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Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome.
Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, Villacorta L, Fan Y, Chang L, Wang L, Liu C, Yang D, Song J, Rech JC, Guo Y, Wang H, Zhao G, Liang W, Koike Y, Lu H, Koike T, Hayek T, Pennathur S, Xi C, Wen B, Sun D, Garcia-Barrio MT, Aviram M, Gottlieb E, Mor I, Liu W, Zhang J, Chen YE. Rom O, et al. Among authors: gottlieb e. Sci Transl Med. 2020 Dec 2;12(572):eaaz2841. doi: 10.1126/scitranslmed.aaz2841. Sci Transl Med. 2020. PMID: 33268508 Free PMC article.
Alcohol-derived acetate modulates brain function.
Ghrayeb A, Gottlieb E, Mor I. Ghrayeb A, et al. Among authors: gottlieb e. Nat Metab. 2019 Nov;1(11):1036-1037. doi: 10.1038/s42255-019-0139-3. Nat Metab. 2019. PMID: 32694859 No abstract available.
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.
Rom O, Liu Y, Finney AC, Ghrayeb A, Zhao Y, Shukha Y, Wang L, Rajanayake KK, Das S, Rashdan NA, Weissman N, Delgadillo L, Wen B, Garcia-Barrio MT, Aviram M, Kevil CG, Yurdagul A Jr, Pattillo CB, Zhang J, Sun D, Hayek T, Gottlieb E, Mor I, Chen YE. Rom O, et al. Among authors: gottlieb e. Redox Biol. 2022 Jun;52:102313. doi: 10.1016/j.redox.2022.102313. Epub 2022 Apr 13. Redox Biol. 2022. PMID: 35447412 Free PMC article.
Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen.
Ghrayeb A, Agranovich B, Peled D, Finney AC, Abramovich I, Garcia JF, Traylor J, Drucker S, Fernandes SI, Weissman N, Chen YE, Rom O, Mor I, Gottlieb E. Ghrayeb A, et al. Among authors: gottlieb e. bioRxiv [Preprint]. 2023 Jan 18:2023.01.16.524043. doi: 10.1101/2023.01.16.524043. bioRxiv. 2023. PMID: 36711913 Free PMC article. Preprint.
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.
Savino AM, Fernandes SI, Olivares O, Zemlyansky A, Cousins A, Markert EK, Barel S, Geron I, Frishman L, Birger Y, Eckert C, Tumanov S, MacKay G, Kamphorst JJ, Herzyk P, Fernández-García J, Abramovich I, Mor I, Bardini M, Barin E, Janaki-Raman S, Cross JR, Kharas MG, Gottlieb E, Izraeli S, Halsey C. Savino AM, et al. Among authors: gottlieb e. Nat Cancer. 2020 Oct;1(10):998-1009. doi: 10.1038/s43018-020-00115-2. Epub 2020 Sep 28. Nat Cancer. 2020. PMID: 33479702 Free PMC article.
SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.
Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N, Nahum L, Avivi MY, Roichman A, Kanfi Y, Gertler AA, Doniger T, Ilkayeva OR, Abramovich I, Yaron O, Lerrer B, Gottlieb E, Harris RA, Gerber D, Hirschey MD, Cohen HY. Naiman S, et al. Among authors: gottlieb e. Cell Rep. 2019 Dec 17;29(12):4127-4143.e8. doi: 10.1016/j.celrep.2019.11.067. Cell Rep. 2019. PMID: 31851938 Free PMC article.
Restraining colorectal cancer with αKG.
Krauß D, Gottlieb E. Krauß D, et al. Among authors: gottlieb e. Nat Cancer. 2020 Mar;1(3):267-269. doi: 10.1038/s43018-020-0044-4. Nat Cancer. 2020. PMID: 35122033 No abstract available.
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.
Casciano JC, Perry C, Cohen-Nowak AJ, Miller KD, Vande Voorde J, Zhang Q, Chalmers S, Sandison ME, Liu Q, Hedley A, McBryan T, Tang HY, Gorman N, Beer T, Speicher DW, Adams PD, Liu X, Schlegel R, McCarron JG, Wakelam MJO, Gottlieb E, Kossenkov AV, Schug ZT. Casciano JC, et al. Among authors: gottlieb e. Br J Cancer. 2020 Mar;122(6):868-884. doi: 10.1038/s41416-019-0711-3. Epub 2020 Jan 16. Br J Cancer. 2020. PMID: 31942031 Free PMC article.
Mind your media.
Lagziel S, Gottlieb E, Shlomi T. Lagziel S, et al. Among authors: gottlieb e. Nat Metab. 2020 Dec;2(12):1369-1372. doi: 10.1038/s42255-020-00299-y. Nat Metab. 2020. PMID: 33046912 No abstract available.
Targeting metabolic transformation for cancer therapy.
Tennant DA, Durán RV, Gottlieb E. Tennant DA, et al. Among authors: gottlieb e. Nat Rev Cancer. 2010 Apr;10(4):267-77. doi: 10.1038/nrc2817. Epub 2010 Mar 19. Nat Rev Cancer. 2010. PMID: 20300106 Review.
437 results