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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
Spiro[3.3]heptane as a Saturated Benzene Bioisostere.
Prysiazhniuk K, Datsenko OP, Polishchuk O, Shulha S, Shablykin O, Nikandrova Y, Horbatok K, Bodenchuk I, Borysko P, Shepilov D, Pishel I, Kubyshkin V, Mykhailiuk PK. Prysiazhniuk K, et al. Among authors: polishchuk o. Angew Chem Int Ed Engl. 2024 Feb 26;63(9):e202316557. doi: 10.1002/anie.202316557. Epub 2024 Jan 22. Angew Chem Int Ed Engl. 2024. PMID: 38251921
Borylated cyclobutanes via thermal [2 + 2]-cycloaddition.
Prysiazhniuk K, Polishchuk O, Shulha S, Gudzikevych K, Datsenko OP, Kubyshkin V, Mykhailiuk PK. Prysiazhniuk K, et al. Among authors: polishchuk o. Chem Sci. 2024 Jan 25;15(9):3249-3254. doi: 10.1039/d3sc06600b. eCollection 2024 Feb 28. Chem Sci. 2024. PMID: 38425521 Free PMC article.