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A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3.
Bhagwani AR, Ali M, Piper B, Liu M, Hudson J, Kelly N, Bogamuwa S, Yang H, Londino JD, Bednash JS, Farkas D, Mallampalli RK, Nicolls MR, Ryan JJ, Thompson AAR, Chan SY, Gomez D, Goncharova EA, Farkas L. Bhagwani AR, et al. Among authors: mallampalli rk. iScience. 2023 Jan 5;26(2):105935. doi: 10.1016/j.isci.2023.105935. eCollection 2023 Feb 17. iScience. 2023. PMID: 36685041 Free PMC article.
Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2.
Bednash JS, Johns F, Farkas D, Elhance A, Adair J, Cress K, Yount JS, Kenney AD, Londino JD, Mallampalli RK. Bednash JS, et al. Among authors: mallampalli rk. Am J Respir Cell Mol Biol. 2023 May;68(5):566-576. doi: 10.1165/rcmb.2022-0331OC. Am J Respir Cell Mol Biol. 2023. PMID: 36730646 Free PMC article.
RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension.
Piper B, Bogamuwa S, Hossain T, Farkas D, Rosas L, Green AC, Newcomb G, Sun N, Ovando-Ricardez JA, Horowitz JC, Bhagwani AR, Yang H, Kudryashova TV, Rojas M, Mora AL, Yan P, Mallampalli RK, Goncharova EA, Eckmann DM, Farkas L. Piper B, et al. Among authors: mallampalli rk. J Clin Invest. 2024 Feb 1;134(3):e169441. doi: 10.1172/JCI169441. J Clin Invest. 2024. PMID: 38015641 Free PMC article.
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O'Donnell CP, Finkel T, Chen BB, Mallampalli RK. Liu Y, et al. Among authors: mallampalli rk. Nat Chem Biol. 2021 Mar;17(3):298-306. doi: 10.1038/s41589-020-00723-0. Epub 2021 Jan 25. Nat Chem Biol. 2021. PMID: 33495648 Free PMC article.
ISGylation of NF-κBp65 by SCFFBXL19 E3 Ligase Diminishes Endothelial Inflammation.
Li L, Miao J, Shaheen N, Taleb SJ, Hu J, Ye Q, He J, Yan J, Mallampalli RK, Zhao J, Zhao Y. Li L, et al. Among authors: mallampalli rk. Arterioscler Thromb Vasc Biol. 2023 May;43(5):674-683. doi: 10.1161/ATVBAHA.122.318894. Epub 2023 Mar 30. Arterioscler Thromb Vasc Biol. 2023. PMID: 36994728 Free PMC article.
187 results