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Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.
Payeli SK, Kollnberger S, Marroquin Belaunzaran O, Thiel M, McHugh K, Giles J, Shaw J, Kleber S, Ridley A, Wong-Baeza I, Keidel S, Kuroki K, Maenaka K, Wadle A, Renner C, Bowness P. Payeli SK, et al. Arthritis Rheum. 2012 Oct;64(10):3139-49. doi: 10.1002/art.34538. Arthritis Rheum. 2012. PMID: 22576154 Free article.
A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.
Owen EP, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, Thomas AD, Harris CL, Giles JL, Hellerud BC, Mollnes TE, Morgan BP, Potter PC, Orren A. Owen EP, et al. Mol Immunol. 2015 Mar;64(1):170-6. doi: 10.1016/j.molimm.2014.11.010. Epub 2014 Dec 19. Mol Immunol. 2015. PMID: 25534848 Free article.