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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.
Ghovanloo MR, Choudhury K, Bandaru TS, Fouda MA, Rayani K, Rusinova R, Phaterpekar T, Nelkenbrecher K, Watkins AR, Poburko D, Thewalt J, Andersen OS, Delemotte L, Goodchild SJ, Ruben PC. Ghovanloo MR, et al. Among authors: delemotte l. J Gen Physiol. 2021 May 3;153(5):e202012701. doi: 10.1085/jgp.202012701. J Gen Physiol. 2021. PMID: 33836525 Free PMC article.
Gating Pore Currents in Sodium Channels.
Groome JR, Moreau A, Delemotte L. Groome JR, et al. Among authors: delemotte l. Handb Exp Pharmacol. 2018;246:371-399. doi: 10.1007/164_2017_54. Handb Exp Pharmacol. 2018. PMID: 28965172 Review.
Gating pore currents and the resting state of Nav1.4 voltage sensor domains.
Gosselin-Badaroudine P, Delemotte L, Moreau A, Klein ML, Chahine M. Gosselin-Badaroudine P, et al. Among authors: delemotte l. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19250-5. doi: 10.1073/pnas.1217990109. Epub 2012 Nov 7. Proc Natl Acad Sci U S A. 2012. PMID: 23134726 Free PMC article.
Ion Channels: Intersection of Structure, Function, and Pharmacology.
Moiseenkova-Bell V, Delemotte L, Minor DL Jr. Moiseenkova-Bell V, et al. Among authors: delemotte l. J Mol Biol. 2021 Aug 20;433(17):167102. doi: 10.1016/j.jmb.2021.167102. Epub 2021 Jun 11. J Mol Biol. 2021. PMID: 34119491 No abstract available.
Molecular Dynamics Simulations of Ion Channels.
Carnevale V, Delemotte L, Howard RJ. Carnevale V, et al. Among authors: delemotte l. Trends Biochem Sci. 2021 Jul;46(7):621-622. doi: 10.1016/j.tibs.2021.04.005. Epub 2021 Apr 30. Trends Biochem Sci. 2021. PMID: 33941431 Free article. No abstract available.
75 results