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Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.
Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alagpulinsa DA, et al. Among authors: sremac m. Am J Transplant. 2019 Jul;19(7):1930-1940. doi: 10.1111/ajt.15308. Epub 2019 Mar 25. Am J Transplant. 2019. PMID: 30748094 Free article.
Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression.
Chen T, Yuan J, Duncanson S, Hibert ML, Kodish BC, Mylavaganam G, Maker M, Li H, Sremac M, Santosuosso M, Forbes B, Kashiwagi S, Cao J, Lei J, Thomas M, Hartono C, Sachs D, Markmann J, Sambanis A, Poznansky MC. Chen T, et al. Among authors: sremac m. Am J Transplant. 2015 Mar;15(3):618-27. doi: 10.1111/ajt.13049. Am J Transplant. 2015. PMID: 25693473 Free article.