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Lipopolysaccharide-Enhanced Responses against Aryl Hydrocarbon Receptor in FcgRIIb-Deficient Macrophages, a Profound Impact of an Environmental Toxin on a Lupus-Like Mouse Model.
Udompornpitak K, Bhunyakarnjanarat T, Charoensappakit A, Dang CP, Saisorn W, Leelahavanichkul A. Udompornpitak K, et al. Int J Mol Sci. 2021 Apr 18;22(8):4199. doi: 10.3390/ijms22084199. Int J Mol Sci. 2021. PMID: 33919603 Free PMC article.
Additionally, the responses from FcgRIIb(-/-) macrophages were more prominent than wild-type (WT) cells as determined by (i) supernatant cytokines (TNF-alpha, IL-6, and IL-10), (ii) expression of the inflammation associated genes (NF-kappaB, aryl hydrocarbon receptor, iNOS, IL-1b …
Additionally, the responses from FcgRIIb(-/-) macrophages were more prominent than wild-type (WT) cells as determined by (i) supernatant cyt …
Prominent Indomethacin-Induced Enteropathy in Fcgriib Defi-cient lupus Mice: An Impact of Macrophage Responses and Immune Deposition in Gut.
Bhunyakarnjanarat T, Udompornpitak K, Saisorn W, Chantraprapawat B, Visitchanakun P, Dang CP, Issara-Amphorn J, Leelahavanichkul A. Bhunyakarnjanarat T, et al. Int J Mol Sci. 2021 Jan 29;22(3):1377. doi: 10.3390/ijms22031377. Int J Mol Sci. 2021. PMID: 33573095 Free PMC article.
Due to a lack of inhibitory-FcgRIIb expression, mitochondrial function, and cytokine production of FcgRIIb-/- macrophages were more prominent than WT cells. Hence, lupus disease-activation from NSAIDs-enteropathy-induced gut leakage is possible....
Due to a lack of inhibitory-FcgRIIb expression, mitochondrial function, and cytokine production of FcgRIIb-/- macrophages were more prominen …