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Page 1
One-Year Pharmacovigilance Update of Brodalumab.
Lebwohl M, Leonardi C, Wu JJ, Yamauchi P, Rawnsley N, Merchant M, Alexander B, Jacobson A. Lebwohl M, et al. Among authors: merchant m. J Drugs Dermatol. 2020 Aug 1;19(8):807-808. doi: 10.36849/JDD.2020.5138. J Drugs Dermatol. 2020. PMID: 32845586 No abstract available.
Two-Year US Pharmacovigilance Report on Brodalumab.
Lebwohl M, Leonardi C, Wu JJ, Armstrong A, Rawnsley N, Merchant M, Alexander B, Jacobson A. Lebwohl M, et al. Among authors: merchant m. Dermatol Ther (Heidelb). 2021 Feb;11(1):173-180. doi: 10.1007/s13555-020-00472-x. Epub 2020 Dec 18. Dermatol Ther (Heidelb). 2021. PMID: 33337520 Free PMC article.
First in vitro measurement of VHEE relative biological effectiveness (RBE) in lung and prostate cancer cells using the ARES linac at DESY.
Wanstall HC, Burkart F, Dinter H, Kellermeier M, Kuropka W, Mayet F, Vinatier T, Santina E, Chadwick AL, Merchant MJ, Henthorn NT, Köpke M, Stacey B, Jaster-Merz S, Jones RM. Wanstall HC, et al. Among authors: merchant mj. Sci Rep. 2024 May 13;14(1):10957. doi: 10.1038/s41598-024-60585-7. Sci Rep. 2024. PMID: 38740830 Free PMC article.
Multiomics Analysis of PCB126's Effect on a Mouse Chronic-Binge Alcohol Feeding Model.
Gripshover TC, Wahlang B, Head KZ, Luo J, Bolatimi OE, Smith ML, Rouchka EC, Chariker JH, Xu J, Cai L, Cummins TD, Merchant ML, Zheng H, Kong M, Cave MC. Gripshover TC, et al. Among authors: merchant ml. Environ Health Perspect. 2024 Apr;132(4):47007. doi: 10.1289/EHP14132. Epub 2024 Apr 15. Environ Health Perspect. 2024. PMID: 38619879 Free PMC article.
Primary results and characterization of patients with exceptional outcomes in a phase 1b study combining PARP and MEK inhibition, with or without anti-PD-L1, for BRCA wild-type, platinum-sensitive, recurrent ovarian cancer.
Mutch D, Voulgari A, Chen XM, Bradley WH, Oaknin A, Perez Fidalgo JA, Montosa FG, Herraez AC, Holloway RW, Powell MA, Nowicka M, Schaefer G, Merchant M, Yan Y. Mutch D, et al. Among authors: merchant m. Cancer. 2024 Jun 1;130(11):1940-1951. doi: 10.1002/cncr.35222. Epub 2024 Jan 30. Cancer. 2024. PMID: 38288862 Clinical Trial.
Outer Membrane Vesicles Released from Garlic Exosome-like Nanoparticles (GaELNs) Train Gut Bacteria that Reverses Type 2 Diabetes via the Gut-Brain Axis.
Sundaram K, Teng Y, Mu J, Xu Q, Xu F, Sriwastva MK, Zhang L, Park JW, Zhang X, Yan J, Zhang SQ, Merchant ML, Chen SY, McClain CJ, Dryden GW, Zhang HG. Sundaram K, et al. Among authors: merchant ml. Small. 2024 May;20(20):e2308680. doi: 10.1002/smll.202308680. Epub 2024 Jan 15. Small. 2024. PMID: 38225709
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, Chan EW, Chen H, Chen X, Cheng Y, Cheung TK, Davenport K, DiNicola D, Gordon D, Hamman BD, Harbin A, Haskell R, He M, Hole AJ, Januario T, Kerry PS, Koenig SG, Li L, Merchant M, Pérez-Dorado I, Pizzano J, Quinn C, Rose CM, Rousseau E, Soto L, Staben LR, Sun H, Tian Q, Wang J, Wang W, Ye CS, Ye X, Zhang P, Zhou Y, Yauch R, Dragovich PS. Berlin M, et al. Among authors: merchant m. J Med Chem. 2024 Jan 25;67(2):1262-1313. doi: 10.1021/acs.jmedchem.3c01781. Epub 2024 Jan 5. J Med Chem. 2024. PMID: 38180485
Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy.
