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Page 1
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Müller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, van Rooijen N, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J. Machnik A, et al. Among authors: van rooijen n. Nat Med. 2009 May;15(5):545-52. doi: 10.1038/nm.1960. Epub 2009 May 3. Nat Med. 2009. PMID: 19412173
Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats.
Machnik A, Dahlmann A, Kopp C, Goss J, Wagner H, van Rooijen N, Eckardt KU, Müller DN, Park JK, Luft FC, Kerjaschki D, Titze J. Machnik A, et al. Among authors: van rooijen n. Hypertension. 2010 Mar;55(3):755-61. doi: 10.1161/HYPERTENSIONAHA.109.143339. Epub 2010 Feb 8. Hypertension. 2010. PMID: 20142563 Free article.
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia.
Ramos P, Casu C, Gardenghi S, Breda L, Crielaard BJ, Guy E, Marongiu MF, Gupta R, Levine RL, Abdel-Wahab O, Ebert BL, Van Rooijen N, Ghaffari S, Grady RW, Giardina PJ, Rivella S. Ramos P, et al. Among authors: van rooijen n. Nat Med. 2013 Apr;19(4):437-45. doi: 10.1038/nm.3126. Epub 2013 Mar 17. Nat Med. 2013. PMID: 23502961 Free PMC article.
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE. von Moltke J, et al. Among authors: van rooijen n. Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351. Epub 2012 Aug 19. Nature. 2012. PMID: 22902502 Free PMC article.
Blood pressure control: a facelift for macrophages?
Schmaderer C, Eissler R, Seibel S, van Rooijen N, Baumann M. Schmaderer C, et al. Among authors: van rooijen n. Hypertension. 2010 Aug;56(2):e23; author reply e24. doi: 10.1161/HYPERTENSIONAHA.110.155408. Epub 2010 Jun 14. Hypertension. 2010. PMID: 20547967 No abstract available.
Phagocyte-derived catecholamines enhance acute inflammatory injury.
Flierl MA, Rittirsch D, Nadeau BA, Chen AJ, Sarma JV, Zetoune FS, McGuire SR, List RP, Day DE, Hoesel LM, Gao H, Van Rooijen N, Huber-Lang MS, Neubig RR, Ward PA. Flierl MA, et al. Among authors: van rooijen n. Nature. 2007 Oct 11;449(7163):721-5. doi: 10.1038/nature06185. Epub 2007 Sep 30. Nature. 2007. PMID: 17914358 Free article.
Macrophage depletion lowers blood pressure and restores sympathetic nerve α2-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats.
Thang LV, Demel SL, Crawford R, Kaminski NE, Swain GM, Van Rooijen N, Galligan JJ. Thang LV, et al. Among authors: van rooijen n. Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1186-97. doi: 10.1152/ajpheart.00283.2015. Epub 2015 Aug 28. Am J Physiol Heart Circ Physiol. 2015. PMID: 26320034 Free PMC article.
Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Robbins CS, et al. Among authors: van rooijen n. Nat Med. 2013 Sep;19(9):1166-72. doi: 10.1038/nm.3258. Epub 2013 Aug 11. Nat Med. 2013. PMID: 23933982 Free PMC article.
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA. Huang LR, et al. Among authors: van rooijen n. Nat Immunol. 2013 Jun;14(6):574-83. doi: 10.1038/ni.2573. Epub 2013 Apr 14. Nat Immunol. 2013. PMID: 23584070
Macrophage-dependent impairment of α2-adrenergic autoreceptor inhibition of Ca2+ channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats.
Mui RK, Fernandes RN, Garver HG, Van Rooijen N, Galligan JJ. Mui RK, et al. Among authors: van rooijen n. Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H863-H877. doi: 10.1152/ajpheart.00536.2017. Epub 2018 Jan 5. Am J Physiol Heart Circ Physiol. 2018. PMID: 29351460 Free PMC article.
Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors.
Chuah MK, Schiedner G, Thorrez L, Brown B, Johnston M, Gillijns V, Hertel S, Van Rooijen N, Lillicrap D, Collen D, VandenDriessche T, Kochanek S. Chuah MK, et al. Among authors: van rooijen n. Blood. 2003 Mar 1;101(5):1734-43. doi: 10.1182/blood-2002-03-0823. Epub 2002 Oct 24. Blood. 2003. PMID: 12406898 Free article.
Macrophages direct tumour histology and clinical outcome in a colon cancer model.
