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Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ. Hayn M, et al. Among authors: conzelmann c, conzelmann kk. Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27. Cell Rep. 2021. PMID: 33974846 Free PMC article.
Spike residue 403 affects binding of coronavirus spikes to human ACE2.
Zech F, Schniertshauer D, Jung C, Herrmann A, Cordsmeier A, Xie Q, Nchioua R, Prelli Bozzo C, Volcic M, Koepke L, Müller JA, Krüger J, Heller S, Stenger S, Hoffmann M, Pöhlmann S, Kleger A, Jacob T, Conzelmann KK, Ensser A, Sparrer KMJ, Kirchhoff F. Zech F, et al. Among authors: conzelmann kk. Nat Commun. 2021 Nov 25;12(1):6855. doi: 10.1038/s41467-021-27180-0. Nat Commun. 2021. PMID: 34824253 Free PMC article.
Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.
Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D. Braun E, et al. Among authors: conzelmann kk. Cell Rep. 2019 May 14;27(7):2092-2104.e10. doi: 10.1016/j.celrep.2019.04.063. Cell Rep. 2019. PMID: 31091448 Free article.
Cell-penetrating and neurotargeting dendritic siRNA nanostructures.
Brunner K, Harder J, Halbach T, Willibald J, Spada F, Gnerlich F, Sparrer K, Beil A, Möckl L, Bräuchle C, Conzelmann KK, Carell T. Brunner K, et al. Among authors: conzelmann kk. Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1946-9. doi: 10.1002/anie.201409803. Epub 2014 Dec 17. Angew Chem Int Ed Engl. 2015. PMID: 25522332
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.
Cui S, Eisenächer K, Kirchhofer A, Brzózka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP. Cui S, et al. Among authors: conzelmann kk. Mol Cell. 2008 Feb 1;29(2):169-79. doi: 10.1016/j.molcel.2007.10.032. Mol Cell. 2008. PMID: 18243112 Free article.
Interferon in rabies virus infection.
Rieder M, Conzelmann KK. Rieder M, et al. Among authors: conzelmann kk. Adv Virus Res. 2011;79:91-114. doi: 10.1016/B978-0-12-387040-7.00006-8. Adv Virus Res. 2011. PMID: 21601044 Review.
131 results