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Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.
Lee JB, Zgair A, Malec J, Kim TH, Kim MG, Ali J, Qin C, Feng W, Chiang M, Gao X, Voronin G, Garces AE, Lau CL, Chan TH, Hume A, McIntosh TM, Soukarieh F, Al-Hayali M, Cipolla E, Collins HM, Heery DM, Shin BS, Yoo SD, Kagan L, Stocks MJ, Bradshaw TD, Fischer PM, Gershkovich P. Lee JB, et al. Among authors: feng w. J Control Release. 2018 Sep 28;286:10-19. doi: 10.1016/j.jconrel.2018.07.022. Epub 2018 Jul 18. J Control Release. 2018. PMID: 30016732 Free PMC article.
Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach.
Qin C, Chu Y, Feng W, Fromont C, He S, Ali J, Lee JB, Zgair A, Berton M, Bettonte S, Liu R, Yang L, Monmaturapoj T, Medrano-Padial C, Ugalde AAR, Vetrugno D, Ee SY, Sheriston C, Wu Y, Stocks MJ, Fischer PM, Gershkovich P. Qin C, et al. Among authors: feng w. J Control Release. 2021 Jan 10;329:1077-1089. doi: 10.1016/j.jconrel.2020.10.036. Epub 2020 Oct 20. J Control Release. 2021. PMID: 33091528
Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol.
Feng W, Qin C, Chu Y, Berton M, Lee JB, Zgair A, Bettonte S, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Eur J Pharm Biopharm. 2021 May;162:43-49. doi: 10.1016/j.ejpb.2021.02.013. Epub 2021 Mar 5. Eur J Pharm Biopharm. 2021. PMID: 33677067
Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-1 reservoir in mesenteric lymph nodes.
Chu Y, Qin C, Feng W, Sheriston C, Jane Khor Y, Medrano-Padial C, Watson BE, Chan T, Ling B, Stocks MJ, Fischer PM, Gershkovich P. Chu Y, et al. Among authors: feng w. Int J Pharm. 2021 Jun 1;602:120621. doi: 10.1016/j.ijpharm.2021.120621. Epub 2021 Apr 21. Int J Pharm. 2021. PMID: 33892057
Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle.
Feng W, Qin C, Cipolla E, Lee JB, Zgair A, Chu Y, Ortori CA, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Pharmaceutics. 2021 Aug 27;13(9):1349. doi: 10.3390/pharmaceutics13091349. Pharmaceutics. 2021. PMID: 34575426 Free PMC article.
6,439 results