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Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion.
Zhu C, Dixon KO, Newcomer K, Gu G, Xiao S, Zaghouani S, Schramm MA, Wang C, Zhang H, Goto K, Christian E, Rangachari M, Rosenblatt-Rosen O, Okada H, Mak T, Singer M, Regev A, Kuchroo V. Zhu C, et al. Among authors: singer m. Sci Adv. 2021 Apr 30;7(18):eabd2710. doi: 10.1126/sciadv.abd2710. Print 2021 Apr. Sci Adv. 2021. PMID: 33931442 Free PMC article.
Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment.
Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, Dulberg S, Christian E, Ferreira M, Dixon KO, Fell G, Tooley K, Mangani D, Xia J, Singer M, Bosenberg M, Neuberg D, Rozenblatt-Rosen O, Regev A, Kuchroo VK, Anderson AC. Acharya N, et al. Among authors: singer m. Immunity. 2020 Sep 15;53(3):658-671.e6. doi: 10.1016/j.immuni.2020.08.005. Immunity. 2020. PMID: 32937153 Free PMC article.
Molecular Dissection of CD8+ T-Cell Dysfunction.
Wang C, Singer M, Anderson AC. Wang C, et al. Among authors: singer m. Trends Immunol. 2017 Aug;38(8):567-576. doi: 10.1016/j.it.2017.05.008. Epub 2017 Jun 26. Trends Immunol. 2017. PMID: 28662970 Free PMC article. Review.
Induction and transcriptional regulation of the co-inhibitory gene module in T cells.
Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, Nyman J, Marjanovic ND, Kowalczyk MS, Wang C, Kurtulus S, Law T, Etminan Y, Nevin J, Buckley CD, Burkett PR, Buenrostro JD, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK. Chihara N, et al. Among authors: singer m. Nature. 2018 Jun;558(7710):454-459. doi: 10.1038/s41586-018-0206-z. Epub 2018 Jun 13. Nature. 2018. PMID: 29899446 Free PMC article.
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity.
Schnell A, Huang L, Singer M, Singaraju A, Barilla RM, Regan BML, Bollhagen A, Thakore PI, Dionne D, Delorey TM, Pawlak M, Meyer Zu Horste G, Rozenblatt-Rosen O, Irizarry RA, Regev A, Kuchroo VK. Schnell A, et al. Among authors: singer m. Cell. 2021 Dec 22;184(26):6281-6298.e23. doi: 10.1016/j.cell.2021.11.018. Epub 2021 Dec 6. Cell. 2021. PMID: 34875227 Free PMC article.
Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias.
Raundhal M, Ghosh S, Myers SA, Cuoco MS, Singer M, Carr SA, Waikar SS, Bonventre JV, Ritz J, Stone RM, Steensma DP, Regev A, Glimcher LH. Raundhal M, et al. Among authors: singer m. Nat Immunol. 2021 Apr;22(4):520-529. doi: 10.1038/s41590-021-00895-4. Epub 2021 Mar 22. Nat Immunol. 2021. PMID: 33753942 Free PMC article.
2,631 results