Kaczanowska S, Murty T, Alimadadi A, Contreras CF, Duault C, Subrahmanyam PB, Reynolds W, Gutierrez NA, Baskar R, Wu CJ, Michor F, Altreuter J, Liu Y, Jhaveri A, Duong V, Anbunathan H, Ong C, Zhang H, Moravec R, Yu J, Biswas R, Van Nostrand S, Lindsay J, Pichavant M, Sotillo E, Bernstein D, Carbonell A, Derdak J, Klicka-Skeels J, Segal JE, Dombi E, Harmon SA, Turkbey B, Sahaf B, Bendall S, Maecker H, Highfill SL, Stroncek D, Glod J, Merchant M, Hedrick CC, Mackall CL, Ramakrishna S, Kaplan RN. Kaczanowska S, et al. Among authors: merchant m. Cancer Cell. 2024 Jan 8;42(1):35-51.e8. doi: 10.1016/j.ccell.2023.11.011. Epub 2023 Dec 21. Cancer Cell. 2024. PMID: 38134936
Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib.
Pang Y, Li Q, Sergi Z, Yu G, Sang X, Kim O, Wang H, Ranjan A, Merchant M, Oudit B, Robey RW, Soheilian F, Tran B, Núñez FJ, Zhang M, Song H, Zhang W, Davis D, Gilbert MR, Gottesman MM, Liu Z, Khan J, Thomas CJ, Castro MG, Gujral TS, Wu J. Pang Y, et al. Among authors: merchant m. bioRxiv [Preprint]. 2024 Jan 2:2023.06.29.547143. doi: 10.1101/2023.06.29.547143. bioRxiv. 2024. PMID: 37786680 Free PMC article. Preprint.
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
Taylor AM, Williams BR, Giordanetto F, Kelley EH, Lescarbeau A, Shortsleeves K, Tang Y, Walters WP, Arrazate A, Bowman C, Brophy E, Chan EW, Deshmukh G, Greisman JB, Hunsaker TL, Kipp DR, Saenz Lopez-Larrocha P, Maddalo D, Martin IJ, Maragakis P, Merchant M, Murcko M, Nisonoff H, Nguyen V, Nguyen V, Orozco O, Owen C, Pierce L, Schmidt M, Shaw DE, Smith S, Therrien E, Tran JC, Watters J, Waters NJ, Wilbur J, Willmore L. Taylor AM, et al. Among authors: merchant m. J Med Chem. 2023 Oct 12;66(19):13384-13399. doi: 10.1021/acs.jmedchem.3c00483. Epub 2023 Sep 29. J Med Chem. 2023. PMID: 37774359
Combined inhibition of topoisomerase I and poly(ADP-ribose) polymerase: A synergistic therapeutic strategy for glioblastoma with phosphatase and tensin homolog deficiency.
Kim O, Butler M, Sergi Z, Robey RW, Zhang M, Chari R, Pang Y, Yu G, Zhang W, Song H, Davis D, Hawley RG, Wen X, Wang H, Quezado M, Tran B, Merchant M, Ranjan A, Furnari FB, Khan J, Gilbert MR, Ryan Miller C, Gottesman MM, Pommier Y, Wu J. Kim O, et al. Among authors: merchant m. Neurooncol Adv. 2023 Aug 21;5(1):vdad102. doi: 10.1093/noajnl/vdad102. eCollection 2023 Jan-Dec. Neurooncol Adv. 2023. PMID: 37706203 Free PMC article.
Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patient-Specific" Approach.
Bhayana S, Zhao Y, Merchant M, Cummins T, Dougherty JA, Kamigaki Y, Pathmasiri W, McRitchie S, Mariani LH, Sumner S, Klein JB, Li L, Smoyer WE; Pediatric Nephrology Research Consortium. Bhayana S, et al. Among authors: merchant m. Kidney Int Rep. 2023 Mar 23;8(6):1239-1254. doi: 10.1016/j.ekir.2023.03.015. eCollection 2023 Jun. Kidney Int Rep. 2023. PMID: 37284673 Free PMC article.
