, Hughes JR, Hardison RC, Blobel GA, Li C, Weiss MJ. Traxler EA, et al. Among authors: blobel ga. Nat Med. 2016 Sep;22(9):987-90. doi: 10.1038/nm.4170. Epub 2016 Aug 15. Nat Med. 2016. PMID: 27525524 Free PMC article.

28

The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

Xia Q, Chesi A, Manduchi E, Johnston BT, Lu S, Leonard ME, Parlin UW, Rappaport EF, Huang P, Wells AD, Blobel GA, Johnson ME, Grant SFA. Xia Q, et al. Among authors: blobel ga. Diabetologia. 2016 Nov;59(11):2360-2368. doi: 10.1007/s00125-016-4077-2. Epub 2016 Aug 18. Diabetologia. 2016. PMID: 27539148

29

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.

Hsu SC, Gilgenast TG, Bartman CR, Edwards CR, Stonestrom AJ, Huang P, Emerson DJ, Evans P, Werner MT, Keller CA, Giardine B, Hardison RC, Raj A, Phillips-Cremins JE, Blobel GA. Hsu SC, et al. Among authors: blobel ga. Mol Cell. 2017 Apr 6;66(1):102-116.e7. doi: 10.1016/j.molcel.2017.02.027. Mol Cell. 2017. PMID: 28388437 Free PMC article.

30

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.

Huang P, Keller CA, Giardine B, Grevet JD, Davies JOJ, Hughes JR, Kurita R, Nakamura Y, Hardison RC, Blobel GA. Huang P, et al. Among authors: blobel ga. Genes Dev. 2017 Aug 15;31(16):1704-1713. doi: 10.1101/gad.303461.117. Epub 2017 Sep 15. Genes Dev. 2017. PMID: 28916711 Free PMC article.

31

A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.

Gallagher MD, Posavi M, Huang P, Unger TL, Berlyand Y, Gruenewald AL, Chesi A, Manduchi E, Wells AD, Grant SFA, Blobel GA, Brown CD, Chen-Plotkin AS. Gallagher MD, et al. Among authors: blobel ga. Am J Hum Genet. 2017 Nov 2;101(5):643-663. doi: 10.1016/j.ajhg.2017.09.004. Epub 2017 Oct 19. Am J Hum Genet. 2017. PMID: 29056226 Free PMC article.

32

Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility.

Behera V, Evans P, Face CJ, Hamagami N, Sankaranarayanan L, Keller CA, Giardine B, Tan K, Hardison RC, Shi J, Blobel GA. Behera V, et al. Among authors: blobel ga. Nat Commun. 2018 Feb 22;9(1):782. doi: 10.1038/s41467-018-03082-6. Nat Commun. 2018. PMID: 29472540 Free PMC article.

33

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.

Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA. Grevet JD, et al. Among authors: blobel ga. Science. 2018 Jul 20;361(6399):285-290. doi: 10.1126/science.aao0932. Science. 2018. PMID: 30026227 Free PMC article.

34

Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation.

Bartman CR, Hamagami N, Keller CA, Giardine B, Hardison RC, Blobel GA, Raj A. Bartman CR, et al. Among authors: blobel ga. Mol Cell. 2019 Feb 7;73(3):519-532.e4. doi: 10.1016/j.molcel.2018.11.004. Epub 2018 Dec 13. Mol Cell. 2019. PMID: 30554946 Free PMC article.

35

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription.

Behera V, Stonestrom AJ, Hamagami N, Hsiung CC, Keller CA, Giardine B, Sidoli S, Yuan ZF, Bhanu NV, Werner MT, Wang H, Garcia BA, Hardison RC, Blobel GA. Behera V, et al. Among authors: blobel ga. Cell Rep. 2019 Apr 9;27(2):400-415.e5. doi: 10.1016/j.celrep.2019.03.057. Cell Rep. 2019. PMID: 30970245 Free PMC article.

36

The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells.

Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA. Lan X, et al. Among authors: blobel ga. Blood Adv. 2019 May 28;3(10):1586-1597. doi: 10.1182/bloodadvances.2019032318. Blood Adv. 2019. PMID: 31126914 Free PMC article.

37

Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells.

Hardison RC, Zhang Y, Keller CA, Xiang G, Heuston EF, An L, Lichtenberg J, Giardine BM, Bodine D, Mahony S, Li Q, Yue F, Weiss MJ, Blobel GA, Taylor J, Hughes J, Higgs DR, Göttgens B. Hardison RC, et al. Among authors: blobel ga. IUBMB Life. 2020 Jan;72(1):27-38. doi: 10.1002/iub.2195. Epub 2019 Nov 25. IUBMB Life. 2020. PMID: 31769130 Free PMC article. Review.

38

Chromatin structure dynamics during the mitosis-to-G1 phase transition.

Zhang H, Emerson DJ, Gilgenast TG, Titus KR, Lan Y, Huang P, Zhang D, Wang H, Keller CA, Giardine B, Hardison RC, Phillips-Cremins JE, Blobel GA. Zhang H, et al. Among authors: blobel ga. Nature. 2019 Dec;576(7785):158-162. doi: 10.1038/s41586-019-1778-y. Epub 2019 Nov 27. Nature. 2019. PMID: 31776509 Free PMC article.

