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The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum.
J Biol Chem. 2003 May 9;278(19):17344-9. doi: 10.1074/jbc.M212710200. Epub 2003 Mar 6.
J Biol Chem. 2003.
PMID: 12624096
Free article.
The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling.
Lievens PM, Mutinelli C, Baynes D, Liboi E.
Lievens PM, et al.
J Biol Chem. 2004 Oct 8;279(41):43254-60. doi: 10.1074/jbc.M405247200. Epub 2004 Aug 2.
J Biol Chem. 2004.
PMID: 15292251
Free article.
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