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Targeting Cancer Metabolism Plasticity with JX06 Nanoparticles via Inhibiting PDK1 Combined with Metformin for Endometrial Cancer Patients with Diabetes.
Yang X, Cheng Y, Zhou J, Zhang L, Li X, Wang Z, Yin S, Zhai L, Huang T, Wu X, Shen B, Dong Y, Zhao L, Chi Y, Jia Y, Wang J, He Y, Dong X, Xiao H, Wang J. Yang X, et al. Adv Sci (Weinh). 2022 Mar;9(8):e2104472. doi: 10.1002/advs.202104472. Epub 2022 Jan 22. Adv Sci (Weinh). 2022. PMID: 35064767 Free PMC article.
Phosphorylation of IDH1 Facilitates Progestin Resistance in Endometrial Cancer.
Li J, Qin Z, Li Y, Huang B, Xiao Q, Chen P, Luo Y, Zheng W, Zhang T, Zhang Z. Li J, et al. Adv Sci (Weinh). 2024 Apr 6:e2310208. doi: 10.1002/advs.202310208. Online ahead of print. Adv Sci (Weinh). 2024. PMID: 38582508
Pharmacological inhibition of p38 or focal adhesion signaling sensitizes endometrial cancer cells to progestin in vivo. The study reveals p38-dependent pT77-IDH1 as a key mediator of progestin resistance and a promising target for improving the efficacy of progestin therap …
Pharmacological inhibition of p38 or focal adhesion signaling sensitizes endometrial cancer cells to progestin in vivo. The study reveals p3 …