39

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis.

Xiang G, Keller CA, Heuston E, Giardine BM, An L, Wixom AQ, Miller A, Cockburn A, Sauria MEG, Weaver K, Lichtenberg J, Göttgens B, Li Q, Bodine D, Mahony S, Taylor J, Blobel GA, Weiss MJ, Cheng Y, Yue F, Hughes J, Higgs DR, Zhang Y, Hardison RC. Xiang G, et al. Among authors: blobel ga. Genome Res. 2020 Mar;30(3):472-484. doi: 10.1101/gr.255760.119. Epub 2020 Mar 4. Genome Res. 2020. PMID: 32132109 Free PMC article.

40

Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts.

Khandros E, Huang P, Peslak SA, Sharma M, Abdulmalik O, Giardine BM, Zhang Z, Keller CA, Hardison RC, Blobel GA. Khandros E, et al. Among authors: blobel ga. Blood. 2020 May 28;135(22):1957-1968. doi: 10.1182/blood.2020005058. Blood. 2020. PMID: 32268371 Free PMC article.

41

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression.

Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA. Huang P, et al. Among authors: blobel ga. Blood. 2020 Jun 11;135(24):2121-2132. doi: 10.1182/blood.2020005301. Blood. 2020. PMID: 32299090 Free PMC article.

42

Alteration of genome folding via contact domain boundary insertion.

Zhang D, Huang P, Sharma M, Keller CA, Giardine B, Zhang H, Gilgenast TG, Phillips-Cremins JE, Hardison RC, Blobel GA. Zhang D, et al. Among authors: blobel ga. Nat Genet. 2020 Oct;52(10):1076-1087. doi: 10.1038/s41588-020-0680-8. Epub 2020 Aug 31. Nat Genet. 2020. PMID: 32868908 Free PMC article.

43

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.

Lan X, Ren R, Feng R, Ly LC, Lan Y, Zhang Z, Aboreden N, Qin K, Horton JR, Grevet JD, Mayuranathan T, Abdulmalik O, Keller CA, Giardine B, Hardison RC, Crossley M, Weiss MJ, Cheng X, Shi J, Blobel GA. Lan X, et al. Among authors: blobel ga. Mol Cell. 2021 Jan 21;81(2):239-254.e8. doi: 10.1016/j.molcel.2020.11.006. Epub 2020 Dec 9. Mol Cell. 2021. PMID: 33301730 Free PMC article.

44

Distinct properties and functions of CTCF revealed by a rapidly inducible degron system.

Luan J, Xiang G, Gómez-García PA, Tome JM, Zhang Z, Vermunt MW, Zhang H, Huang A, Keller CA, Giardine BM, Zhang Y, Lan Y, Lis JT, Lakadamyali M, Hardison RC, Blobel GA. Luan J, et al. Among authors: blobel ga. Cell Rep. 2021 Feb 23;34(8):108783. doi: 10.1016/j.celrep.2021.108783. Cell Rep. 2021. PMID: 33626344 Free PMC article.

45

Heterogeneity of fetal hemoglobin production in adult red blood cells.

Khandros E, Blobel GA. Khandros E, et al. Among authors: blobel ga. Curr Opin Hematol. 2021 May 1;28(3):164-170. doi: 10.1097/MOH.0000000000000640. Curr Opin Hematol. 2021. PMID: 33631783 Free PMC article. Review.

46

Effects of sheared chromatin length on ChIP-seq quality and sensitivity.

Keller CA, Wixom AQ, Heuston EF, Giardine B, Hsiung CC, Long MR, Miller A, Anderson SM, Cockburn A, Blobel GA, Bodine DM, Hardison RC. Keller CA, et al. Among authors: blobel ga. G3 (Bethesda). 2021 Jun 17;11(6):jkab101. doi: 10.1093/g3journal/jkab101. G3 (Bethesda). 2021. PMID: 33788948 Free PMC article.

47

ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.

Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Cao Z, et al. Among authors: blobel ga. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. Mol Cell. 2021. PMID: 34358447 Free PMC article.

48

CTCF and transcription influence chromatin structure re-configuration after mitosis.

Zhang H, Lam J, Zhang D, Lan Y, Vermunt MW, Keller CA, Giardine B, Hardison RC, Blobel GA. Zhang H, et al. Among authors: blobel ga. Nat Commun. 2021 Aug 27;12(1):5157. doi: 10.1038/s41467-021-25418-5. Nat Commun. 2021. PMID: 34453048 Free PMC article.

49

Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression.

Topfer SK, Feng R, Huang P, Ly LC, Martyn GE, Blobel GA, Weiss MJ, Quinlan KGR, Crossley M. Topfer SK, et al. Among authors: blobel ga. Blood. 2022 Apr 7;139(14):2107-2118. doi: 10.1182/blood.2021014205. Blood. 2022. PMID: 35090172 Free PMC article.

50

Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.

Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA. Qin K, et al. Among authors: blobel ga. Nat Genet. 2022 Jun;54(6):874-884. doi: 10.1038/s41588-022-01076-1. Epub 2022 May 26. Nat Genet. 2022. PMID: 35618846 Free PMC article.

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