Shi L - Search Results

1

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain.

Bezerra GA, Holenstein A, Foster WR, Xie B, Hicks KG, Bürer C, Lutz S, Mukherjee A, Sarkar D, Bhattacharya D, Rutter J, Talukdar A, Brown PJ, Luo M, Shi L, Froese DS, Yue WW. Bezerra GA, et al. Among authors: shi l. Biochimie. 2021 Apr;183:100-107. doi: 10.1016/j.biochi.2021.01.007. Epub 2021 Jan 18. Biochimie. 2021. PMID: 33476699 Free PMC article.

2

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.

Cai XC, Zhang T, Kim EJ, Jiang M, Wang K, Wang J, Chen S, Zhang N, Wu H, Li F, Dela Seña CC, Zeng H, Vivcharuk V, Niu X, Zheng W, Lee JP, Chen Y, Barsyte D, Szewczyk M, Hajian T, Ibáñez G, Dong A, Dombrovski L, Zhang Z, Deng H, Min J, Arrowsmith CH, Mazutis L, Shi L, Vedadi M, Brown PJ, Xiang J, Qin LX, Xu W, Luo M. Cai XC, et al. Among authors: shi l. Elife. 2019 Oct 28;8:e47110. doi: 10.7554/eLife.47110. Elife. 2019. PMID: 31657716 Free PMC article.

3

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor.

Adhikari P, Xie B, Semeano A, Bonifazi A, Battiti FO, Newman AH, Yano H, Shi L. Adhikari P, et al. Among authors: shi l. Biomolecules. 2021 Apr 13;11(4):570. doi: 10.3390/biom11040570. Biomolecules. 2021. PMID: 33924613 Free PMC article.

4

Computational Modeling of C-Terminal Tails to Predict the Calcium-Dependent Secretion of Endoplasmic Reticulum Resident Proteins.

Trychta KA, Xie B, Verma RK, Xu M, Shi L, Harvey BK. Trychta KA, et al. Among authors: shi l. Front Chem. 2021 Jun 29;9:689608. doi: 10.3389/fchem.2021.689608. eCollection 2021. Front Chem. 2021. PMID: 34268295 Free PMC article.

5

Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D₂ Dopamine Receptor.

Free RB, Cuoco CA, Xie B, Namkung Y, Prabhu VV, Willette BKA, Day MM, Sanchez-Soto M, Lane JR, Laporte SA, Shi L, Allen JE, Sibley DR. Free RB, et al. Among authors: shi l. Mol Pharmacol. 2021 Oct;100(4):372-387. doi: 10.1124/molpharm.121.000336. Epub 2021 Aug 5. Mol Pharmacol. 2021. PMID: 34353882 Free PMC article.

6

A comprehensive evaluation of the potential binding poses of fentanyl and its analogs at the µ-opioid receptor.

Xie B, Goldberg A, Shi L. Xie B, et al. Among authors: shi l. Comput Struct Biotechnol J. 2022 May 14;20:2309-2321. doi: 10.1016/j.csbj.2022.05.013. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35615021 Free PMC article.

7

The Molecular Mechanism of Positive Allosteric Modulation at the Dopamine D1 Receptor.

Goldberg A, Xie B, Shi L. Goldberg A, et al. Among authors: shi l. Int J Mol Sci. 2023 Aug 16;24(16):12848. doi: 10.3390/ijms241612848. Int J Mol Sci. 2023. PMID: 37629030 Free PMC article.

8

GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.

Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, Lefkowitz RJ, Blanchard SC, Javitch JA. Asher WB, et al. Among authors: shi l. Cell. 2022 May 12;185(10):1661-1675.e16. doi: 10.1016/j.cell.2022.03.042. Epub 2022 Apr 27. Cell. 2022. PMID: 35483373 Free PMC article.

9

A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.

Chambers DR, Sulima A, Luo D, Prisinzano TE, Goldberg A, Xie B, Shi L, Paronis CA, Bergman J, Nassehi N, Selley DE, Imler GH, Jacobson AE, Rice KC. Chambers DR, et al. Among authors: shi l. Molecules. 2022 Sep 30;27(19):6455. doi: 10.3390/molecules27196455. Molecules. 2022. PMID: 36234992 Free PMC article.

10

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand.

Mistry SN, Shonberg J, Draper-Joyce CJ, Klein Herenbrink C, Michino M, Shi L, Christopoulos A, Capuano B, Scammells PJ, Lane JR. Mistry SN, et al. Among authors: shi l. J Med Chem. 2015 Sep 10;58(17):6819-43. doi: 10.1021/acs.jmedchem.5b00585. Epub 2015 Aug 28. J Med Chem. 2015. PMID: 26258690 Free PMC article.

11

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D₃ Receptor (D₃R).

Kumar V, Moritz AE, Keck TM, Bonifazi A, Ellenberger MP, Sibley CD, Free RB, Shi L, Lane JR, Sibley DR, Newman AH. Kumar V, et al. Among authors: shi l. J Med Chem. 2017 Feb 23;60(4):1478-1494. doi: 10.1021/acs.jmedchem.6b01688. Epub 2017 Feb 10. J Med Chem. 2017. PMID: 28186762 Free PMC article.

