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Cross-reactive adaptive immune response to oral commensal bacteria results in an induction of receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent periodontal bone resorption in a mouse model.
Kawai T, Paster BJ, Komatsuzawa H, Ernst CW, Goncalves RB, Sasaki H, Ouhara K, Stashenko PP, Sugai M, Taubman MA. Kawai T, et al. Oral Microbiol Immunol. 2007 Jun;22(3):208-15. doi: 10.1111/j.1399-302X.2007.00348.x. Oral Microbiol Immunol. 2007. PMID: 17488448
Diminished forkhead box P3/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kappaB ligand (RANKL+) T cells in bone resorption lesion of periodontal disease.
Ernst CW, Lee JE, Nakanishi T, Karimbux NY, Rezende TM, Stashenko P, Seki M, Taubman MA, Kawai T. Ernst CW, et al. Clin Exp Immunol. 2007 May;148(2):271-80. doi: 10.1111/j.1365-2249.2006.03318.x. Epub 2007 Mar 9. Clin Exp Immunol. 2007. PMID: 17355249 Free PMC article.