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An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
Liu Y, Soh WT, Kishikawa JI, Hirose M, Nakayama EE, Li S, Sasai M, Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley DM, Shioda T, Arase H. Liu Y, et al. Among authors: ohshima s. Cell. 2021 Jun 24;184(13):3452-3466.e18. doi: 10.1016/j.cell.2021.05.032. Epub 2021 May 24. Cell. 2021. PMID: 34139176 Free PMC article.
SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses.
Kohyama M, Suzuki T, Nakai W, Ono C, Matsuoka S, Iwatani K, Liu Y, Sakai Y, Nakagawa A, Tomii K, Ohmura K, Okada M, Matsuura Y, Ohshima S, Maeda Y, Okamoto T, Arase H. Kohyama M, et al. Among authors: ohshima s. Int Immunol. 2023 Jan 21;35(1):43-52. doi: 10.1093/intimm/dxac044. Int Immunol. 2023. PMID: 36053553 Free PMC article.
Long-term follow-up of the changes in circulating cytokines, soluble cytokine receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNF alpha antibody therapy.
Ohshima S, Saeki Y, Mima T, Sasai M, Nishioka K, Ishida H, Shimizu M, Suemura M, McCloskey R, Kishimoto T. Ohshima S, et al. J Clin Immunol. 1999 Sep;19(5):305-13. doi: 10.1023/a:1020543625282. J Clin Immunol. 1999. PMID: 10535607 Clinical Trial.
Tumour necrosis factor alpha (TNF-alpha) interferes with Fas-mediated apoptotic cell death on rheumatoid arthritis (RA) synovial cells: a possible mechanism of rheumatoid synovial hyperplasia and a clinical benefit of anti-TNF-alpha therapy for RA.
Ohshima S, Mima T, Sasai M, Nishioka K, Shimizu M, Murata N, Yoshikawa H, Nakanishi K, Suemura M, McCloskey RV, Kishimoto T, Saeki Y. Ohshima S, et al. Cytokine. 2000 Mar;12(3):281-8. doi: 10.1006/cyto.1999.0552. Cytokine. 2000. PMID: 10704256
Increased levels of plasma nucleotides in patients with rheumatoid arthritis.
Kishikawa T, Maeda Y, Nii T, Arase N, Hirata J, Suzuki K, Yamamoto K, Masuda T, Ogawa K, Tsuji S, Matsushita M, Matsuoka H, Yoshimura M, Tsunoda S, Ohshima S, Narazaki M, Ogata A, Saeki Y, Inohara H, Kumanogoh A, Takeda K, Okada Y. Kishikawa T, et al. Among authors: ohshima s. Int Immunol. 2021 Jan 28;33(2):119-124. doi: 10.1093/intimm/dxaa059. Int Immunol. 2021. PMID: 32866240 Free PMC article.
785 results