12

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

Verma RK, Abramyan AM, Michino M, Free RB, Sibley DR, Javitch JA, Lane JR, Shi L. Verma RK, et al. Among authors: shi l. PLoS Comput Biol. 2018 Jan 16;14(1):e1005948. doi: 10.1371/journal.pcbi.1005948. eCollection 2018 Jan. PLoS Comput Biol. 2018. PMID: 29337986 Free PMC article.

13

The action of a negative allosteric modulator at the dopamine D₂ receptor is dependent upon sodium ions.

Draper-Joyce CJ, Verma RK, Michino M, Shonberg J, Kopinathan A, Klein Herenbrink C, Scammells PJ, Capuano B, Abramyan AM, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR. Draper-Joyce CJ, et al. Among authors: shi l. Sci Rep. 2018 Jan 19;8(1):1208. doi: 10.1038/s41598-018-19642-1. Sci Rep. 2018. PMID: 29352161 Free PMC article.

14

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter.

Plenge P, Abramyan AM, Sørensen G, Mørk A, Weikop P, Gether U, Bang-Andersen B, Shi L, Loland CJ. Plenge P, et al. Among authors: shi l. Nat Commun. 2020 Mar 20;11(1):1491. doi: 10.1038/s41467-020-15292-y. Nat Commun. 2020. PMID: 32198394 Free PMC article.

15

Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.

Cai XC, Zhang T, Kim EJ, Jiang M, Wang K, Wang J, Chen S, Zhang N, Wu H, Li F, Dela Seña CC, Zeng H, Vivcharuk V, Niu X, Zheng W, Lee JP, Chen Y, Barsyte D, Szewczyk M, Hajian T, Ibáñez G, Dong A, Dombrovski L, Zhang Z, Deng H, Min J, Arrowsmith CH, Mazutis L, Shi L, Vedadi M, Brown PJ, Xiang J, Qin LX, Xu W, Luo M. Cai XC, et al. Among authors: shi l. Elife. 2020 Oct 15;9:e63994. doi: 10.7554/eLife.63994. Elife. 2020. PMID: 33054974 Free PMC article.

16

The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.

Shan J, Javitch JA, Shi L, Weinstein H. Shan J, et al. Among authors: shi l. PLoS One. 2011 Jan 27;6(1):e16350. doi: 10.1371/journal.pone.0016350. PLoS One. 2011. PMID: 21298009 Free PMC article.

17

Computational approaches to detect allosteric pathways in transmembrane molecular machines.

Stolzenberg S, Michino M, LeVine MV, Weinstein H, Shi L. Stolzenberg S, et al. Among authors: shi l. Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1652-62. doi: 10.1016/j.bbamem.2016.01.010. Epub 2016 Jan 22. Biochim Biophys Acta. 2016. PMID: 26806157 Free PMC article.

18

The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.

Stolzenberg S, Li Z, Quick M, Malinauskaite L, Nissen P, Weinstein H, Javitch JA, Shi L. Stolzenberg S, et al. Among authors: shi l. J Biol Chem. 2017 May 5;292(18):7372-7384. doi: 10.1074/jbc.M116.757153. Epub 2017 Mar 20. J Biol Chem. 2017. PMID: 28320858 Free PMC article.

19

Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design.

Keck TM, Burzynski C, Shi L, Newman AH. Keck TM, et al. Among authors: shi l. Adv Pharmacol. 2014;69:267-300. doi: 10.1016/B978-0-12-420118-7.00007-X. Adv Pharmacol. 2014. PMID: 24484980 Free PMC article. Review.

20

Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors.

Michino M, Free RB, Doyle TB, Sibley DR, Shi L. Michino M, et al. Among authors: shi l. Chem Commun (Camb). 2015 May 21;51(41):8618-21. doi: 10.1039/c5cc02204e. Chem Commun (Camb). 2015. PMID: 25896577 Free PMC article.

21

A new mechanism of allostery in a G protein-coupled receptor dimer.

Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A. Lane JR, et al. Among authors: shi l. Nat Chem Biol. 2014 Sep;10(9):745-52. doi: 10.1038/nchembio.1593. Epub 2014 Aug 10. Nat Chem Biol. 2014. PMID: 25108820 Free PMC article.

22

Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D₂ Receptor (D₂R) Biased Agonism.

Bonifazi A, Yano H, Ellenberger MP, Muller L, Kumar V, Zou MF, Cai NS, Guerrero AM, Woods AS, Shi L, Newman AH. Bonifazi A, et al. Among authors: shi l. J Med Chem. 2017 Apr 13;60(7):2890-2907. doi: 10.1021/acs.jmedchem.6b01875. Epub 2017 Mar 16. J Med Chem. 2017. PMID: 28300398 Free PMC article.

23

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D₂ receptor.

Draper-Joyce CJ, Michino M, Verma RK, Klein Herenbrink C, Shonberg J, Kopinathan A, Scammells PJ, Capuano B, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR. Draper-Joyce CJ, et al. Among authors: shi l. Biochem Pharmacol. 2018 Feb;148:315-328. doi: 10.1016/j.bcp.2018.01.002. Epub 2018 Jan 9. Biochem Pharmacol. 2018. PMID: 29325769 Free PMC article.

24

The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.