Quantification of damage to plasmid DNA from 35 MeV electrons, 228 MeV protons and 300 kVp X-rays in varying hydroxyl radical scavenging environments.
Wanstall HC, Henthorn NT, Jones J, Santina E, Chadwick AL, Angal-Kalinin D, Morris G, Warmenhoven JW, Smith R, Mathisen S, Merchant MJ, Jones RM. Wanstall HC, et al. Among authors: merchant mj. J Radiat Res. 2023 May 6;64(3):547-57. doi: 10.1093/jrr/rrad032. Online ahead of print. J Radiat Res. 2023. PMID: 37154587 Free PMC article.
MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis.
Del Rosario O, Suresh K, Kallem M, Singh G, Shah A, Zheng L, Yun X, Philip NM, Putcha N, McClure MB, Jiang H, D'Alessio F, Srivastava M, Bera A, Shimoda LA, Merchant M, Rane MJ, Machamer CE, Mock J, Hagan R, Koch AL, Punjabi NM, Kolb TM, Damarla M. Del Rosario O, et al. Among authors: merchant m. Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L700-L711. doi: 10.1152/ajplung.00340.2022. Epub 2023 Mar 28. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36976920 Free PMC article.
Proton Beam Therapy in Breast Cancer Patients: The UK PARABLE Trial is Recruiting.
Kirby AM, Haviland JS, Mackenzie M, Fleming H, Anandadas C, Wickers S, Miles E, Iles N, Bliss JM, Coles CE; PARABLE Trial Management Group. Kirby AM, et al. Clin Oncol (R Coll Radiol). 2023 Jun;35(6):347-350. doi: 10.1016/j.clon.2023.02.015. Epub 2023 Mar 2. Clin Oncol (R Coll Radiol). 2023. PMID: 36933970 No abstract available.
Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.
de Jesus AA, Chen G, Yang D, Brdicka T, Ruth NM, Bennin D, Cebecauerova D, Malcova H, Freeman H, Martin N, Svojgr K, Passo MH, Bhuyan F, Alehashemi S, Rastegar AT, Uss K, Kardava L, Marrero B, Duric I, Omoyinmi E, Peldova P, Lee CR, Kleiner DE, Hadigan CM, Hewitt SM, Pittaluga S, Carmona-Rivera C, Calvo KR, Shah N, Balascakova M, Fink DL, Kotalova R, Parackova Z, Peterkova L, Kuzilkova D, Campr V, Sramkova L, Biancotto A, Brooks SR, Manes C, Meffre E, Harper RL, Kuehn H, Kaplan MJ, Brogan P, Rosenzweig SD, Merchant M, Deng Z, Huttenlocher A, Moir SL, Kuhns DB, Boehm M, Skvarova Kramarzova K, Goldbach-Mansky R. de Jesus AA, et al. Among authors: merchant m. Nat Commun. 2023 Mar 17;14(1):1502. doi: 10.1038/s41467-023-36941-y. Nat Commun. 2023. PMID: 36932076 Free PMC article.
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer.
Suresh K, Del Rosario O, Kallem M, Singh G, Shah A, Zheng L, Yun X, Philip NM, Putcha N, McClure MB, Jiang H, D'Alessio F, Srivastava M, Bera A, Shimoda LA, Merchant M, Rane MJ, Machamer CE, Mock J, Hagan R, Koch AL, Punjabi NM, Kolb TM, Damarla M. Suresh K, et al. Among authors: merchant m. Physiol Genomics. 2023 Apr 1;55(4):168-178. doi: 10.1152/physiolgenomics.00155.2022. Epub 2023 Mar 6. Physiol Genomics. 2023. PMID: 36878491 Free PMC article.
Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry.
