A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells.
Wilde EC, Chapman KE, Stannard LM, Seager AL, Brüsehafer K, Shah UK, Tonkin JA, Brown MR, Verma JR, Doherty AT, Johnson GE, Doak SH, Jenkins GJS.
Wilde EC, et al.
Arch Toxicol. 2018 Feb;92(2):935-951. doi: 10.1007/s00204-017-2102-y. Epub 2017 Nov 6.
Arch Toxicol. 2018.
PMID: 29110037
Free PMC article.
The richer datasets generated proved that the holistic evaluation of integrated phenotypic alterations is valuable for effective in vitro risk assessment, while also supporting animal test replacement. Crucially, the study offers valuable insights into the mechanisms of hu …
The richer datasets generated proved that the holistic evaluation of integrated phenotypic alterations is valuable for effective in vitro ri …