Quick M, Abramyan AM, Wiriyasermkul P, Weinstein H, Shi L, Javitch JA. Quick M, et al. Among authors: shi l. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7924-E7931. doi: 10.1073/pnas.1717444115. Epub 2018 Aug 6. Proc Natl Acad Sci U S A. 2018. PMID: 30082383 Free PMC article.

25

Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors.

Salomon K, Abramyan AM, Plenge P, Wang L, Bundgaard C, Bang-Andersen B, Loland CJ, Shi L. Salomon K, et al. Among authors: shi l. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2304089120. doi: 10.1073/pnas.2304089120. Epub 2023 Oct 4. Proc Natl Acad Sci U S A. 2023. PMID: 37792512 Free PMC article.

26

Editorial: Computer Aided Structure-based Lead Optimization.

Beuming T, Shi L. Beuming T, et al. Among authors: shi l. Curr Top Med Chem. 2017;17(23):2575-2576. doi: 10.2174/156802661723170808161306. Curr Top Med Chem. 2017. PMID: 28889794 No abstract available.

27

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism.

Lane JR, Abramyan AM, Adhikari P, Keen AC, Lee KH, Sanchez J, Verma RK, Lim HD, Yano H, Javitch JA, Shi L. Lane JR, et al. Among authors: shi l. Elife. 2020 Jan 27;9:e52189. doi: 10.7554/eLife.52189. Elife. 2020. PMID: 31985399 Free PMC article.

28

Allostery and binding cooperativity of the catalytic subunit of protein kinase A by NMR spectroscopy and molecular dynamics simulations.

Masterson LR, Cembran A, Shi L, Veglia G. Masterson LR, et al. Among authors: shi l. Adv Protein Chem Struct Biol. 2012;87:363-89. doi: 10.1016/B978-0-12-398312-1.00012-3. Adv Protein Chem Struct Biol. 2012. PMID: 22607761 Free PMC article. Review.

29

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

Michino M, Donthamsetti P, Beuming T, Banala A, Duan L, Roux T, Han Y, Trinquet E, Newman AH, Javitch JA, Shi L. Michino M, et al. Among authors: shi l. Mol Pharmacol. 2013 Dec;84(6):854-64. doi: 10.1124/mol.113.087833. Epub 2013 Sep 23. Mol Pharmacol. 2013. PMID: 24061855 Free PMC article.

30

The Glu102 mutation disrupts higher-order oligomerization of the sigma 1 receptor.

Abramyan AM, Yano H, Xu M, Liu L, Naing S, Fant AD, Shi L. Abramyan AM, et al. Among authors: shi l. Comput Struct Biotechnol J. 2020 Jan 7;18:199-206. doi: 10.1016/j.csbj.2019.12.012. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 32055286 Free PMC article.

31

The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias.

Tsai MM, Chen L, Baumann MH, Canals M, Javitch JA, Lane JR, Shi L. Tsai MM, et al. Among authors: shi l. bioRxiv [Preprint]. 2023 Nov 15:2023.11.10.566672. doi: 10.1101/2023.11.10.566672. bioRxiv. 2023. PMID: 38014284 Free PMC article. Updated. Preprint.

32

Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.

Khelashvili G, Doktorova M, Sahai MA, Johner N, Shi L, Weinstein H. Khelashvili G, et al. Among authors: shi l. Proteins. 2015 May;83(5):952-69. doi: 10.1002/prot.24792. Epub 2015 Mar 25. Proteins. 2015. PMID: 25739722 Free PMC article.

33

Novel and Potent Dopamine D₂ Receptor Go-Protein Biased Agonists.

Bonifazi A, Yano H, Guerrero AM, Kumar V, Hoffman AF, Lupica CR, Shi L, Newman AH. Bonifazi A, et al. Among authors: shi l. ACS Pharmacol Transl Sci. 2019 Feb 8;2(1):52-65. doi: 10.1021/acsptsci.8b00060. Epub 2019 Jan 14. ACS Pharmacol Transl Sci. 2019. PMID: 30775693 Free PMC article.

34

The Effects of Terminal Tagging on Homomeric Interactions of the Sigma 1 Receptor.

Yano H, Liu L, Naing S, Shi L. Yano H, et al. Among authors: shi l. Front Neurosci. 2019 Dec 19;13:1356. doi: 10.3389/fnins.2019.01356. eCollection 2019. Front Neurosci. 2019. PMID: 31920515 Free PMC article.

35

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.

Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, Barnaeva E, Ferrer M, Javitch JA, Beuming T, Shi L, Southall NT, Marugan JJ, Sibley DR. Free RB, et al. Among authors: shi l. Mol Pharmacol. 2014 Jul;86(1):96-105. doi: 10.1124/mol.113.090563. Epub 2014 Apr 22. Mol Pharmacol. 2014. PMID: 24755247 Free PMC article.

36

Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles.

LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H. LeVine MV, et al. Among authors: shi l. Biochemistry. 2016 Feb 16;55(6):850-9. doi: 10.1021/acs.biochem.5b01268. Epub 2016 Feb 5. Biochemistry. 2016. PMID: 26811944 Free PMC article.

37

Unraveling activation-related rearrangements and intrinsic divergence from ligand-induced conformational changes of the dopamine D3 and D2 receptors.

