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The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase.
Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. Alhammad YMO, et al. J Virol. 2021 Jan 13;95(3):e01969-20. doi: 10.1128/JVI.01969-20. Print 2021 Jan 13. J Virol. 2021. PMID: 33158944 Free PMC article.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice.
Alhammad YM, Parthasarathy S, Ghimire R, Kerr CM, O'Connor JJ, Pfannenstiel JJ, Chanda D, Miller CA, Baumlin N, Salathe M, Unckless RL, Zuñiga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120. Epub 2023 Aug 22. Proc Natl Acad Sci U S A. 2023. PMID: 37607224 Free PMC article.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
Alhammad YM, Parthasarathy S, Ghimire R, O'Connor JJ, Kerr CM, Pfannenstiel JJ, Chanda D, Miller CA, Unckless RL, Zuniga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.06.535927. doi: 10.1101/2023.04.06.535927. bioRxiv. 2023. PMID: 37066301 Free PMC article. Updated. Preprint.
Mutation of highly conserved residues in loop 2 of the coronavirus macrodomain demonstrates that enhanced ADP-ribose binding is detrimental to infection.
Kerr CM, Pfannenstiel JJ, Alhammad YM, Roy A, O'Connor JJ, Ghimire R, Khattabi R, Shrestha R, McDonald PR, Gao P, Johnson DK, More S, Channappanavar R, Fehr AR. Kerr CM, et al. bioRxiv [Preprint]. 2024 Jan 4:2024.01.03.574082. doi: 10.1101/2024.01.03.574082. bioRxiv. 2024. PMID: 38260573 Free PMC article. Preprint.
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