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Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
Patil H, Saha A, Senda E, Cho KI, Haque M, Yu M, Qiu S, Yoon D, Hao Y, Peachey NS, Ferreira PA. Patil H, et al. J Biol Chem. 2014 Oct 24;289(43):29767-89. doi: 10.1074/jbc.M114.586834. Epub 2014 Sep 3. J Biol Chem. 2014. PMID: 25187515 Free PMC article.
MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.
Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG. Sachdeva M, et al. J Clin Invest. 2014 Oct;124(10):4305-19. doi: 10.1172/JCI77116. Epub 2014 Sep 2. J Clin Invest. 2014. PMID: 25180607 Free PMC article.