Lee KH, Shi L. Lee KH, et al. Among authors: shi l. bioRxiv [Preprint]. 2023 Nov 14:2023.11.11.566699. doi: 10.1101/2023.11.11.566699. bioRxiv. 2023. PMID: 38014309 Free PMC article. Updated. Preprint.

38

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.

Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ. Plenge P, et al. Among authors: shi l. J Biol Chem. 2012 Nov 16;287(47):39316-26. doi: 10.1074/jbc.M112.371765. Epub 2012 Sep 24. J Biol Chem. 2012. PMID: 23007398 Free PMC article.

39

Exploring Substrate Binding in the Extracellular Vestibule of MhsT by Atomistic Simulations and Markov Models.

Abramyan AM, Quick M, Xue C, Javitch JA, Shi L. Abramyan AM, et al. Among authors: shi l. J Chem Inf Model. 2018 Jun 25;58(6):1244-1252. doi: 10.1021/acs.jcim.8b00175. Epub 2018 Jun 11. J Chem Inf Model. 2018. PMID: 29851339 Free PMC article.

40

Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D₃ Dopamine Receptor.

Moritz AE, Bonifazi A, Guerrero AM, Kumar V, Free RB, Lane JR, Verma RK, Shi L, Newman AH, Sibley DR. Moritz AE, et al. Among authors: shi l. ACS Chem Neurosci. 2020 Oct 21;11(20):3309-3320. doi: 10.1021/acschemneuro.0c00425. Epub 2020 Oct 5. ACS Chem Neurosci. 2020. PMID: 32969645 Free PMC article.

41

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D₂/D₃ Receptor Bitopic Ligands.

Shaik AB, Boateng CA, Battiti FO, Bonifazi A, Cao J, Chen L, Chitsazi R, Ravi S, Lee KH, Shi L, Newman AH. Shaik AB, et al. Among authors: shi l. J Med Chem. 2021 Oct 28;64(20):15313-15333. doi: 10.1021/acs.jmedchem.1c01353. Epub 2021 Oct 12. J Med Chem. 2021. PMID: 34636551 Free PMC article.

42

Unraveling Activation-Related Rearrangements and Intrinsic Divergence from Ligand-Specific Conformational Changes of the Dopamine D3 and D2 Receptors.

Lee KH, Shi L. Lee KH, et al. Among authors: shi l. J Chem Inf Model. 2024 Mar 25;64(6):1778-1793. doi: 10.1021/acs.jcim.3c01956. Epub 2024 Mar 7. J Chem Inf Model. 2024. PMID: 38454785 Review.

43

A role for information collection, management, and integration in structure-function studies of G-protein coupled receptors.

Shi L, Javitch JA. Shi L, et al. Curr Pharm Des. 2006;12(14):1771-83. doi: 10.2174/138161206776873707. Curr Pharm Des. 2006. PMID: 16712487 Review.

44

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.

Lee KH, Fant AD, Guo J, Guan A, Jung J, Kudaibergenova M, Miranda WE, Ku T, Cao J, Wacker S, Duff HJ, Newman AH, Noskov SY, Shi L. Lee KH, et al. Among authors: shi l. J Chem Inf Model. 2021 Sep 27;61(9):4266-4279. doi: 10.1021/acs.jcim.1c00856. Epub 2021 Aug 21. J Chem Inf Model. 2021. PMID: 34420294 Free PMC article.

45

SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures.

Hao G, Derakhshan B, Shi L, Campagne F, Gross SS. Hao G, et al. Among authors: shi l. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1012-7. doi: 10.1073/pnas.0508412103. Epub 2006 Jan 17. Proc Natl Acad Sci U S A. 2006. PMID: 16418269 Free PMC article.

46

The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT.

Mondal S, Khelashvili G, Shi L, Weinstein H. Mondal S, et al. Among authors: shi l. Chem Phys Lipids. 2013 Apr;169:27-38. doi: 10.1016/j.chemphyslip.2013.01.006. Epub 2013 Jan 30. Chem Phys Lipids. 2013. PMID: 23376428 Free PMC article.

47

The binding sites for cocaine and dopamine in the dopamine transporter overlap.

Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. Beuming T, et al. Among authors: shi l. Nat Neurosci. 2008 Jul;11(7):780-9. doi: 10.1038/nn.2146. Epub 2008 Jun 22. Nat Neurosci. 2008. PMID: 18568020 Free PMC article.

48

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.

Okunola-Bakare OM, Cao J, Kopajtic T, Katz JL, Loland CJ, Shi L, Newman AH. Okunola-Bakare OM, et al. Among authors: shi l. J Med Chem. 2014 Feb 13;57(3):1000-13. doi: 10.1021/jm401754x. Epub 2014 Feb 4. J Med Chem. 2014. PMID: 24494745 Free PMC article.

49

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L. Stolzenberg S, et al. Among authors: shi l. J Biol Chem. 2015 May 29;290(22):13992-4003. doi: 10.1074/jbc.M114.625343. Epub 2015 Apr 13. J Biol Chem. 2015. PMID: 25869126 Free PMC article.

50

Identification of a putative binding site critical for general anesthetic activation of TRPA1.

Ton HT, Phan TX, Abramyan AM, Shi L, Ahern GP. Ton HT, et al. Among authors: shi l. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3762-3767. doi: 10.1073/pnas.1618144114. Epub 2017 Mar 20. Proc Natl Acad Sci U S A. 2017. PMID: 28320952 Free PMC article.