Oosterling SJ, van der Bij GJ, Meijer GA, Tuk CW, van Garderen E, van Rooijen N, Meijer S, van der Sijp JR, Beelen RH, van Egmond M. Oosterling SJ, et al. Among authors: van der bij gj, van rooijen n, van egmond m, van garderen e, van der sijp jr. J Pathol. 2005 Oct;207(2):147-55. doi: 10.1002/path.1830. J Pathol. 2005. PMID: 16104052
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ. Bird TG, et al. Among authors: van rooijen n. Sci Transl Med. 2018 Aug 15;10(454):eaan1230. doi: 10.1126/scitranslmed.aan1230. Sci Transl Med. 2018. PMID: 30111642 Free PMC article.
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.
Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, Phythian-Adams AT, van Rooijen N, Haslett C, Howie SE, Simpson AJ, Hirani N, Gauldie J, Iredale JP, Sethi T, Forbes SJ. Gibbons MA, et al. Among authors: van rooijen n. Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81. doi: 10.1164/rccm.201010-1719OC. Am J Respir Crit Care Med. 2011. PMID: 21680953
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.
Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, Hartland SN, Snowdon VK, Cappon A, Gordon-Walker TT, Williams MJ, Dunbar DR, Manning JR, van Rooijen N, Fallowfield JA, Forbes SJ, Iredale JP. Ramachandran P, et al. Among authors: van rooijen n. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3186-95. doi: 10.1073/pnas.1119964109. Epub 2012 Oct 24. Proc Natl Acad Sci U S A. 2012. PMID: 23100531 Free PMC article.
WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
Boulter L, Guest RV, Kendall TJ, Wilson DH, Wojtacha D, Robson AJ, Ridgway RA, Samuel K, Van Rooijen N, Barry ST, Wigmore SJ, Sansom OJ, Forbes SJ. Boulter L, et al. Among authors: van rooijen n. J Clin Invest. 2015 Mar 2;125(3):1269-85. doi: 10.1172/JCI76452. Epub 2015 Feb 17. J Clin Invest. 2015. PMID: 25689248 Free PMC article.
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
Chow A, Lucas D, Hidalgo A, Méndez-Ferrer S, Hashimoto D, Scheiermann C, Battista M, Leboeuf M, Prophete C, van Rooijen N, Tanaka M, Merad M, Frenette PS. Chow A, et al. Among authors: van rooijen n. J Exp Med. 2011 Feb 14;208(2):261-71. doi: 10.1084/jem.20101688. Epub 2011 Jan 31. J Exp Med. 2011. PMID: 21282381 Free PMC article.
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation.
Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M. Hashimoto D, et al. Among authors: van rooijen n. J Exp Med. 2011 May 9;208(5):1069-82. doi: 10.1084/jem.20101709. Epub 2011 May 2. J Exp Med. 2011. PMID: 21536742 Free PMC article.
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.
Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M. Hashimoto D, et al. Among authors: van rooijen n. Immunity. 2013 Apr 18;38(4):792-804. doi: 10.1016/j.immuni.2013.04.004. Immunity. 2013. PMID: 23601688 Free PMC article.
Rhythmic modulation of the hematopoietic niche through neutrophil clearance.
Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Casanova-Acebes M, et al. Among authors: van rooijen n. Cell. 2013 May 23;153(5):1025-35. doi: 10.1016/j.cell.2013.04.040. Cell. 2013. PMID: 23706740 Free PMC article.
Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity.
Carlos CP, Mendes GE, Miquelin AR, Luz MA, da Silva CG, van Rooijen N, Coimbra TM, Burdmann EA. Carlos CP, et al. Among authors: van rooijen n. Transplantation. 2010 Jun 15;89(11):1362-70. doi: 10.1097/tp.0b013e3181da0587. Transplantation. 2010. PMID: 20535850
Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.
Shinde PV, Xu HC, Maney SK, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev VI, van Rooijen N, Scheu S, Pfeffer K, Crocker PR, Tanaka M, Duggimpudi S, Knolle P, Heikenwalder M, Ruland J, Mak TW, Brenner D, Pandyra AA, Hoell JI, Borkhardt A, Häussinger D, Lang KS, Lang PA. Shinde PV, et al. Among authors: van rooijen n. J Virol. 2018 Jan 17;92(3):e01637-17. doi: 10.1128/JVI.01637-17. Print 2018 Feb 1. J Virol. 2018. PMID: 29142134 Free PMC article.
Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation.
Weisser SB, Kozicky LK, Brugger HK, Ngoh EN, Cheung B, Jen R, Menzies SC, Samarakoon A, Murray PJ, Lim CJ, Johnson P, Boucher JL, van Rooijen N, Sly LM. Weisser SB, et al. Among authors: van rooijen n. Eur J Immunol. 2014 Nov;44(11):3353-67. doi: 10.1002/eji.201343981. Epub 2014 Sep 25. Eur J Immunol. 2014. PMID: 25124254 Free article.
861 results