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Biallelic variants in CELSR1 cause brain malformations, neurodevelopmental disorders and epilepsy in humans.
Bonardi CM, Møller RS, Ruiz-Reig N, Chai G, Madsen CG, Bayat A, Hammer TB, Fenger CD, Gardella E, Gawlinski P, Dawidziuk M, Wiszniewski W, Bekiesinska-Figatowska M, Cabet S, Rossi M, Lesca G, Gouy E, Jepsen B, Mieszczanek TS, Sanchez Russo R, Barr EE, Õunap K, Ilves P, Wojcik MH, Aittaleb M, Brusgaard K, Tissir F, Rubboli G. Bonardi CM, et al. Among authors: tissir f. Nat Commun. 2026 Jan 13. doi: 10.1038/s41467-025-67576-w. Online ahead of print. Nat Commun. 2026. PMID: 41530147 Free article.
A Celsr3 Mutation Linked to Tourette Disorder Disrupts Cortical Dendritic Patterning and Striatal Cholinergic Interneuron Excitability.
Nasello C, Yilmaz GD, Poppi LA, Kowalski TF, Ho-Nguyen KT, Wu J, Matrongolo M, Thackray JK, Shi A, Carayannopoulos NL, Cheedalla N, McGinnis J, Chen J, Khondker A, Tissir F, Heiman GA, Tischfield JA, Tischfield MA. Nasello C, et al. Among authors: tissir f. Int J Mol Sci. 2025 Oct 23;26(21):10307. doi: 10.3390/ijms262110307. Int J Mol Sci. 2025. PMID: 41226347 Free PMC article.
Competing Programs Shape Cortical Sensorimotor-Association Axis Development.
Tsyporin J, Zhang M, Qi C, Segal A, Finn T, Kim H, Choi SH, Li X, Bandiera S, Pavlovic I, Kim SK, Shibata A, Onishi K, Zhang Z, Hammarlund E, Su G, Salla N, Kachko J, Hawley C, Li S, Doyle DZ, Peng X, Nottoli T, Ruiz-Reig N, Tissir F, Nakagawa Y, Herzog E, Ma S, Gobeske K, Pattabiraman K, Shimogori T, Duque A, Fornito A, Huang H, Shibata M, Chen B, Sestan N. Tsyporin J, et al. Among authors: tissir f. bioRxiv [Preprint]. 2025 Jun 27:2025.06.26.660775. doi: 10.1101/2025.06.26.660775. bioRxiv. 2025. PMID: 40666864 Free PMC article. Preprint.
Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice.
Nasello C, Poppi LA, Wu J, Kowalski TF, Thackray JK, Wang R, Persaud A, Mahboob M, Lin S, Spaseska R, Johnson CK, Gordon D, Tissir F, Heiman GA, Tischfield JA, Bocarsly M, Tischfield MA. Nasello C, et al. Among authors: tissir f. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2307156121. doi: 10.1073/pnas.2307156121. Epub 2024 Apr 29. Proc Natl Acad Sci U S A. 2024. PMID: 38683996 Free PMC article.
DIAPH3 predicts survival of patients with MGMT-methylated glioblastoma.
Chehade G, El Hajj N, Aittaleb M, Alkailani MI, Bejaoui Y, Mahdi A, Aldaalis AAH, Verbiest M, Lelotte J, Ruiz-Reig N, Durá I, Raftopoulos C, Tajeddine N, Tissir F. Chehade G, et al. Among authors: tissir f. Front Oncol. 2024 Feb 22;14:1359652. doi: 10.3389/fonc.2024.1359652. eCollection 2024. Front Oncol. 2024. PMID: 38454929 Free PMC article.
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