AI044639/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2003	1
2005	1
2006	1
2007	3
2008	5
2009	4
2010	6
2011	7
2012	3
2013	3
2014	1
2016	1
2017	1
2024	0

1

Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.

Pan P, Tonge PJ. Pan P, et al. Curr Top Med Chem. 2012;12(7):672-93. doi: 10.2174/156802612799984535. Curr Top Med Chem. 2012. PMID: 22283812 Free PMC article. Review.

2

Drug-target residence time: critical information for lead optimization.

Lu H, Tonge PJ. Lu H, et al. Curr Opin Chem Biol. 2010 Aug;14(4):467-74. doi: 10.1016/j.cbpa.2010.06.176. Epub 2010 Jul 19. Curr Opin Chem Biol. 2010. PMID: 20663707 Free PMC article. Review.

3

Substrate recognition by β-ketoacyl-ACP synthases.

Borgaro JG, Chang A, Machutta CA, Zhang X, Tonge PJ. Borgaro JG, et al. Biochemistry. 2011 Dec 13;50(49):10678-86. doi: 10.1021/bi201199x. Epub 2011 Nov 17. Biochemistry. 2011. PMID: 22017312 Free PMC article.

4

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

Bommineni GR, Kapilashrami K, Cummings JE, Lu Y, Knudson SE, Gu C, Walker SG, Slayden RA, Tonge PJ. Bommineni GR, et al. J Med Chem. 2016 Jun 9;59(11):5377-90. doi: 10.1021/acs.jmedchem.6b00236. Epub 2016 May 24. J Med Chem. 2016. PMID: 27187871 Free PMC article.

5

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.

Liu N, Cummings JE, England K, Slayden RA, Tonge PJ. Liu N, et al. J Antimicrob Chemother. 2011 Mar;66(3):564-73. doi: 10.1093/jac/dkq509. Epub 2011 Jan 22. J Antimicrob Chemother. 2011. PMID: 21393229 Free PMC article.

6

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

Neckles C, Eltschkner S, Cummings JE, Hirschbeck M, Daryaee F, Bommineni GR, Zhang Z, Spagnuolo L, Yu W, Davoodi S, Slayden RA, Kisker C, Tonge PJ. Neckles C, et al. Biochemistry. 2017 Apr 4;56(13):1865-1878. doi: 10.1021/acs.biochem.6b01048. Epub 2017 Mar 21. Biochemistry. 2017. PMID: 28225601 Free PMC article.

7

Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.

Machutta CA, Bommineni GR, Luckner SR, Kapilashrami K, Ruzsicska B, Simmerling C, Kisker C, Tonge PJ. Machutta CA, et al. J Biol Chem. 2010 Feb 26;285(9):6161-9. doi: 10.1074/jbc.M109.077909. Epub 2009 Dec 16. J Biol Chem. 2010. PMID: 20018879 Free PMC article.

8

Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei.

Lu H, Tonge PJ. Lu H, et al. Biochemistry. 2010 Feb 16;49(6):1281-9. doi: 10.1021/bi902001a. Biochemistry. 2010. PMID: 20055482 Free PMC article.

9

Substrate recognition by the human fatty-acid synthase.

Carlisle-Moore L, Gordon CR, Machutta CA, Miller WT, Tonge PJ. Carlisle-Moore L, et al. J Biol Chem. 2005 Dec 30;280(52):42612-8. doi: 10.1074/jbc.M507082200. Epub 2005 Oct 7. J Biol Chem. 2005. PMID: 16215233 Free PMC article.

10

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.

Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D. Lauinger IL, et al. J Nat Prod. 2013 Jun 28;76(6):1064-70. doi: 10.1021/np400083k. Epub 2013 Jun 19. J Nat Prod. 2013. PMID: 23806111 Free PMC article.

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