Tran JC, Hunsaker T, Bell C, Ma TP, Chan E, Larrocha PS, Homyk K, Liu L, La H, Mao J, de la Cruz CC, Yu K, Beresini M, Forrest WF, Xiao Y, Jang A, Samus N, Stesco ND, Mentinova M, Parent S, Pottiez G, Schirm M, Purkey HE, Liu Y, Merchant M. Tran JC, et al. Among authors: merchant m. Anal Chem. 2023 Mar 21;95(11):4834-4839. doi: 10.1021/acs.analchem.2c04417. Epub 2023 Mar 6. Anal Chem. 2023. PMID: 36876898
Proposing a Clinical Model for RBE Based on Proton Track-End Counts.
Henthorn NT, Gardner LL, Aitkenhead AH, Rowland BC, Shin J, Smith EAK, Merchant MJ, Mackay RI, Kirkby KJ, Chaudhary P, Prise KM, McMahon SJ, Underwood TSA. Henthorn NT, et al. Among authors: merchant mj. Int J Radiat Oncol Biol Phys. 2023 Jul 15;116(4):916-926. doi: 10.1016/j.ijrobp.2022.12.056. Epub 2023 Jan 13. Int J Radiat Oncol Biol Phys. 2023. PMID: 36642109
Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2.
Sato T, Head KZ, Li J, Dolin CE, Wilkey D, Skirtich N, Smith K, McCreary DD, Liu S, Beier JI, Singhi AD, McEnaney RM, Merchant ML, Arteel GE. Sato T, et al. Among authors: merchant ml. Matrix Biol Plus. 2022 Dec 28;17:100127. doi: 10.1016/j.mbplus.2022.100127. eCollection 2023 Feb. Matrix Biol Plus. 2022. PMID: 36632559 Free PMC article.
CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.
Huseni MA, Wang L, Klementowicz JE, Yuen K, Breart B, Orr C, Liu LF, Li Y, Gupta V, Li C, Rishipathak D, Peng J, Şenbabaoǧlu Y, Modrusan Z, Keerthivasan S, Madireddi S, Chen YJ, Fraser EJ, Leng N, Hamidi H, Koeppen H, Ziai J, Hashimoto K, Fassò M, Williams P, McDermott DF, Rosenberg JE, Powles T, Emens LA, Hegde PS, Mellman I, Turley SJ, Wilson MS, Mariathasan S, Molinero L, Merchant M, West NR. Huseni MA, et al. Among authors: merchant m. Cell Rep Med. 2023 Jan 17;4(1):100878. doi: 10.1016/j.xcrm.2022.100878. Epub 2023 Jan 3. Cell Rep Med. 2023. PMID: 36599350 Free PMC article.
Demographic, Reproductive, and Medical Risk Factors for Intrauterine Device Expulsion.
Anthony MS, Zhou X, Schoendorf J, Reed SD, Getahun D, Armstrong MA, Gatz J, Peipert JF, Raine-Bennett T, Fassett MJ, Saltus CW, Ritchey ME, Ichikawa L, Shi JM, Alabaster A, Wahdan Y, Wang J, Xie F, Merchant M, Hunter S, Chiu VY, Postlethwaite D, Rothman KJ, Im TM, Chillemi G, Takhar HS, Asiimwe A, Pisa F. Anthony MS, et al. Among authors: merchant m. Obstet Gynecol. 2022 Dec 1;140(6):1017-1030. doi: 10.1097/AOG.0000000000005000. Epub 2022 Nov 2. Obstet Gynecol. 2022. PMID: 36357958 Free PMC article. Clinical Trial.
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Cantley J, Ye X, Rousseau E, Januario T, Hamman BD, Rose CM, Cheung TK, Hinkle T, Soto L, Quinn C, Harbin A, Bortolon E, Chen X, Haskell R, Lin E, Yu SF, Del Rosario G, Chan E, Dunlap D, Koeppen H, Martin S, Merchant M, Grimmer M, Broccatelli F, Wang J, Pizzano J, Dragovich PS, Berlin M, Yauch RL. Cantley J, et al. Among authors: merchant m. Nat Commun. 2022 Nov 10;13(1):6814. doi: 10.1038/s41467-022-34562-5. Nat Commun. 2022. PMID: 36357397 Free PMC article.
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