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1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
Pismataro MC, Felicetti T, Bertagnin C, Nizi MG, Bonomini A, Barreca ML, Cecchetti V, Jochmans D, De Jonghe S, Neyts J, Loregian A, Tabarrini O, Massari S. Pismataro MC, et al. Among authors: loregian a. Eur J Med Chem. 2021 Oct 5;221:113494. doi: 10.1016/j.ejmech.2021.113494. Epub 2021 Apr 26. Eur J Med Chem. 2021. PMID: 33962311
The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein.
Loregian A, Mercorelli B, Muratore G, Sinigalia E, Pagni S, Massari S, Gribaudo G, Gatto B, Palumbo M, Tabarrini O, Cecchetti V, Palù G. Loregian A, et al. Antimicrob Agents Chemother. 2010 May;54(5):1930-40. doi: 10.1128/AAC.01730-09. Epub 2010 Mar 1. Antimicrob Agents Chemother. 2010. PMID: 20194695 Free PMC article.
The 6-Aminoquinolone WC5 inhibits different functions of the immediate-early 2 (IE2) protein of human cytomegalovirus that are essential for viral replication.
Mercorelli B, Luganini A, Muratore G, Massari S, Terlizzi ME, Tabarrini O, Gribaudo G, Palù G, Loregian A. Mercorelli B, et al. Among authors: loregian a. Antimicrob Agents Chemother. 2014 Nov;58(11):6615-26. doi: 10.1128/AAC.03309-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155603 Free PMC article.
108 results