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Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control.
Salpini R, Alkhatib M, Costa G, Piermatteo L, Ambrosio FA, Di Maio VC, Scutari R, Duca L, Berno G, Fabeni L, Alcaro S, Ceccherini-Silberstein F, Artese A, Svicher V. Salpini R, et al. Among authors: ambrosio fa. J Antimicrob Chemother. 2021 Jan 19;76(2):396-412. doi: 10.1093/jac/dkaa444. J Antimicrob Chemother. 2021. PMID: 33254234 Free PMC article.
Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance.
Malet I, Ambrosio FA, Subra F, Herrmann B, Leh H, Bouger MC, Artese A, Katlama C, Talarico C, Romeo I, Alcaro S, Costa G, Deprez E, Calvez V, Marcelin AG, Delelis O. Malet I, et al. Among authors: ambrosio fa. J Antimicrob Chemother. 2018 May 1;73(5):1158-1166. doi: 10.1093/jac/dkx529. J Antimicrob Chemother. 2018. PMID: 29373677
New resistance mutations to nucleoside reverse transcriptase inhibitors at codon 184 of HIV-1 reverse transcriptase (M184L and M184T).
Pouga L, Santoro MM, Charpentier C, Di Carlo D, Romeo I, Artese A, Alcaro S, Antinori A, Wirden M, Perno CF, Ambrosio FA, Calvez V, Descamps D, Marcelin AG, Ceccherini-Silberstein F, Lambert-Niclot S. Pouga L, et al. Among authors: ambrosio fa. Chem Biol Drug Des. 2019 Jan;93(1):50-59. doi: 10.1111/cbdd.13378. Epub 2018 Nov 27. Chem Biol Drug Des. 2019. PMID: 30103267
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques.
Costa G, Rocca R, Corona A, Grandi N, Moraca F, Romeo I, Talarico C, Gagliardi MG, Ambrosio FA, Ortuso F, Alcaro S, Distinto S, Maccioni E, Tramontano E, Artese A. Costa G, et al. Among authors: ambrosio fa. Eur J Med Chem. 2019 Jan 1;161:1-10. doi: 10.1016/j.ejmech.2018.10.029. Epub 2018 Oct 13. Eur J Med Chem. 2019. PMID: 30342421
Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies.
Della Volpe S, Nasti R, Queirolo M, Unver MY, Jumde VK, Dömling A, Vasile F, Potenza D, Ambrosio FA, Costa G, Alcaro S, Zucal C, Provenzani A, Di Giacomo M, Rossi D, Hirsch AKH, Collina S. Della Volpe S, et al. Among authors: ambrosio fa. ACS Med Chem Lett. 2019 Jan 21;10(4):615-620. doi: 10.1021/acsmedchemlett.8b00600. eCollection 2019 Apr 11. ACS Med Chem Lett. 2019. PMID: 30996806 Free PMC article.
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.
Esposito F, Ambrosio FA, Maleddu R, Costa G, Rocca R, Maccioni E, Catalano R, Romeo I, Eleftheriou P, Karia DC, Tsirides P, Godvani N, Pandya H, Corona A, Alcaro S, Artese A, Geronikaki A, Tramontano E. Esposito F, et al. Among authors: ambrosio fa. Eur J Med Chem. 2019 Nov 15;182:111617. doi: 10.1016/j.ejmech.2019.111617. Epub 2019 Aug 12. Eur J Med Chem. 2019. PMID: 31442684
51 results