DA 09045/DA/NIDA NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
1998	1
2000	2
2002	1
2003	1
2004	1
2005	1
2008	1
2009	2
2024	0

1

Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse.

Froimowitz M, Wu KM, Moussa A, Haidar RM, Jurayj J, George C, Gardner EL. Froimowitz M, et al. J Med Chem. 2000 Dec 28;43(26):4981-92. doi: 10.1021/jm000201d. J Med Chem. 2000. PMID: 11150168

2

Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).

Cueva JP, Cai TB, Mascarella SW, Thomas JB, Navarro HA, Carroll FI. Cueva JP, et al. J Med Chem. 2009 Dec 10;52(23):7463-72. doi: 10.1021/jm900756t. J Med Chem. 2009. PMID: 19954245 Free PMC article.

3

Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).

Cai TB, Zou Z, Thomas JB, Brieaddy L, Navarro HA, Carroll FI. Cai TB, et al. J Med Chem. 2008 Mar 27;51(6):1849-60. doi: 10.1021/jm701344b. Epub 2008 Feb 29. J Med Chem. 2008. PMID: 18307295

4

Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist.

Carroll I, Thomas JB, Dykstra LA, Granger AL, Allen RM, Howard JL, Pollard GT, Aceto MD, Harris LS. Carroll I, et al. Eur J Pharmacol. 2004 Oct 6;501(1-3):111-9. doi: 10.1016/j.ejphar.2004.08.028. Eur J Pharmacol. 2004. PMID: 15464069

5

Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.

Thomas JB, Atkinson RN, Vinson NA, Catanzaro JL, Perretta CL, Fix SE, Mascarella SW, Rothman RB, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. J Med Chem. 2003 Jul 3;46(14):3127-37. doi: 10.1021/jm030094y. J Med Chem. 2003. PMID: 12825951

6

Neutral antagonist activity of naltrexone and 6beta-naltrexol in naïve and opioid-dependent C6 cells expressing a mu-opioid receptor.

Divin MF, Bradbury FA, Carroll FI, Traynor JR. Divin MF, et al. Br J Pharmacol. 2009 Apr;156(7):1044-53. doi: 10.1111/j.1476-5381.2008.00035.x. Epub 2009 Feb 13. Br J Pharmacol. 2009. PMID: 19220294 Free PMC article.

7

Conformational preferences of the potent dopamine reuptake blocker BTCP and its analogs and their incorporation into a pharmacophore model.

Froimowitz M, Wu KM, Rodrigo J, George C. Froimowitz M, et al. J Comput Aided Mol Des. 2000 Feb;14(2):135-46. doi: 10.1023/a:1008144707255. J Comput Aided Mol Des. 2000. PMID: 10721502

8

Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.

Thomas JB, Atkinson RN, Namdev N, Rothman RB, Gigstad KM, Fix SE, Mascarella SW, Burgess JP, Vinson NA, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. J Med Chem. 2002 Aug 1;45(16):3524-30. doi: 10.1021/jm020084h. J Med Chem. 2002. PMID: 12139463

9

Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model.

Carroll FI, Harris LS, Aceto MD. Carroll FI, et al. Eur J Pharmacol. 2005 Nov 7;524(1-3):89-94. doi: 10.1016/j.ejphar.2005.09.013. Epub 2005 Oct 19. Eur J Pharmacol. 2005. PMID: 16236279

10

Conformational analysis and a crystal structure of bupropion, an antidepressant with dopamine reuptake blocking activity.

Froimowitz M, George C. Froimowitz M, et al. J Chem Inf Comput Sci. 1998 May-Jun;38(3):506-10. doi: 10.1021/ci980401m. J Chem Inf Comput Sci. 1998. PMID: 9611786

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