Whittaker DG - Search Results

1

Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243.

Kemp JM, Whittaker DG, Venkateshappa R, Pang Z, Johal R, Sergeev V, Tibbits GF, Mirams GR, Claydon TW. Kemp JM, et al. Among authors: whittaker dg. J Gen Physiol. 2021 Oct 4;153(10):e202112923. doi: 10.1085/jgp.202112923. Epub 2021 Aug 16. J Gen Physiol. 2021. PMID: 34398210 Free PMC article.

2

Calibration of ionic and cellular cardiac electrophysiology models.

Whittaker DG, Clerx M, Lei CL, Christini DJ, Mirams GR. Whittaker DG, et al. Wiley Interdiscip Rev Syst Biol Med. 2020 Jul;12(4):e1482. doi: 10.1002/wsbm.1482. Epub 2020 Feb 21. Wiley Interdiscip Rev Syst Biol Med. 2020. PMID: 32084308 Free PMC article. Review.

3

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments.

Lei CL, Clerx M, Whittaker DG, Gavaghan DJ, de Boer TP, Mirams GR. Lei CL, et al. Among authors: whittaker dg. Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190348. doi: 10.1098/rsta.2019.0348. Epub 2020 May 25. Philos Trans A Math Phys Eng Sci. 2020. PMID: 32448060 Free PMC article.

4

Considering discrepancy when calibrating a mechanistic electrophysiology model.

Lei CL, Ghosh S, Whittaker DG, Aboelkassem Y, Beattie KA, Cantwell CD, Delhaas T, Houston C, Novaes GM, Panfilov AV, Pathmanathan P, Riabiz M, Dos Santos RW, Walmsley J, Worden K, Mirams GR, Wilkinson RD. Lei CL, et al. Among authors: whittaker dg. Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190349. doi: 10.1098/rsta.2019.0349. Epub 2020 May 25. Philos Trans A Math Phys Eng Sci. 2020. PMID: 32448065 Free PMC article.

5

Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine.

Whittaker DG, Capel RA, Hendrix M, Chan XHS, Herring N, White NJ, Mirams GR, Burton RB. Whittaker DG, et al. R Soc Open Sci. 2021 Apr 13;8(4):210235. doi: 10.1098/rsos.210235. R Soc Open Sci. 2021. PMID: 33996135 Free PMC article.

6

A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer.

Lei CL, Fabbri A, Whittaker DG, Clerx M, Windley MJ, Hill AP, Mirams GR, de Boer TP. Lei CL, et al. Among authors: whittaker dg. Wellcome Open Res. 2021 Nov 2;5:152. doi: 10.12688/wellcomeopenres.15968.2. eCollection 2020. Wellcome Open Res. 2021. PMID: 34805549 Free PMC article.

7

A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models.

Barral YHM, Shuttleworth JG, Clerx M, Whittaker DG, Wang K, Polonchuk L, Gavaghan DJ, Mirams GR. Barral YHM, et al. Among authors: whittaker dg. Front Physiol. 2022 Apr 26;13:879035. doi: 10.3389/fphys.2022.879035. eCollection 2022. Front Physiol. 2022. PMID: 35557969 Free PMC article.

8

Ion channel model reduction using manifold boundaries.

Whittaker DG, Wang J, Shuttleworth JG, Venkateshappa R, Kemp JM, Claydon TW, Mirams GR. Whittaker DG, et al. J R Soc Interface. 2022 Aug;19(193):20220193. doi: 10.1098/rsif.2022.0193. Epub 2022 Aug 10. J R Soc Interface. 2022. PMID: 35946166 Free PMC article.

9

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk.

Lei CL, Whittaker DG, Mirams GR. Lei CL, et al. Among authors: whittaker dg. Br J Pharmacol. 2024 Apr;181(7):987-1004. doi: 10.1111/bph.16250. Epub 2023 Nov 8. Br J Pharmacol. 2024. PMID: 37740435

10

Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics.