51

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

Carter M, Chen X, Slowinska B, Minnerath S, Glickstein S, Shi L, Campagne F, Weinstein H, Ross ME. Carter M, et al. Among authors: shi l. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12843-8. doi: 10.1073/pnas.0501963102. Epub 2005 Aug 26. Proc Natl Acad Sci U S A. 2005. PMID: 16126904 Free PMC article.

52

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.

Shi L, Quick M, Zhao Y, Weinstein H, Javitch JA. Shi L, et al. Mol Cell. 2008 Jun 20;30(6):667-77. doi: 10.1016/j.molcel.2008.05.008. Mol Cell. 2008. PMID: 18570870 Free PMC article.

53

Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor.

Yano H, Chitsazi R, Lucaj C, Tran P, Hoffman AF, Baumann MH, Lupica CR, Shi L. Yano H, et al. Among authors: shi l. ACS Chem Neurosci. 2023 Nov 1;14(21):3928-3940. doi: 10.1021/acschemneuro.3c00530. Epub 2023 Oct 17. ACS Chem Neurosci. 2023. PMID: 37847546 Free PMC article.

54

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Newman AH, et al. Among authors: shi l. J Med Chem. 2012 Aug 9;55(15):6689-99. doi: 10.1021/jm300482h. Epub 2012 Jun 7. J Med Chem. 2012. PMID: 22632094 Free PMC article.

55

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Michino M, Beuming T, Donthamsetti P, Newman AH, Javitch JA, Shi L. Michino M, et al. Among authors: shi l. Pharmacol Rev. 2015;67(1):198-213. doi: 10.1124/pr.114.009944. Pharmacol Rev. 2015. PMID: 25527701 Free PMC article. Review.

56

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.

Yano H, Bonifazi A, Xu M, Guthrie DA, Schneck SN, Abramyan AM, Fant AD, Hong WC, Newman AH, Shi L. Yano H, et al. Among authors: shi l. Neuropharmacology. 2018 May 1;133:264-275. doi: 10.1016/j.neuropharm.2018.01.042. Epub 2018 Jan 31. Neuropharmacology. 2018. PMID: 29407216 Free PMC article.

57

Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3.

Perry-Hauser NA, VanDyck MW, Lee KH, Shi L, Javitch JA. Perry-Hauser NA, et al. Among authors: shi l. J Biol Chem. 2022 Dec;298(12):102594. doi: 10.1016/j.jbc.2022.102594. Epub 2022 Oct 14. J Biol Chem. 2022. PMID: 36244455 Free PMC article.

58

In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling.

Tsai MM, Chen L, Baumann MH, Canals M, Javitch JA, Lane JR, Shi L. Tsai MM, et al. Among authors: shi l. ACS Chem Neurosci. 2024 Feb 21;15(4):854-867. doi: 10.1021/acschemneuro.3c00750. Epub 2024 Feb 12. ACS Chem Neurosci. 2024. PMID: 38345920

59

NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles.

Porcelli F, Verardi R, Shi L, Henzler-Wildman KA, Ramamoorthy A, Veglia G. Porcelli F, et al. Among authors: shi l. Biochemistry. 2008 May 20;47(20):5565-72. doi: 10.1021/bi702036s. Epub 2008 Apr 26. Biochemistry. 2008. PMID: 18439024 Free PMC article.

60

Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D₃ Dopamine Receptor Agonist.

Moritz AE, Free RB, Weiner WS, Akano EO, Gandhi D, Abramyan A, Keck TM, Ferrer M, Hu X, Southall N, Steiner J, Aubé J, Shi L, Frankowski KJ, Sibley DR. Moritz AE, et al. Among authors: shi l. J Med Chem. 2020 May 28;63(10):5526-5567. doi: 10.1021/acs.jmedchem.0c00424. Epub 2020 May 12. J Med Chem. 2020. PMID: 32342685 Free PMC article.

61

Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential.

Sibley DR, Luderman KD, Free RB, Shi L. Sibley DR, et al. Among authors: shi l. Signal Transduct Target Ther. 2021 May 22;6(1):205. doi: 10.1038/s41392-021-00630-3. Signal Transduct Target Ther. 2021. PMID: 34023856 Free PMC article. No abstract available.

62

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.

Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H. Khelashvili G, et al. Among authors: shi l. J Biol Chem. 2016 Sep 16;291(38):19786-99. doi: 10.1074/jbc.M116.731455. Epub 2016 Jul 29. J Biol Chem. 2016. PMID: 27474737 Free PMC article.

63

Structure and dynamics of a primordial catalytic fold generated by in vitro evolution.

Chao FA, Morelli A, Haugner JC 3rd, Churchfield L, Hagmann LN, Shi L, Masterson LR, Sarangi R, Veglia G, Seelig B. Chao FA, et al. Among authors: shi l. Nat Chem Biol. 2013 Feb;9(2):81-3. doi: 10.1038/nchembio.1138. Epub 2012 Dec 9. Nat Chem Biol. 2013. PMID: 23222886 Free PMC article.

64

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.

