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NAADP-binding proteins find their identity.
Marchant JS, Gunaratne GS, Cai X, Slama JT, Patel S. Marchant JS, et al. Trends Biochem Sci. 2022 Mar;47(3):235-249. doi: 10.1016/j.tibs.2021.10.008. Epub 2021 Nov 20. Trends Biochem Sci. 2022. PMID: 34810081 Free PMC article. Review.
Discovery of lipophilic two-pore channel agonists.
Gerndt S, Krogsaeter E, Patel S, Bracher F, Grimm C. Gerndt S, et al. FEBS J. 2020 Dec;287(24):5284-5293. doi: 10.1111/febs.15432. Epub 2020 Jun 14. FEBS J. 2020. PMID: 32478984 Free article. Review.
Thinking through acidic Ca2+ stores.
Patel S, Brailoiu E. Patel S, et al. Sci Signal. 2018 Nov 27;11(558):eaau3342. doi: 10.1126/scisignal.aau3342. Sci Signal. 2018. PMID: 30482848 Review.
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. Gerndt S, et al. Elife. 2020 Mar 16;9:e54712. doi: 10.7554/eLife.54712. Elife. 2020. PMID: 32167471 Free PMC article.
The lysosomotrope GPN mobilises Ca2+ from acidic organelles.
Yuan Y, Kilpatrick BS, Gerndt S, Bracher F, Grimm C, Schapira AH, Patel S. Yuan Y, et al. J Cell Sci. 2021 Mar 11;134(6):jcs256578. doi: 10.1242/jcs.256578. J Cell Sci. 2021. PMID: 33602742 Free PMC article.