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Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Hutchinson MR, Coats BD, Lewis SS, Zhang Y, Sprunger DB, Rezvani N, Baker EM, Jekich BM, Wieseler JL, Somogyi AA, Martin D, Poole S, Judd CM, Maier SF, Watkins LR. Hutchinson MR, et al. Brain Behav Immun. 2008 Nov;22(8):1178-89. doi: 10.1016/j.bbi.2008.05.004. Epub 2008 Jul 2. Brain Behav Immun. 2008. PMID: 18599265 Free PMC article.
Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.
Hutchinson MR, Northcutt AL, Chao LW, Kearney JJ, Zhang Y, Berkelhammer DL, Loram LC, Rozeske RR, Bland ST, Maier SF, Gleeson TT, Watkins LR. Hutchinson MR, et al. Brain Behav Immun. 2008 Nov;22(8):1248-56. doi: 10.1016/j.bbi.2008.07.008. Epub 2008 Jul 31. Brain Behav Immun. 2008. PMID: 18706994 Free PMC article.