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Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double-blind, placebo-controlled, phase 2b and 3 trials.
Papi A, Greening NJ, Bhatt SP, Roche N, Celli B, Wedzicha JA, Agustí À, Tal-Singer R, Han MK, Janssens W, Hanania NA, Nair P, Bremner P, Porpodis K, Shibata Y, Korn S, Yang T, Gordon O, Saenz R, Ng J, Cheung DS, Devine J, Grimbaldeston MA, Zhang W, Yang X, Mohan D, Vogelmeier CF, Brightling CE; ALIENTO and ARNASA investigators. Papi A, et al. Lancet. 2026 May 18:S0140-6736(26)00637-9. doi: 10.1016/S0140-6736(26)00637-9. Online ahead of print. Lancet. 2026. PMID: 42150581
On the state of protein function prediction: a report on the fourth CAFA challenge.
Ramola R, De Paolis Kaluza MC, Piovesan D, Peng Y, Joshi P, Mehdiabadi M, Quaglia F, Pancsa R, Chemes LB, Ahmadi M, Ahn H, Altenhoff AM, Asgari E, Aspromonte MC, Atalay V, Babbi G, Baldazzi D, Barot MM, Ben-Hur A, Benso A, Berenberg D, Björne J, Boecker F, Boldi P, Bonello J, Bordin N, Borole P, Ebrahimpour Boroojeny A, Cao R, Di Carlo S, Casadio R, Casiraghi E, Chang JM, Chen C, Chen TM, Cheng J, Chiu S, Dalkıran A, Davidović RS, Dessimoz C, Diao R, Djeddi WE, Dogan T, Flannery ST, Fontana P, Frasca M, Freddolino L, Gemović B, Gillis J, Ginter F, Gligorijevic V, Grossi G, Heinzinger M, Hippe K, Hoehndorf R, Holm L, Hou J, Hover JR, Huang YT, Ispano E, Jabin S, Jain A, Jones DT, Kaewphan S, Kagaya Y, Kanerva J, Kihara D, Kulmanov M, Kumar S, Kurgan L, Lavezzo E, Lees J, Liao WH, Lin H, Linial M, Littmann M, Liu L, Liu T, Liu YW, Makrodimitris S, Manuto L, Martelli PL, Mchardy AC, Merino GA, Milone DH, Mishra S, Mofrad MRK, Moi D, Nakamura T, Narsapuram VK, Nugnes MV, Obayashi T, Ofer D, Paccanaro A, Perovic VR, Petrini A, Politano G, Raimondi D, Rappoport N, Ur Rehman H, Reijnders MJMF, Reinders MJT, Renfrew PD, Rifaioglu AS, Romero AE, Saraswathi A, Savojardo C, Scholes HM, Schoo… See abstract for full author list ➔ Ramola R, et al. Among authors: zhou x. bioRxiv [Preprint]. 2026 May 9:2026.05.06.722942. doi: 10.64898/2026.05.06.722942. bioRxiv. 2026. PMID: 42146430 Free PMC article. Preprint.
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