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Senolytics reduce coronavirus-related mortality in old mice.
Science. 2021 Jul 16;373(6552):eabe4832. doi: 10.1126/science.abe4832. Epub 2021 Jun 8.
Science. 2021.
PMID: 34103349
Free PMC article.
Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model.
Grange C, Papadimitriou E, Dimuccio V, Pastorino C, Molina J, O'Kelly R, Niedernhofer LJ, Robbins PD, Camussi G, Bussolati B.
Grange C, et al.
Mol Ther. 2020 Feb 5;28(2):490-502. doi: 10.1016/j.ymthe.2019.11.013. Epub 2019 Nov 18.
Mol Ther. 2020.
PMID: 31818691
Free PMC article.
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ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD.
Zhao J, et al.
Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22.
Aging (Albany NY). 2020.
PMID: 32201398
Free PMC article.
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An aged immune system drives senescence and ageing of solid organs.
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ.
Yousefzadeh MJ, et al. Among authors: o kelly rd.
Nature. 2021 Jun;594(7861):100-105. doi: 10.1038/s41586-021-03547-7. Epub 2021 May 12.
Nature. 2021.
PMID: 33981041
Free PMC article.
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Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging.
Zhang L, Zhao J, Mu X, McGowan SJ, Angelini L, O'Kelly RD, Yousefzadeh MJ, Sakamoto A, Aversa Z, LeBrasseur NK, Suh Y, Huard J, Kamenecka TM, Niedernhofer LJ, Robbins PD.
Zhang L, et al. Among authors: o kelly rd.
Aging Cell. 2021 Dec;20(12):e13486. doi: 10.1111/acel.13486. Epub 2021 Nov 3.
Aging Cell. 2021.
PMID: 34734460
Free PMC article.
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Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy.
Henpita C, Vyas R, Healy CL, Kieu TL, Gurkar AU, Yousefzadeh MJ, Cui Y, Lu A, Angelini LA, O'Kelly RD, McGowan SJ, Chandrasekhar S, Vanderpool RR, Hennessy-Wack D, Ross MA, Bachman TN, McTiernan C, Pillai SPS, Ladiges W, Lavasani M, Huard J, Beer-Stolz D, St Croix CM, Watkins SC, Robbins PD, Mora AL, Kelley EE, Wang Y, O'Connell TD, Niedernhofer LJ.
Henpita C, et al. Among authors: o kelly rd.
Aging Cell. 2023 Apr;22(4):e13782. doi: 10.1111/acel.13782. Epub 2023 Feb 3.
Aging Cell. 2023.
PMID: 36734200
Free PMC article.
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Failure to repair endogenous DNA damage in β-cells causes adult-onset diabetes in mice.
Yousefzadeh MJ, Huerta Guevara AP, Postmus AC, Flores RR, Sano T, Jurdzinski A, Angelini L, McGowan SJ, O'Kelly RD, Wade EA, Gonzalez-Espada LV, Henessy-Wack D, Howard S, Rozgaja TA, Trussoni CE, LaRusso NF, Eggen BJL, Jonker JW, Robbins PD, Niedernhofer LJ, Kruit JK.
Yousefzadeh MJ, et al. Among authors: o kelly rd.
Aging Biol. 2023;1(1):20230015. doi: 10.59368/agingbio.20230015. Epub 2023 Oct 23.
Aging Biol. 2023.
PMID: 38124711
Free PMC article.
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