Klein Herenbrink C, Verma R, Lim HD, Kopinathan A, Keen A, Shonberg J, Draper-Joyce CJ, Scammells PJ, Christopoulos A, Javitch JA, Capuano B, Shi L, Lane JR. Klein Herenbrink C, et al. Among authors: shi l. ACS Chem Biol. 2019 Aug 16;14(8):1780-1792. doi: 10.1021/acschembio.9b00342. Epub 2019 Aug 5. ACS Chem Biol. 2019. PMID: 31339684 Free PMC article.

65

cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban.

Masterson LR, Yu T, Shi L, Wang Y, Gustavsson M, Mueller MM, Veglia G. Masterson LR, et al. Among authors: shi l. J Mol Biol. 2011 Sep 16;412(2):155-64. doi: 10.1016/j.jmb.2011.06.041. Epub 2011 Jul 2. J Mol Biol. 2011. PMID: 21741980 Free PMC article.

66

The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site.

Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H. Khelashvili G, et al. Among authors: shi l. J Am Chem Soc. 2013 Sep 25;135(38):14266-75. doi: 10.1021/ja405984v. Epub 2013 Sep 16. J Am Chem Soc. 2013. PMID: 23980525 Free PMC article.

67

Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors.

Singh PK, Fan H, Jiang X, Shi L, Nathan CF, Lin G. Singh PK, et al. Among authors: shi l. ChemMedChem. 2016 Oct 6;11(19):2127-2131. doi: 10.1002/cmdc.201600384. Epub 2016 Aug 25. ChemMedChem. 2016. PMID: 27561172 Free PMC article.

68

A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter.

Slack RD, Abramyan AM, Tang H, Meena S, Davis BA, Bonifazi A, Giancola JB, Deschamps JR, Naing S, Yano H, Singh SK, Newman AH, Shi L. Slack RD, et al. Among authors: shi l. ACS Chem Neurosci. 2019 Sep 18;10(9):3946-3952. doi: 10.1021/acschemneuro.9b00375. Epub 2019 Aug 22. ACS Chem Neurosci. 2019. PMID: 31424193 Free PMC article.

69

A Novel "Activation Switch" Motif Common to All Aminergic Receptors.

Lee KH, Manning JJ, Javitch J, Shi L. Lee KH, et al. Among authors: shi l. J Chem Inf Model. 2023 Aug 28;63(16):5001-5017. doi: 10.1021/acs.jcim.3c00732. Epub 2023 Aug 4. J Chem Inf Model. 2023. PMID: 37540602 Review.

70

The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation.

Abramyan AM, Stolzenberg S, Li Z, Loland CJ, Noé F, Shi L. Abramyan AM, et al. Among authors: shi l. ACS Chem Neurosci. 2017 Aug 16;8(8):1735-1746. doi: 10.1021/acschemneuro.7b00094. Epub 2017 May 4. ACS Chem Neurosci. 2017. PMID: 28441487

71

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.

Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC. Chien EY, et al. Among authors: shi l. Science. 2010 Nov 19;330(6007):1091-5. doi: 10.1126/science.1197410. Science. 2010. PMID: 21097933 Free PMC article.

72

Transition metal ion FRET uncovers K⁺ regulation of a neurotransmitter/sodium symporter.

Billesbølle CB, Mortensen JS, Sohail A, Schmidt SG, Shi L, Sitte HH, Gether U, Loland CJ. Billesbølle CB, et al. Among authors: shi l. Nat Commun. 2016 Sep 28;7:12755. doi: 10.1038/ncomms12755. Nat Commun. 2016. PMID: 27678200 Free PMC article.

73

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D₃ Receptor.

Michino M, Boateng CA, Donthamsetti P, Yano H, Bakare OM, Bonifazi A, Ellenberger MP, Keck TM, Kumar V, Zhu C, Verma R, Deschamps JR, Javitch JA, Newman AH, Shi L. Michino M, et al. Among authors: shi l. J Med Chem. 2017 Jan 26;60(2):580-593. doi: 10.1021/acs.jmedchem.6b01148. Epub 2017 Jan 5. J Med Chem. 2017. PMID: 27983845 Free PMC article.

74

Ion and pH Sensitivity of a TMBIM Ca²⁺ Channel.

Guo G, Xu M, Chang Y, Luyten T, Seitaj B, Liu W, Zhu P, Bultynck G, Shi L, Quick M, Liu Q. Guo G, et al. Among authors: shi l. Structure. 2019 Jun 4;27(6):1013-1021.e3. doi: 10.1016/j.str.2019.03.003. Epub 2019 Mar 28. Structure. 2019. PMID: 30930064 Free PMC article.

75

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.

Okorom AV, Camacho-Hernandez GA, Salomon K, Lee KH, Ku TC, Cao J, Won SJ, Friedman J, Lam J, Paule J, Rais R, Klein B, Xi ZX, Shi L, Loland CJ, Newman AH. Okorom AV, et al. Among authors: shi l. J Med Chem. 2024 Jan 11;67(1):709-727. doi: 10.1021/acs.jmedchem.3c02037. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117239

76

Identification and Characterization of ML321: A Novel and Highly Selective D₂ Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity.

