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Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.
Mol Cell. 2008 Dec 26;32(6):838-48. doi: 10.1016/j.molcel.2008.12.004.
Mol Cell. 2008.
PMID: 19111663
Free PMC article.
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.
Zimmer M, Lamb J, Ebert BL, Lynch M, Neil C, Schmidt E, Golub TR, Iliopoulos O.
Zimmer M, et al.
Cancer Res. 2010 Apr 15;70(8):3071-9. doi: 10.1158/0008-5472.CAN-09-2877. Epub 2010 Mar 30.
Cancer Res. 2010.
PMID: 20354189
Free PMC article.
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