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Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling.
Lasker MV, Gajjar MM, Nair SK. Lasker MV, et al. J Immunol. 2005 Oct 1;175(7):4175-9. doi: 10.4049/jimmunol.175.7.4175. J Immunol. 2005. PMID: 16177054
IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. ...
IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for …
Metal ion-mediated reduction in surface entropy improves diffraction quality of crystals of the IRAK-4 death domain.
Lasker MV, Kuruvilla SM, Gajjar MM, Kapoor A, Nair SK. Lasker MV, et al. J Biomol Tech. 2006 Apr;17(2):114-21. J Biomol Tech. 2006. PMID: 16741238 Free PMC article.
Interleukin-1 receptor-associated kinase-4 (IRAK-4) is an essential component of innate immunity in mice and humans. ...Addition of manganese (II) chloride to the crystallization solution produced significant improvements in diffraction, and the structure has been determin …
Interleukin-1 receptor-associated kinase-4 (IRAK-4) is an essential component of innate immunity in mice and humans. ...Addition of m …