Free RB, Nilson AN, Boldizsar NM, Doyle TB, Rodriguiz RM, Pogorelov VM, Machino M, Lee KH, Bertz JW, Xu J, Lim HD, Dulcey AE, Mach RH, Woods JH, Lane JR, Shi L, Marugan JJ, Wetsel WC, Sibley DR. Free RB, et al. Among authors: shi l. ACS Pharmacol Transl Sci. 2022 Dec 30;6(1):151-170. doi: 10.1021/acsptsci.2c00202. eCollection 2023 Jan 13. ACS Pharmacol Transl Sci. 2022. PMID: 36654757 Free PMC article.

77

Backbone NMR resonance assignment of the catalytic subunit of cAMP-dependent protein kinase A in complex with AMP-PNP.

Masterson LR, Shi L, Tonelli M, Mascioni A, Mueller MM, Veglia G. Masterson LR, et al. Among authors: shi l. Biomol NMR Assign. 2009 Jun;3(1):115-7. doi: 10.1007/s12104-009-9154-8. Epub 2009 Apr 12. Biomol NMR Assign. 2009. PMID: 19636960 Free PMC article.

78

Single-molecule dynamics of gating in a neurotransmitter transporter homologue.

Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. Zhao Y, et al. Among authors: shi l. Nature. 2010 May 13;465(7295):188-93. doi: 10.1038/nature09057. Nature. 2010. PMID: 20463731 Free PMC article.

79

Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics.

Abramyan AM, Slack RD, Meena S, Davis BA, Newman AH, Singh SK, Shi L. Abramyan AM, et al. Among authors: shi l. Neuropharmacology. 2019 Dec 15;161:107411. doi: 10.1016/j.neuropharm.2018.10.040. Epub 2018 Nov 1. Neuropharmacology. 2019. PMID: 30391505 Free PMC article.

80

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy.

Masterson LR, Shi L, Metcalfe E, Gao J, Taylor SS, Veglia G. Masterson LR, et al. Among authors: shi l. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6969-74. doi: 10.1073/pnas.1102701108. Epub 2011 Apr 6. Proc Natl Acad Sci U S A. 2011. PMID: 21471451 Free PMC article.

81

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

Zou MF, Cao J, Abramyan AM, Kopajtic T, Zanettini C, Guthrie DA, Rais R, Slusher BS, Shi L, Loland CJ, Newman AH. Zou MF, et al. Among authors: shi l. J Med Chem. 2017 Dec 28;60(24):10172-10187. doi: 10.1021/acs.jmedchem.7b01454. Epub 2017 Dec 11. J Med Chem. 2017. PMID: 29227643 Free PMC article.

82

Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders.

Newman AH, Cao J, Keighron JD, Jordan CJ, Bi GH, Liang Y, Abramyan AM, Avelar AJ, Tschumi CW, Beckstead MJ, Shi L, Tanda G, Xi ZX. Newman AH, et al. Among authors: shi l. Neuropsychopharmacology. 2019 Jul;44(8):1435-1444. doi: 10.1038/s41386-019-0366-z. Epub 2019 Mar 11. Neuropsychopharmacology. 2019. PMID: 30858517 Free PMC article.

83

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D₁ receptor.

Yano H, Cai NS, Xu M, Verma RK, Rea W, Hoffman AF, Shi L, Javitch JA, Bonci A, Ferré S. Yano H, et al. Among authors: shi l. Nat Commun. 2018 Feb 5;9(1):486. doi: 10.1038/s41467-017-02606-w. Nat Commun. 2018. PMID: 29402888 Free PMC article.

84

High-potency ligands for DREADD imaging and activation in rodents and monkeys.

Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. Bonaventura J, et al. Among authors: shi l. Nat Commun. 2019 Oct 11;10(1):4627. doi: 10.1038/s41467-019-12236-z. Nat Commun. 2019. PMID: 31604917 Free PMC article.

85

The sodium/multivitamin transporter: a multipotent system with therapeutic implications.

Quick M, Shi L. Quick M, et al. Among authors: shi l. Vitam Horm. 2015;98:63-100. doi: 10.1016/bs.vh.2014.12.003. Epub 2015 Mar 7. Vitam Horm. 2015. PMID: 25817866 Free PMC article. Review.

86

Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers.

Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A. Verardi R, et al. Among authors: shi l. Biochim Biophys Acta. 2011 Jan;1808(1):34-40. doi: 10.1016/j.bbamem.2010.08.008. Epub 2010 Aug 16. Biochim Biophys Acta. 2011. PMID: 20719234 Free PMC article.

87

Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response.

Palma M, Zurita J, Ferreras JA, Worgall S, Larone DH, Shi L, Campagne F, Quadri LE. Palma M, et al. Among authors: shi l. Infect Immun. 2005 May;73(5):2958-66. doi: 10.1128/IAI.73.5.2958-2966.2005. Infect Immun. 2005. PMID: 15845502 Free PMC article.

88

R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse.

Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, Kopajtic T, Shi L, Katz JL, Tanda G, Newman AH. Loland CJ, et al. Among authors: shi l. Biol Psychiatry. 2012 Sep 1;72(5):405-13. doi: 10.1016/j.biopsych.2012.03.022. Epub 2012 Apr 25. Biol Psychiatry. 2012. PMID: 22537794 Free PMC article.

89

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.

