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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.
Ghovanloo MR, Choudhury K, Bandaru TS, Fouda MA, Rayani K, Rusinova R, Phaterpekar T, Nelkenbrecher K, Watkins AR, Poburko D, Thewalt J, Andersen OS, Delemotte L, Goodchild SJ, Ruben PC. Ghovanloo MR, et al. Among authors: ruben pc. J Gen Physiol. 2021 May 3;153(5):e202012701. doi: 10.1085/jgp.202012701. J Gen Physiol. 2021. PMID: 33836525 Free PMC article.
Introduction to sodium channels.
Peters CH, Ruben PC. Peters CH, et al. Among authors: ruben pc. Handb Exp Pharmacol. 2014;221:1-6. doi: 10.1007/978-3-642-41588-3_1. Handb Exp Pharmacol. 2014. PMID: 24737229 Review.
Physiology and Pathophysiology of Sodium Channel Inactivation.
Ghovanloo MR, Aimar K, Ghadiry-Tavi R, Yu A, Ruben PC. Ghovanloo MR, et al. Among authors: ruben pc. Curr Top Membr. 2016;78:479-509. doi: 10.1016/bs.ctm.2016.04.001. Epub 2016 Jul 5. Curr Top Membr. 2016. PMID: 27586293 Review.
Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants.
Abdelsayed M, Baruteau AE, Gibbs K, Sanatani S, Krahn AD, Probst V, Ruben PC. Abdelsayed M, et al. Among authors: ruben pc. J Physiol. 2017 Sep 15;595(18):6165-6186. doi: 10.1113/JP274536. Epub 2017 Aug 20. J Physiol. 2017. PMID: 28734073 Free PMC article.
pH Modulation of Voltage-Gated Sodium Channels.
Peters CH, Ghovanloo MR, Gershome C, Ruben PC. Peters CH, et al. Among authors: ruben pc. Handb Exp Pharmacol. 2018;246:147-160. doi: 10.1007/164_2018_99. Handb Exp Pharmacol. 2018. PMID: 29460150 Review.
Inhibitory effects of cannabidiol on voltage-dependent sodium currents.
Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Ghovanloo MR, et al. Among authors: ruben pc. J Biol Chem. 2018 Oct 26;293(43):16546-16558. doi: 10.1074/jbc.RA118.004929. Epub 2018 Sep 14. J Biol Chem. 2018. PMID: 30219789 Free PMC article.
93 results