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The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver.
Arch Toxicol. 2019 Jul;93(7):1917-1926. doi: 10.1007/s00204-019-02488-5. Epub 2019 May 20.
Arch Toxicol. 2019.
PMID: 31111189
Free PMC article.
Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events.
Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T, Homey B, Meller S.
Hawerkamp HC, et al.
Allergy. 2019 Dec;74(12):2437-2448. doi: 10.1111/all.13972. Epub 2019 Sep 3.
Allergy. 2019.
PMID: 31269229
Free PMC article.
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