Shuttleworth JG, Lei CL, Whittaker DG, Windley MJ, Hill AP, Preston SP, Mirams GR. Shuttleworth JG, et al. Among authors: whittaker dg. Bull Math Biol. 2023 Nov 24;86(1):2. doi: 10.1007/s11538-023-01224-6. Bull Math Biol. 2023. PMID: 37999811 Free PMC article.

11

Emerging therapeutic targets in the short QT syndrome.

Hancox JC, Whittaker DG, Du C, Stuart AG, Zhang H. Hancox JC, et al. Among authors: whittaker dg. Expert Opin Ther Targets. 2018 May;22(5):439-451. doi: 10.1080/14728222.2018.1470621. Expert Opin Ther Targets. 2018. PMID: 29697308 Free article. Review.

12

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome.

Whittaker DG, Hancox JC, Zhang H. Whittaker DG, et al. Front Physiol. 2019 Jan 11;9:1888. doi: 10.3389/fphys.2018.01888. eCollection 2018. Front Physiol. 2019. PMID: 30687112 Free PMC article.

13

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles.

Whittaker DG, Ni H, Benson AP, Hancox JC, Zhang H. Whittaker DG, et al. Front Physiol. 2017 Oct 4;8:759. doi: 10.3389/fphys.2017.00759. eCollection 2017. Front Physiol. 2017. PMID: 29085299 Free PMC article.

14

In silico investigation of a KCNQ1 mutation associated with short QT syndrome.

Adeniran I, Whittaker DG, El Harchi A, Hancox JC, Zhang H. Adeniran I, et al. Among authors: whittaker dg. Sci Rep. 2017 Aug 16;7(1):8469. doi: 10.1038/s41598-017-08367-2. Sci Rep. 2017. PMID: 28814790 Free PMC article.

15

Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin.

Ni H, Whittaker DG, Wang W, Giles WR, Narayan SM, Zhang H. Ni H, et al. Among authors: whittaker dg. Front Physiol. 2017 Nov 23;8:946. doi: 10.3389/fphys.2017.00946. eCollection 2017. Front Physiol. 2017. PMID: 29218016 Free PMC article.

16

Investigation of the Role of Myocyte Orientations in Cardiac Arrhythmia Using Image-Based Models.

Whittaker DG, Benson AP, Teh I, Schneider JE, Colman MA. Whittaker DG, et al. Biophys J. 2019 Dec 17;117(12):2396-2408. doi: 10.1016/j.bpj.2019.09.041. Epub 2019 Oct 8. Biophys J. 2019. PMID: 31679763 Free PMC article.

17

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study.

Alghamdi AM, Testrow CP, Whittaker DG, Boyett MR, Hancox JC, Zhang H. Alghamdi AM, et al. Among authors: whittaker dg. Front Physiol. 2020 Nov 20;11:547577. doi: 10.3389/fphys.2020.547577. eCollection 2020. Front Physiol. 2020. PMID: 33329016 Free PMC article.

18

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling.

Whittaker DG, Colman MA, Ni H, Hancox JC, Zhang H. Whittaker DG, et al. Front Physiol. 2018 Oct 4;9:1402. doi: 10.3389/fphys.2018.01402. eCollection 2018. Front Physiol. 2018. PMID: 30337886 Free PMC article.

19

Multi-scale approaches for the simulation of cardiac electrophysiology: II - Tissue-level structure and function.

Benson AP, Stevenson-Cocks HJ, Whittaker DG, White E, Colman MA. Benson AP, et al. Among authors: whittaker dg. Methods. 2021 Jan;185:60-81. doi: 10.1016/j.ymeth.2020.01.010. Epub 2020 Jan 25. Methods. 2021. PMID: 31988002 Free article. Review.

20

Multi-scale approaches for the simulation of cardiac electrophysiology: I - Sub-cellular and stochastic calcium dynamics from cell to organ.

Colman MA, Holmes M, Whittaker DG, Jayasinghe I, Benson AP. Colman MA, et al. Among authors: whittaker dg. Methods. 2021 Jan;185:49-59. doi: 10.1016/j.ymeth.2020.02.011. Epub 2020 Feb 29. Methods. 2021. PMID: 32126258 Review.

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