Henderson MJ, Trychta KA, Yang SM, Bäck S, Yasgar A, Wires ES, Danchik C, Yan X, Yano H, Shi L, Wu KJ, Wang AQ, Tao D, Zahoránszky-Kőhalmi G, Hu X, Xu X, Maloney D, Zakharov AV, Rai G, Urano F, Airavaara M, Gavrilova O, Jadhav A, Wang Y, Simeonov A, Harvey BK. Henderson MJ, et al. Among authors: shi l. Cell Rep. 2021 Apr 27;35(4):109040. doi: 10.1016/j.celrep.2021.109040. Cell Rep. 2021. PMID: 33910017 Free PMC article.

90

Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.

Ku TC, Cao J, Won SJ, Guo J, Camacho-Hernandez GA, Okorom AV, Salomon KW, Lee KH, Loland CJ, Duff HJ, Shi L, Newman AH. Ku TC, et al. Among authors: shi l. ACS Pharmacol Transl Sci. 2024 Jan 5;7(2):515-532. doi: 10.1021/acsptsci.3c00322. eCollection 2024 Feb 9. ACS Pharmacol Transl Sci. 2024. PMID: 38357284

91

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity.

Sanchez-Soto M, Verma RK, Willette BKA, Gonye EC, Moore AM, Moritz AE, Boateng CA, Yano H, Free RB, Shi L, Sibley DR. Sanchez-Soto M, et al. Among authors: shi l. Sci Signal. 2020 Feb 4;13(617):eaaw5885. doi: 10.1126/scisignal.aaw5885. Sci Signal. 2020. PMID: 32019899 Free PMC article.

92

Mechanistic Insights into Rare-Earth-Catalyzed Alternating Copolymerization through C-H Polyaddition of Functionalized Organic Compounds to Unconjugated Dienes.

Shi L, Zhang N, Xue Z, Luo G. Shi L, et al. Inorg Chem. 2024 Apr 25. doi: 10.1021/acs.inorgchem.4c00097. Online ahead of print. Inorg Chem. 2024. PMID: 38663005

93

Co-assembled Nanoparticles Towards Multi-target Combinational Therapy of Alzheimer's Disease by Making Full Use of Molecular Recognition and Self-assembly.

Li WB, Xu LL, Wang SL, Wang YY, Pan YC, Shi LQ, Guo DS. Li WB, et al. Among authors: shi lq. Adv Mater. 2024 Apr 25:e2401918. doi: 10.1002/adma.202401918. Online ahead of print. Adv Mater. 2024. PMID: 38662940

94

Lrp13a and Lrp13b serve as vitellogenin receptors in the ovary of zebrafish†.

Liu Z, Zhang N, Wang C, Shi L, Hu Y, Wang Y, Li J. Liu Z, et al. Among authors: shi l. Biol Reprod. 2024 Apr 24:ioae040. doi: 10.1093/biolre/ioae040. Online ahead of print. Biol Reprod. 2024. PMID: 38660750

95

Genome-wide identification and expression analysis of the cryptochromes reveal the CsCRY1 role under low-light-stress in cucumber.

Cao H, Wang R, Zhao J, Shi L, Huang Y, Wu T, Zhang C. Cao H, et al. Among authors: shi l. Front Plant Sci. 2024 Apr 10;15:1371435. doi: 10.3389/fpls.2024.1371435. eCollection 2024. Front Plant Sci. 2024. PMID: 38660445 Free PMC article.

96

YOLOv8s-CGF: a lightweight model for wheat ear Fusarium head blight detection.

Yang C, Sun X, Wang J, Lv H, Dong P, Xi L, Shi L. Yang C, et al. Among authors: shi l. PeerJ Comput Sci. 2024 Mar 27;10:e1948. doi: 10.7717/peerj-cs.1948. eCollection 2024. PeerJ Comput Sci. 2024. PMID: 38660210 Free PMC article.

97

Gfi1 controls the formation of effector CD8 T cells during chronic infection and cancer.

Ojo OA, Shen H, Ingram JT, Bonner JA, Welner RS, Lacaud G, Zajac AJ, Shi LZ. Ojo OA, et al. Among authors: shi lz. bioRxiv [Preprint]. 2024 Apr 21:2024.04.18.579535. doi: 10.1101/2024.04.18.579535. bioRxiv. 2024. PMID: 38659890 Free PMC article. Preprint.

98

Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.

Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X. Li Y, et al. Among authors: shi l. Cell Metab. 2024 Apr 16:S1550-4131(24)00118-9. doi: 10.1016/j.cmet.2024.03.014. Online ahead of print. Cell Metab. 2024. PMID: 38657612

99

Crown Ether Electrolyte Induced Li2O2 Amorphization for Low Polarization and Long Lifespan Li-O2 batteries.

Li M, Wu J, You Z, Dai Z, Gu Y, Shi L, Wu M, Wen Z. Li M, et al. Among authors: shi l. Angew Chem Int Ed Engl. 2024 Apr 24:e202403521. doi: 10.1002/anie.202403521. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 38654696

100

Novel anthropometric indicators of visceral obesity predict the severity of hyperlipidemic acute pancreatitis.

Zhu Y, Huang Y, Sun H, Chen L, Yu H, Shi L, Xia W, Sun X, Yang Y, Huang H. Zhu Y, et al. Among authors: shi l. Lipids Health Dis. 2024 Apr 23;23(1):120. doi: 10.1186/s12944-024-02112-1. Lipids Health Dis. 2024. PMID: 38654370

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