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Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849+10 kb C-to-T splicing mutation.
Oren YS, Irony-Tur Sinai M, Golec A, Barchad-Avitzur O, Mutyam V, Li Y, Hong J, Ozeri-Galai E, Hatton A, Leibson C, Carmel L, Reiter J, Sorscher EJ, Wilton SD, Kerem E, Rowe SM, Sermet-Gaudelus I, Kerem B. Oren YS, et al. Among authors: irony tur sinai m. J Cyst Fibros. 2021 Sep;20(5):865-875. doi: 10.1016/j.jcf.2021.06.003. Epub 2021 Jul 2. J Cyst Fibros. 2021. PMID: 34226157 Free PMC article.
AT-dinucleotide rich sequences drive fragile site formation.
Irony-Tur Sinai M, Salamon A, Stanleigh N, Goldberg T, Weiss A, Wang YH, Kerem B. Irony-Tur Sinai M, et al. Nucleic Acids Res. 2019 Oct 10;47(18):9685-9695. doi: 10.1093/nar/gkz689. Nucleic Acids Res. 2019. PMID: 31410468 Free PMC article.
3D genome organization contributes to genome instability at fragile sites.
Sarni D, Sasaki T, Irony Tur-Sinai M, Miron K, Rivera-Mulia JC, Magnuson B, Ljungman M, Gilbert DM, Kerem B. Sarni D, et al. Among authors: irony tur sinai m. Nat Commun. 2020 Jul 17;11(1):3613. doi: 10.1038/s41467-020-17448-2. Nat Commun. 2020. PMID: 32680994 Free PMC article.
Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14·TRAIL.
Prinz-Hadad H, Mizrachi T, Irony-Tur-Sinai M, Prigozhina TB, Aronin A, Brenner T, Dranitzki-Elhalel M. Prinz-Hadad H, et al. Among authors: irony tur sinai m. J Neuroinflammation. 2013 Mar 9;10:36. doi: 10.1186/1742-2094-10-36. J Neuroinflammation. 2013. PMID: 23497038 Free PMC article.