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Generation of a Novel High-Affinity Antibody Binding to PCSK9 Catalytic Domain with Slow Dissociation Rate by CDR-Grafting, Alanine Scanning and Saturated Site-Directed Mutagenesis for Favorably Treating Hypercholesterolemia.
Biomedicines. 2021 Nov 27;9(12):1783. doi: 10.3390/biomedicines9121783.
Biomedicines. 2021.
PMID: 34944600
Free PMC article.
A novel fully human anti-NT-ANGPTL3 antibody from phage display library exhibits potent ApoB, TG, and LDL-C lowering activities in hyperlipidemia mice.
Zhang P, Wang K, Hu T, Xu M, You X, Chen M, Tang X, Hu H, Jiang Y, Zhao W, Tan S.
Zhang P, et al.
FASEB J. 2024 Jan;38(1):e23399. doi: 10.1096/fj.202301564RR.
FASEB J. 2024.
PMID: 38174870
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