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Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model.
Pan Q, Xu X, He W, Wang Y, Xiang Z, Jin X, Tang Q, Zhao T, Ma X. Pan Q, et al. Biol Res. 2023 Apr 1;56(1):16. doi: 10.1186/s40659-023-00418-5. Biol Res. 2023. PMID: 37005678 Free PMC article.
BACKGROUND/AIMS: Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-released exosomes (EPC-EXs) contribute to vascular …
BACKGROUND/AIMS: Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in …
MiR-17-5p Mediates the Effects of ACE2-Enriched Endothelial Progenitor Cell-Derived Exosomes on Ameliorating Cerebral Ischemic Injury in Aged Mice.
Pan Q, Wang Y, Liu J, Jin X, Xiang Z, Li S, Shi Y, Chen Y, Zhong W, Ma X. Pan Q, et al. Mol Neurobiol. 2023 Jun;60(6):3534-3552. doi: 10.1007/s12035-023-03280-4. Epub 2023 Mar 9. Mol Neurobiol. 2023. PMID: 36892728
Here, we aimed to investigate whether ACE2-enriched EPC-EXs (ACE2-EPC-EXs) could attenuate brain ischemic injury by inhibiting cerebral EC damage through their carried miR-17-5p and the underlying molecular mechanisms. ...The results showed that (1) the level of …
Here, we aimed to investigate whether ACE2-enriched EPC-EXs (ACE2-EPC-EXs) could attenuate brain ischemic injury by inhibiting cer …